Nonsteroidal anti-inflammatory drugs alter the spatiotemporal organization of Ras proteins on the plasma membrane

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16586-16595

  Zhou, Yong ^a   Cho, Kwang Jin ^a   Plowman, Sarah J ^a   Hancock, John F ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN CYTOSKELETON; AMPHIPHILICS; ANTI-INFLAMMATORY AGENTS; CELL SIGNALING; COMPLEX EFFECTS; DRUG ACTION; INDIVIDUAL AGENT; INDOMETHACIN; INNER LEAFLETS; KINASE ACTIVATION; LATERAL SEGREGATION; MAPK SIGNALING; MEMBRANE PHOSPHOLIPIDS; NANO SCALE; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; PARTITION COEFFICIENT; PLASMA MEMBRANE HETEROGENEITY; SMALL BIOLOGICAL MOLECULE; SPATIAL ORGANIZATION; SPATIO-TEMPORAL ORGANIZATION;

AMPHIPHILES; CELL MEMBRANES; CHEMICAL ACTIVATION; CHOLESTEROL; DRUG PRODUCTS; NANOCLUSTERS; PHOSPHOLIPIDS;

PROTEINS;

ACETYLSALICYLIC ACID; CHOLESTEROL; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; H RAS PROTEIN; IBUPROFEN; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE; N RAS PROTEIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; RAF PROTEIN; RAS PROTEIN; SALICYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL MEMBRANE; CHOLESTEROL; CRICETINAE; INDOMETHACIN; MEMBRANE PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 84860857782     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.348490     Document Type: Article

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