Redox regulation of SH2-domain-containing protein tyrosine phosphatases by two backdoor cysteines

Biochemistry

Volumn 48, Issue 6, 2009, Pages 1399-1409

  Chen, Cheng Yu ^a   Willard, Devina ^a   Rudolph, Johannes ^b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; CATALYTIC CYSTEINES; CATALYTIC DOMAINS; CRITICAL FACTORS; DOMAIN-CONTAINING PROTEINS; GLUTHATHIONE; IN-VITRO; IN-VIVO; INTRACELLULAR SIGNALING PATHWAYS; OXIDATION YIELDS; OXIDATIVE INACTIVATIONS; PROTEIN-PROTEIN INTERACTIONS; PROTEIN-TYROSINE PHOSPHATASE; REDOX REGULATIONS; REDUCTANTS; REVERSIBLE OXIDATIONS; SRC HOMOLOGY 2 DOMAINS; THIOREDOXIN;

AMIDES; AMINES; AMINO ACIDS; ORGANIC ACIDS; OXIDATION; PACKET NETWORKS; RATE CONSTANTS;

CATALYTIC OXIDATION;

AMIDE; AMINO ACID; CYSTEINE; DISULFIDE; DITHIOTHREITOL; GLUTATHIONE; NITROGEN; PROTEIN TYROSINE PHOSPHATASE SHP; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; REDUCING AGENT; THIOREDOXIN;

ARTICLE; CATALYSIS; CHEMICAL BOND; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME REGULATION; ENZYME STABILITY; IN VITRO STUDY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION;

BIOCATALYSIS; CATALYTIC DOMAIN; CYSTEINE; DISULFIDES; DITHIOTHREITOL; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; KINETICS; MUTAGENESIS; MUTANT PROTEINS; OXIDATION-REDUCTION; SH2 DOMAIN-CONTAINING PROTEIN TYROSINE PHOSPHATASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN-DISULFIDE REDUCTASE; THIOREDOXINS; TIME FACTORS;

EID: 64349117191     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801973z     Document Type: Article

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