Regulation of protein tyrosine phosphatase oxidation in cell adhesion and migration

Antioxidants and Redox Signaling

Volumn 20, Issue 13, 2014, Pages 1994-2010

  Frijhoff, Jeroen ^a   Dagnell, Markus ^a   Godfrey, Rinesh ^b   Östman, Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; HYDROGEN PEROXIDE; HYDROGEN SULFIDE; LIPID PEROXIDE; PROTEIN TYROSINE PHOSPHATASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

CARDIOVASCULAR DISEASE; CATALYSIS; CELL ADHESION; CELL MIGRATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; FIBROBLAST; HUMAN; NEOPLASM; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CELL MOTION; METABOLISM; OXIDATION REDUCTION REACTION;

ANIMALS; CELL ADHESION; CELL MOVEMENT; HUMANS; OXIDATION-REDUCTION; PROTEIN TYROSINE PHOSPHATASES;

EID: 84898416421     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5643     Document Type: Review

References (164)

1. Abdelsaid MA, Matragoon S, and El-Remessy AB. Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells. Antioxid Redox Signal 19: 2199-2212, 2013
2. Abdelsaid MA and El-Remessy AB. S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration. J Cell Sci 125: 4751-4760, 2012
3. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, and Mustelin T. Protein tyrosine phosphatases in the human genome. Cell 117: 699-711, 2004
4. Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, Jansen PG, Andersen HS, Tonks NK, and Moller NP. Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol 21: 7117-7136, 2001
5. Arner ES and Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem 267: 6102-6109, 2000
6. Arora D, Stopp S, Bohmer SA, Schons J, Godfrey R, Masson K, Razumovskaya E, Ronnstrand L, Tanzer S, Bauer R, Bohmer FD, and Muller JP. Protein-Tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem 286: 10918-10929, 2011
7. Bae YS, Sung JY, Kim OS, Kim YJ, Hur KC, Kazlauskas A, and Rhee SG. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem 275: 10527-10531, 2000
8. Barrett DM, Black SM, Todor H, Schmidt-Ullrich RK, Dawson KS, and Mikkelsen RB. Inhibition of proteintyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J Biol Chem 280: 14453-14461, 2005
9. Barrett WC, DeGnore JP, Konig S, Fales HM, Keng YF, Zhang ZY, Yim MB, and Chock PB. Regulation of PTP1B via glutathionylation of the active site cysteine 215. Biochemistry 38: 6699-6705, 1999
10. Barrett WC, DeGnore JP, Keng YF, Zhang ZY, Yim MB, and Chock PB. Roles of superoxide radical anion in signal transduction mediated by reversible regulation of proteintyrosine phosphatase 1B. J Biol Chem 274: 34543-34546, 1999
11. Baumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, and Rosenkranz S. Phosphatidylinositol 3-kinasedependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem 283: 7864-7876, 2008
12. Beillerot A, Battaglia E, Aline B, and Bagrel D. Protection of CDC25 phosphatases against oxidative stress in breast cancer cells: Evaluation of the implication of the thioredoxin system. Free Radic Res 46: 674-689, 2012
13. Belousov VV, Fradkov AF, Lukyanov KA, Staroverov DB, Shakhbazov KS, Terskikh AV, and Lukyanov S. Genetically encoded fluorescent indicator for intracellular hydrogen peroxide. Nat Methods 3: 281-286, 2006
14. Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, and Giorgio M. p66Shcgenerated oxidative signal promotes fat accumulation. J Biol Chem 283: 34283-34293, 2008
15. Bhattacharya R, Kwon J, Wang E, Mukherjee P, and Mukhopadhyay D. Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration. J Mol Signal 3: 8, 2008
16. Bhattacharya S, Labutti JN, Seiner DR, and Gates KS. Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides. Bioorg Med Chem Lett 18: 5856-5859, 2008
17. Blanchetot C, Tertoolen LG, and den Hertog J. Regulation of receptor protein-Tyrosine phosphatase alpha by oxidative stress. EMBO J 21: 493-503, 2002
18. Blaskovich MA. Drug discovery and protein tyrosine phosphatases. Curr Med Chem 16: 2095-2176, 2009
19. Bohmer F, Szedlacsek S, Tabernero L, Ostman A, and den Hertog J. Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis. FEBS J 280: 413-431, 2013
