Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 6, 1996, Pages 2493-2498

  Denu, John M ^a   Lohse, Daniel L ^a   Vijayalakshmi, J ^b   Saper, Mark A ^a,b   Dixon, Jack E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; CYSTEINE; PHOSPHATASE; PHOSPHATE; PROTEIN TYROSINE PHOSPHATASE; SERINE; VANADIC ACID;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; HYDROLYSIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON TRANSPORT; X RAY ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN-TYROSINE-PHOSPHATASE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VANADATES; YERSINIA;

EID: 0029917244     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.6.2493     Document Type: Article

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