Ras conformational switching: Simulating nucleotide- dependent conformational transitions with accelerated molecular dynamics

PLoS Computational Biology

Volumn 5, Issue 3, 2009, Pages

  Grant, Barry J ^a   Gorfe, Alemayehu A ^a   McCammon, J Andrew ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CELL SIGNALING; MOLECULAR DYNAMICS; REACTION INTERMEDIATES; REACTION KINETICS;

ACCELERATED MOLECULAR DYNAMICS; BARRIER-CROSSING; C-TERMINUS; CLASSICAL MOLECULAR DYNAMICS; CONFORMATIONAL SWITCHING; CONFORMATIONAL TRANSITIONS; CORRELATED MOTIONS; DYNAMICS SIMULATION; NUCLEOTIDE-BINDING SITES; REACTION PATHS;

NUCLEOTIDES;

AMINO ACID; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; NUCLEOTIDE; RAS PROTEIN;

ARTICLE; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; GENE MAPPING; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; ULTRASTRUCTURE;

BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; MODELS, CHEMICAL; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RAS PROTEINS;

EID: 63549096871     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000325     Document Type: Article

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