20. Bohmer SA, Weibrecht I, Soderberg O, and Bohmer FD. Association of the protein-Tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay. PLoS One 8: E62871, 2013
21. Bonham CA and Vacratsis PO. Redox regulation of the human dual specificity phosphatase YVH1 through disulfide bond formation. J Biol Chem 284: 22853-22864, 2009
22. Cai J, Jiang WG, Ahmed A, and Boulton M. Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS. Microvasc Res 71: 20-31, 2006
23. Cao C, Leng Y, Huang W, Liu X, and Kufe D. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem 278: 39609-39614, 2003
24. Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, and Neumann CA. Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J 28: 1505-1517, 2009
25. Caselli A, Marzocchini R, Camici G, Manao G, Moneti G, Pieraccini G, and Ramponi G. The inactivation mechanism of low molecular weight phosphotyrosine-protein phosphatase by H2O2. J Biol Chem 273: 32554-32560, 1998
26. Chabot C, Spring K, Gratton JP, Elchebly M, and Royal I. New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol Cell Biol 29: 241-253, 2009
27. Chen CY, Willard D, and Rudolph J. Redox regulation of SH2-domain-containing protein tyrosine phosphatases by two backdoor cysteines. Biochemistry 48: 1399-1409, 2009
28. Chen K, Kirber MT, Xiao H, Yang Y, and Keaney JF, Jr. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181: 1129-1139, 2008
29. Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, and Meng TC. Cysteine S-nitrosylation protects protein-Tyrosine phosphatase 1B against oxidationinduced permanent inactivation. J Biol Chem 283: 35265-35272, 2008
30. Chetram MA, Bethea DA, Odero-Marah VA, Don-Salu-Hewage AS, Jones KJ, and Hinton CV. ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells. Mol Cell Biochem 376: 63-71, 2013
31. Chetram MA, Don-Salu-Hewage AS, and Hinton CV. ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells. Biochem Biophys Res Commun 410: 195-200, 2011
32. Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, Symons M, Borrello S, Galeotti T, and Ramponi G. Reactive oxygen species as essential mediators of cell adhesion: The oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol 161: 933-944, 2003
33. Chiarugi P, Fiaschi T, Taddei ML, Talini D, Giannoni E, Raugei G, and Ramponi G. Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation. J Biol Chem 276: 33478-33487, 2001
34. Cho CS, Lee S, Lee GT, Woo HA, Choi EJ, and Rhee SG. Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells. Antioxid Redox Signal 12: 1235-1246, 2010
35. Cho KJ, Seo JM, and Kim JH. Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species. Mol Cells 32: 1-5, 2011
36. Choi MH, Lee IK, Kim GW, Kim BU, Han YH, Yu DY, Park HS, Kim KY, Lee JS, Choi C, Bae YS, Lee BI, Rhee SG, and Kang SW. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435: 347-353, 2005
37. Conrad M, Sandin A, Forster H, Seiler A, Frijhoff J, Dagnell M, Bornkamm GW, Radmark O, Hooft van Huijsduijnen R, Aspenstrom P, Bohmer F, and Ostman A. 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc Natl Acad Sci U S A 107: 15774-15779, 2010
38. Covey TM, Edes K, and Fitzpatrick FA. Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. Oncogene 26: 5784-5792, 2007
39. Dagnell M, Frijhoff J, Pader I, Augsten M, Boivin B, Xu J, Mandal PK, Tonks NK, Hellberg C, Conrad M, Arner ES, and Ostman A. Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-beta receptor tyrosine kinase signaling. Proc Natl Acad Sci U S A 110: 13398-13403, 2013
40. de Carvalho DD, Sadok A, Bourgarel-Rey V, Gattacceca F, Penel C, Lehmann M, and Kovacic H. Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells. Int J Cancer 122: 1757-1764, 2008
41. den Hertog J, Ostman A, and Bohmer FD. Protein tyrosine phosphatases: Regulatory mechanisms. FEBS J 275: 831-847, 2008
42. Denu JM and Tanner KG. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37: 5633-5642, 1998
43. Denu JM, Lohse DL, Vijayalakshmi J, Saper MA, and Dixon JE. Visualization of intermediate and transition-state structures in protein-Tyrosine phosphatase catalysis. Proc Natl Acad Sci U S A 93: 2493-2498, 1996
