The efficacy of raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering

Journal of Biological Chemistry

Volumn 289, Issue 14, 2014, Pages 9519-9533

  Guzmán, Camilo ^a   Šolman, Maja ^a   Ligabue, Alessio ^a   Blaževitš, Olga ^a   Andrade, Débora M ^b   Reymond, Luc ^c   Eggeling, Christian ^b,d   Abankwa, Daniel ^a  

^a TURKU CENTRE FOR BIOTECHNOLOGY   (Finland)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c EPFL   (Switzerland)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CONFORMATIONS; NANOCLUSTERS; PROTEINS; SCAFFOLDS (BIOLOGY); SIGNALING;

BIOCHEMICAL DATA; COMPUTATIONAL MODEL; CYTOPLASMIC LEVELS; FLUORESCENCE METHOD; GALECTIN-1; MAMMALIAN CELLS; SOLUTION STRUCTURES; SUPER RESOLUTION;

MEMBRANES;

GALECTIN 1; GUANOSINE TRIPHOSPHATASE; H RAS PROTEIN; RAF PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA HELIX; ANIMAL CELL; ARTICLE; CELL MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; FLUORESCENCE; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUORESCENCE LIFETIME IMAGING MICROSCOPY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FLUORESCENCE RESONANCE ENERGY TRANSFER; IN VITRO STUDY; MATHEMATICAL MODEL; MICROSCOPY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAS BINDING DOMAIN; SIGNAL TRANSDUCTION; STIMULATED EMISSION DEPLETION MICROSCOPY;

CANCER; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING (FRAP); FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); FLUORESCENCE-LIFETIME MICROSCOPY IMAGING (FLIM); MEMBRANE; NANOCLUSTER; RAS; SIGNALING; STIMULATED EMISSION DEPLETION (STED);

ANIMALS; CELL LINE; CELL MEMBRANE; CRICETINAE; GALECTIN 1; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NEOPLASMS; ONCOGENE PROTEIN P21(RAS); PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RAF KINASES; SIGNAL TRANSDUCTION;

EID: 84898063580     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.537001     Document Type: Article

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