44. Fauman EB, Cogswell JP, Lovejoy B, RocqueWJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, and Saper MA. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell 93: 617-625, 1998
45. Frey RS, Ushio-Fukai M, and Malik AB. NADPH oxidasedependent signaling in endothelial cells: Role in physiology and pathophysiology. Antioxid Redox Signal 11: 791-810, 2009
46. Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia G, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci F, and Pelicci PG. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122: 221-233, 2005
47. Godfrey R, Arora D, Bauer R, Stopp S, Muller JP, Heinrich T, Bohmer SA, Dagnell M, Schnetzke U, Scholl S, Ostman A, and Bohmer FD. Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-Tyrosine phosphatase DEP-1/PTPRJ. Blood 119: 4499-4511, 2012
48. Goetze S, Eilers F, Bungenstock A, Kintscher U, Stawowy P, Blaschke F, Graf K, Law RE, Fleck E, and Grafe M. PPAR activators inhibit endothelial cell migration by targeting Akt. Biochem Biophys Res Commun 293: 1431-1437, 2002
49. Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, Orsenigo F, Cattelino A, Kemler R, Daniel TO, and Dejana E. Contact inhibition of VEGFinduced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol 161: 793-804, 2003
50. Greiner R, Palinkas Z, Basell K, Becher D, Antelmann H, Nagy P, and Dick TP. Polysulfides link H2S to protein thiol oxidation. Antioxid Redox Signal 19: 1749-1765, 2013
51. Groen A, Lemeer S, van der Wijk T, Overvoorde J, Heck AJ, Ostman A, Barford D, Slijper M, and den Hertog J. Differential oxidation of protein-Tyrosine phosphatases. J Biol Chem 280: 10298-10304, 2005
52. Halliwell B. Oxidative stress and cancer: Have we moved forward?. Biochem J 401: 1-11, 2007
53. Hao Q, Samten B, Ji HL, Zhao ZJ, and Tang H. Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells. Am J Physiol Cell Physiol 303: C548-C553, 2012
54. Haque A, Andersen JN, Salmeen A, Barford D, and Tonks NK. Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell 147: 185-198, 2011
55. Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Young Koh G, Dejana E, Belting HG, Affolter M, Thurston G, Holmgren L, Vestweber D, and Claesson-Welsh L. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun 4: 1672, 2013
56. Hendriks WJ, Elson A, Harroch S, and Stoker AW. Protein tyrosine phosphatases: Functional inferences from mouse models and human diseases. FEBS J 275: 816-830, 2008
57. Hower AE, Beltran PJ, and Bixby JL. Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC. J Neurochem 110: 1635-1647, 2009
58. Huang L, Sankar S, Lin C, Kontos CD, Schroff AD, Cha EH, Feng SM, Li SF, Yu Z, Van Etten RL, Blanar MA, and Peters KG. HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity. J Biol Chem 274: 38183-38188, 1999
59. Huveneers S and Danen EH. Adhesion signaling - crosstalk between integrins, Src and Rho. J Cell Sci 122: 1059-1069, 2009
60. Ishii T, Funato Y, and Miki H. Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL). J Biol Chem 288: 7263-7270, 2013
61. Jeon TJ, Chien PN, Chun HJ, and Ryu SE. Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form. Mol Cells 36: 55-61, 2013
62. Jia Z, Barford D, Flint AJ, and Tonks NK. Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science 268: 1754-1758, 1995
63. Kamata H, Honda S, Maeda S, Chang L, Hirata H, and Karin M. Reactive oxygen species promote TNFalphainduced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-661, 2005
64. Kanda M, Ihara Y, Murata H, Urata Y, Kono T, Yodoi J, Seto S, Yano K, and Kondo T. Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-Tyrosine phosphatase. J Biol Chem 281: 28518-28528, 2006
65. Kappert K, Sparwel J, Sandin A, Seiler A, Siebolts U, Leppanen O, Rosenkranz S, and Ostman A. Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis. Arterioscler Thromb Vasc Biol 26: 2644-2651, 2006
66. Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Ostman A, Moran MF, and Neel BG. Global proteomic assessment of the classical protein-Tyrosine phosphatome and ''redoxome''. Cell 146: 826-840, 2011
67. Karisch R and Neel BG. Methods to monitor classical protein-Tyrosine phosphatase oxidation. FEBS J 280: 459-475, 2013
68. Kazlauskas A, Feng GS, Pawson T, and Valius M. The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci U S A 90: 6939-6943, 1993
69. Kim HS, Ullevig SL, Zamora D, Lee CF, and Asmis R. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A 109: E2803-E2812, 2012
70. Kim JH, Chu SC, Gramlich JL, Pride YB, Babendreier E, Chauhan D, Salgia R, Podar K, Griffin JD, and Sattler M. Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood 105: 1717-1723, 2005
71. Kimura K, Takada M, Ishii T, Tsuji-Naito K, and Akagawa M. Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling. Free Radic Biol Med 53: 1239-1251, 2012
72. Krishnan N, Fu C, Pappin DJ, and Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal 4: Ra86, 2011
73. Kuban-Jankowska A, Tuszynski JA, Winter P, Gorska M, Knap N, and Wozniak M. Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. PLoS One 7: E52495, 2012
74. Kwon J, Qu CK, Maeng JS, Falahati R, Lee C, and Williams MS. Receptor-stimulated oxidation of SHP-2 promotes Tcell adhesion through SLP-76-ADAP. EMBO J 24: 2331-2341, 2005
75. Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, Stadtman ER, and Rhee SG. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A 101: 16419-16424, 2004
76. LaButti JN, Chowdhury G, Reilly TJ, and Gates KS. Redox regulation of protein tyrosine phosphatase 1B by peroxymonophosphate (= O3POOH). J Am Chem Soc 129: 5320-5321, 2007
77. Lane AE, Tan JT, Hawkins CL, Heather AK, and Davies MJ. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-Activated protein kinase (MAPK) pathway in macrophages. Biochem J 430: 161-169, 2010
78. Lee SR, Yang KS, Kwon J, Lee C, Jeong W, and Rhee SG. Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 277: 20336-20342, 2002
79. Lee SR, Kwon KS, Kim SR, and Rhee SG. Reversible inactivation of protein-Tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 273: 15366-15372, 1998
80. Leoni G, Alam A, Neumann PA, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Neish AS, and Nusrat A. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123: 443-454, 2013
81. Li S, Wang H, Xian M, and Whorton AR. Identification of protein nitrosothiols using phosphine-mediated selective reduction. Nitric Oxide 26: 20-26, 2012
82. Li S and Whorton AR. Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols. Arch Biochem Biophys 410: 269-279, 2003
83. Lillig CH, Berndt C, and Holmgren A. Glutaredoxin systems. Biochim Biophys Acta 1780: 1304-1317, 2008
84. Lillig CH and Holmgren A. Thioredoxin and related molecules - from biology to health and disease. Antioxid Redox Signal 9: 25-47, 2007
85. Lin VS and Chang CJ. Fluorescent probes for sensing and imaging biological hydrogen sulfide. Curr Opin Chem Biol 16: 595-601, 2012
86. Lippert AR, Van de Bittner GC, and Chang CJ. Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems. Acc Chem Res 44: 793-804, 2011
87. Liu JC, Chen CH, Chen JJ, and Cheng TH. Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor. Mol Pharmacol 76: 1186-1195, 2009
88. Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM, Stepto N, Wu B, Mitchell CA, Tonks NK, Watt MJ, Febbraio MA, Crack PJ, Andrikopoulos S, and Tiganis T. Reactive oxygen species enhance insulin sensitivity. Cell Metab 10: 260-272, 2009
89. Lohse DL, Denu JM, Santoro N, and Dixon JE. Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-Tyrosinephosphatase PTP1. Biochemistry 36: 4568-4575, 1997
90. Lou YW, Chen YY, Hsu SF, Chen RK, Lee CL, Khoo KH, Tonks NK, and Meng TC. Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells. FEBS J 275: 69-88, 2008
91. Lu J and Holmgren A. The thioredoxin antioxidant system. Free Radic Biol Med 2013 [Epub ahead of print]; DOI: 10.1016/j.freeradbiomed.2013.07.036
92. Mahadev K, Zilbering A, Zhu L, and Goldstein BJ. Insulinstimulated hydrogen peroxide reversibly inhibits proteintyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem 276: 21938-21942, 2001
93. Malinouski M, Zhou Y, Belousov VV, Hatfield DL, and Gladyshev VN. Hydrogen peroxide probes directed to different cellular compartments. PLoS One 6: E14564, 2011
94. Markvicheva KN, Bilan DS, Mishina NM, Gorokhovatsky AY, Vinokurov LM, Lukyanov S, and Belousov VV. A genetically encoded sensor for H2O2 with expanded dynamic range. Bioorg Med Chem 19: 1079-1084, 2011
95. Markvicheva KN, Bogdanova EA, Staroverov DB, Lukyanov S, and Belousov VV. Imaging of intracellular hydrogen peroxide production with HyPer upon stimulation of HeLa cells with epidermal growth factor. Methods Mol Biol 476: 76-83, 2009
96. Mattila E, Auvinen K, Salmi M, and Ivaska J. The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling. J Cell Sci 121: 3570-3580, 2008
97. Meier P, Hemingway H, Lansky AJ, Knapp G, Pitt B, and Seiler C. The impact of the coronary collateral circulation on mortality: A meta-Analysis. Eur Heart J 33: 614-621, 2012
98. Mellberg S, Dimberg A, Bahram F, Hayashi M, Rennel E, Ameur A, Westholm JO, Larsson E, Lindahl P, Cross MJ, and Claesson-Welsh L. Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J 23: 1490-1502, 2009
99. Meng FG and Zhang ZY. Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical. Biochim Biophys Acta 1834: 464-469, 2013
100. Meng TC, Fukada T, and Tonks NK. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9: 387-399, 2002
101. Meng TC, Buckley DA, Galic S, Tiganis T, and Tonks NK. Regulation of insulin signaling through reversible oxidation of the protein-Tyrosine phosphatases TC45 and PTP1B. J Biol Chem 279: 37716-37725, 2004
102. Miller EW and Chang CJ. Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling. Curr Opin Chem Biol 11: 620-625, 2007
103. Mishina NM, Tyurin-Kuzmin PA, Markvicheva KN, Vorotnikov AV, Tkachuk VA, Laketa V, Schultz C, Lukyanov S, and Belousov VV. Does cellular hydrogen peroxide diffuse or act locally?. Antioxid Redox Signal 14: 1-7, 2011
104. Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nystrom T, Belousov V, Schumacker PT, and Winterbourn CC. Unraveling the biological roles of reactive oxygen species. Cell Metab 13: 361-366, 2011
105. Nakamura Y, Patrushev N, Inomata H, Mehta D, Urao N, Kim HW, Razvi M, Kini V, Mahadev K, Goldstein BJ, McKinney R, Fukai T, and Ushio-Fukai M. Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells. Circ Res 102: 1182-1191, 2008
106. Nardozza AP, D'Orazio M, Trapannone R, Corallino S, Filomeni G, Tartaglia M, Battistoni A, Cesareni G, and Castagnoli L. Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization. Mol Cell Biol 32: 1998-2009, 2012
107. Naughton R, Quiney C, Turner SD, and Cotter TG. Bcr-Ablmediated redox regulation of the PI3K/AKT pathway. Leukemia 23: 1432-1440, 2009
108. Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, McKinney R, Poole LB, Fukai T, and Ushio-Fukai M. Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice. PLoS One 5: E10189, 2010
109. Ostman A, Frijhoff J, Sandin A, and Bohmer FD. Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem 150: 345-356, 2011
110. Ostman A, Hellberg C, and Bohmer FD. Protein-Tyrosine phosphatases and cancer. Nat Rev Cancer 6: 307-320, 2006
111. Othman A, Ahmad S, Megyerdi S, Mussell R, Choksi K, Maddipati KR, Elmarakby A, Rizk N, and Al-Shabrawey M. 12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: Contribution of NADPH oxidase. PLoS One 8: E57254, 2013
112. Pannifer AD, Flint AJ, Tonks NK, and Barford D. Visualization of the cysteinyl-phosphate intermediate of a proteintyrosine phosphatase by x-ray crystallography. J Biol Chem 273: 10454-10462, 1998
113. Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, and Huang P. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redoxmediated mechanism. J Cell Biol 175: 913-923, 2006
114. Persson C, Sjoblom T, Groen A, Kappert K, Engstrom U, Hellman U, Heldin CH, den Hertog J, and Ostman A. Preferential oxidation of the second phosphatase domain of receptor-like PTP-Alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci U S A 101: 1886-1891, 2004
115. Peters GH, Frimurer TM, and Olsen OH. Electrostatic evaluation of the signature motif (H/V)CX5R(S/T) in proteintyrosine phosphatases. Biochemistry 37: 5383-5393, 1998
116. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, and Rizzuto R. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science 315: 659-663, 2007
117. Pipp F, Heil M, Issbrucker K, Ziegelhoeffer T, Martin S, van den Heuvel J, Weich H, Fernandez B, Golomb G, Carmeliet P, Schaper W, and Clauss M. VEGFR-1-selective VEGF homologue PlGF is arteriogenic: Evidence for a monocytemediated mechanism. Circ Res 92: 378-385, 2003
118. Pregel MJ and Storer AC. Active site titration of the tyrosine phosphatases SHP-1 and PTP1B using aromatic disulfides. Reaction with the essential cysteine residue in the active site. J Biol Chem 272: 23552-23558, 1997
119. Reynolds RA, Yem AW, Wolfe CL, Deibel MR, Jr., Chidester CG, and Watenpaugh KD. Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle. J Mol Biol 293: 559-568, 1999
120. Rhee SG, Woo HA, Kil IS, and Bae SH. Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J Biol Chem 287: 4403-4410, 2012
121. Rhee SG and Cho CS. Blot-based detection of dehydroalaninecontaining glutathione peroxidase with the use of biotinconjugated cysteamine. Methods Enzymol 474: 23-34, 2010
122. Ross SH, Lindsay Y, Safrany ST, Lorenzo O, Villa F, Toth R, Clague MJ, Downes CP, and Leslie NR. Differential redox regulation within the PTP superfamily. Cell Signal 19: 1521-1530, 2007
123. Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK, and Barford D. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-Amide intermediate. Nature 423: 769-773, 2003
124. Samet JM and Tal TL. Toxicological disruption of signaling homeostasis: Tyrosine phosphatases as targets. Annu Rev Pharmacol Toxicol 50: 215-235, 2010
125. Sandin A, Dagnell M, Gonon A, Pernow J, Stangl V, Aspenstrom P, Kappert K, and Ostman A. Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases. Cell Signal 23: 820-826, 2011
126. Sattler M, Verma S, Shrikhande G, Byrne CH, Pride YB, Winkler T, Greenfield EA, Salgia R, and Griffin JD. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem 275: 24273-24278, 2000
127. Savitsky PA and Finkel T. Redox regulation of Cdc25C. J Biol Chem 277: 20535-20540, 2002
128. Schnabel R and Blankenberg S. Oxidative stress in cardiovascular disease: Successful translation from bench to bedside?. Circulation 116: 1338-1340, 2007
129. Seth D and Rudolph J. Redox regulation of MAP kinase phosphatase 3. Biochemistry 45: 8476-8487, 2006
130. Sharma P, Chakraborty R, Wang L, Min B, Tremblay ML, Kawahara T, Lambeth JD, and Haque SJ. Redox regulation of interleukin-4 signaling. Immunity 29: 551-564, 2008
131. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, and Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A 110: 3137-3142, 2013
132. Shiose A and Sumimoto H. Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase. J Biol Chem 275: 13793-13801, 2000
133. Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, Abecasis M, Nowill AE, Leslie NR, Cardoso AA, and Barata JT. PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest 118: 3762-3774, 2008
134. Sohn J and Rudolph J. Catalytic and chemical competence of regulation of cdc25 phosphatase by oxidation/reduction. Biochemistry 42: 10060-10070, 2003
135. Stone JR and Yang S. Hydrogen peroxide: A signaling messenger. Antioxid Redox Signal 8: 243-270, 2006
136. Stuckey JA, Schubert HL, Fauman EB, Zhang ZY, Dixon JE, and Saper MA. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5A and the complex with tungstate. Nature 370: 571-575, 1994
137. Sullivan SG, Chiu DT, Errasfa M, Wang JM, Qi JS, and Stern A. Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells. Free Radic Biol Med 16: 399-403, 1994
138. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, and Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296-299, 1995
139. Swanson PA, 2nd, Kumar A, Samarin S, Vijay-Kumar M, Kundu K, Murthy N, Hansen J, Nusrat A, and Neish AS. Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. Proc Natl Acad Sci U S A 108: 8803-8808, 2011
140. Tabet F, Schiffrin EL, Callera GE, He Y, Yao G, Ostman A, Kappert K, Tonks NK, and Touyz RM. Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR. Circ Res 103: 149-158, 2008
141. Taddei ML, Parri M, Mello T, Catalano A, Levine AD, Raugei G, Ramponi G, and Chiarugi P. Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species. Antioxid Redox Signal 9: 469-481, 2007
142. Takakura K, Beckman JS, MacMillan-Crow LA, and Crow JP. Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite. Arch Biochem Biophys 369: 197-207, 1999
143. Tchaikovski V, Olieslagers S, Bohmer FD, and Waltenberger J. Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes. Circulation 120: 150-159, 2009
144. Tiganis T and Bennett AM. Protein tyrosine phosphatase function: The substrate perspective. Biochem J 402: 1-15, 2007
145. Tiganis T. Reactive oxygen species and insulin resistance: The good, the bad and the ugly. Trends Pharmacol Sci 32: 82-89, 2011
146. Tonks NK. Protein tyrosine phosphatases: From genes, to function, to disease. Nat Rev Mol Cell Biol 7: 833-846, 2006
147. Tonks NK. Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction. FEBS J 280: 346-378, 2013
148. Trinei M, Migliaccio E, Bernardi P, Paolucci F, Pelicci P, and Giorgio M. p66Shc, Mitochondria, and the generation of reactive oxygen species. Methods Enzymol 528: 99-110, 2013
149. Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orru V, Bottini N, and Chen XS. Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: Insights into redox regulation. Biochemistry 48: 4838-4845, 2009
150. Valius M and Kazlauskas A. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73: 321-334, 1993
151. Waltenberger J, Lange J, and Kranz A. Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals. Circulation 102: 185-190, 2000
152. van der Wijk T, Blanchetot C, Overvoorde J, and den Hertog J. Redox-regulated rotational coupling of receptor protein-Tyrosine phosphatase alpha dimers. J Biol Chem 278: 13968-13974, 2003
153. van Montfort RL, Congreve M, Tisi D, Carr R, and Jhoti H. Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature 423: 773-777, 2003
154. Wan X, Dennis AT, Obejero-Paz C, Overholt JL, Heredia-Moya J, Kirk KL, and Ficker E. Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome. J Biol Chem 286: 2843-2852, 2011
155. Wang Q, Dube D, Friesen RW, LeRiche TG, Bateman KP, Trimble L, Sanghara J, Pollex R, Ramachandran C, Gresser MJ, and Huang Z. Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones. Biochemistry 43: 4294-4303, 2004
156. Weibrecht I, Bohmer SA, Dagnell M, Kappert K, Ostman A, and Bohmer FD. Oxidation sensitivity of the catalytic cysteine of the protein-Tyrosine phosphatases SHP-1 and SHP-2. Free Radic Biol Med 43: 100-110, 2007
157. Winterbourn CC and Hampton MB. Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 45: 549-561, 2008
158. Winterbourn CC. Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol 4: 278-286, 2008
159. Woo HA, Yim SH, Shin DH, Kang D, Yu DY, and Rhee SG. Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell 140: 517-528, 2010
160. Wu RF, Xu YC, Ma Z, Nwariaku FE, Sarosi GA, Jr., and Terada LS. Subcellular targeting of oxidants during endothelial cell migration. J Cell Biol 171: 893-904, 2005
161. Yang J, Groen A, Lemeer S, Jans A, Slijper M, Roe SM, den Hertog J, and Barford D. Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry 46: 709-719, 2007
162. Yu CX, Li S, and Whorton AR. Redox regulation of PTEN by S-nitrosothiols. Mol Pharmacol 68: 847-854, 2005
163. Zhang ZY and Dixon JE. Active site labeling of the Yersinia protein tyrosine phosphatase: The determination of the pKa of the active site cysteine and the function of the conserved histidine 402. Biochemistry 32: 9340-9345, 1993
164. Zhou H, Singh H, Parsons ZD, Lewis SM, Bhattacharya S, Seiner DR, LaButti JN, Reilly TJ, Tanner JJ, and Gates KS. The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases. J Am Chem Soc 133: 15803-15805, 2011.