Galectin-1 is a novel structural component and a major regulator of H-Ras nanoclusters

Molecular Biology of the Cell

Volumn 19, Issue 4, 2008, Pages 1404-1414

  Belanis, Liron ^a   Plowman, Sarah J ^b   Rotblat, Barak ^a   Hancock, John F ^b   Kloog, Yoel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GALECTIN 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; GOLGI COMPLEX; HUMAN; HUMAN CELL; ONCOGENE H RAS; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL MEMBRANE; CRICETINAE; EPIDERMAL GROWTH FACTOR; GALECTIN 1; GOLGI APPARATUS; HUMANS; LIPOYLATION; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; NANOPARTICLES; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 44949124597     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-10-1053     Document Type: Article

References (36)

1. Apolloni, A., Prior, I. A., Lindsay, M., Parton, R. G., and Hancock, J. F. (2000). H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol. Cell. Biol. 20, 2475-2487.
2. Ashery, U., Yizhar, O., Rotblat, B., Elad-Sfadia, G., Barkan, B., Haklai, R., and Kloog, Y. (2006). Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch. Cell. Mol. Neurobiol. 26, 469-493.
3. Bivona, T. G. et al. (2006). PKC regulates a farnesyl- electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol. Cell 21, 481-493.
4. Bracha-Drori, K., Shichrur, K., Katz, A., Oliva, M., Angelovici, R., Yalovsky, S., and Ohad, N. (2004). Detection of protein-protein interactions in plants using bimolecular fluorescence complementation. Plant J. 40, 419-427.
5. Chiu, V. K., Bivona, T., Hach, A., Sajous, J. B., Silletti, J., Wiener, H., Johnson, R. L., 2nd, Cox, A. D., and Philips, M. R. (2002). Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4, 343-350.
6. Choy, E., Chiu, V. K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I. E., and Philips, M. R. (1999). Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98, 69-80.
7. Clayton, A. H., Hanley, Q. S., and Verveer, P. J. (2004). Graphical representation and multicomponent analysis of single-frequency fluorescence lifetime imaging microscopy data. J. Microsc. 213, 1-5.
8. Cox, A. D., and Der, C. J. (2003). The dark side of Ras: regulation of apoptosis. Oncogene 22, 8999-9006.
9. Diggle, P. J., Mateu, J., Clough, H. E. (2000). A comparison between parametric and non-parametric approaches to the analysis of replicated spatial point patterns. Adv. Appl. Prob. (SGSA) 32, 331-343.
10. Downward, J. (2003). Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways? Biochem. J. 376, e9-10.
11. Elad-Sfadia, G., Haklai, R., Ballan, E., Gabius, H. J., and Kloog, Y. (2002). Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase. J. Biol. Chem. 277, 37169-37175.
12. Esposito, A., Gerritsen, H. C., and Wouters, F. S. (2005). Fluorescence lifetime heterogeneity resolution in the frequency domain by lifetime moments analysis. Biophys. J. 89, 4286-4299.
13. Fridman, M., Maruta, H., Gonez, J., Walker, F., Treutlein, H., Zeng, J., and Burgess, A. (2000). Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras. J. Biol. Chem. 275, 30363-30371.
14. Goodwin, J. S., Drake, K. R., Rogers, C., Wright, L., Lippincott-Schwartz, J., Philips, M. R., and Kenworthy, A. K. (2005). Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J. Cell Biol. 170, 261-272.
15. Gorfe, A. A., Hanzal-Bayer, M., Abankwa, D., Hancock, J. F., and McCammon, J. A. (2007). Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer. J. Med. Chem. 50, 674-684.
16. Hancock, J. F., and Parton, R. G. (2005). Ras plasma membrane signalling platforms. Biochem. J. 389, 1-11.
17. Hancock, J. F., Paterson, H., and Marshall, C. J. (1990). A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63, 133-139.
18. Hu, C. D., Chinenov, Y., and Kerppola, T. K. (2002). Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation. Mol. Cell 9, 789-798.
19. Jaumot, M., Yan, J., Clyde-Smith, J., Sluimer, J., and Hancock, J. F. (2002). The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem. 277, 272-278.
20. Kenworthy, A. K. (2007). Nanoclusters digitize Ras signalling. Nat. Cell Biol. 9, 875-877.
21. Lobo, S., Greentree, W. K., Linder, M. E., and Deschenes, R. J. (2002). Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J. Biol. Chem. 277, 41268-41273.
22. Meder, D., and Simons, K. (2005). Cell biology. Ras on the roundabout. Science 307, 1731-1733.
23. Niv, H., Gutman, O., Henis, Y. I., and Kloog, Y. (1999). Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies. J. Biol. Chem. 274, 1606-1613.
24. Niv, H., Gutman, O., Kloog, Y., and Henis, Y. I. (2002). Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells. J. Cell Biol. 157, 865-872.
25. Ozalp, C., Szczesna-Skorupa, E., and Kemper, B. (2005). Bimolecular fluorescence complementation analysis of cytochrome p450 2c2, 2e1, and NADPH-cytochrome p450 reductase molecular interactions in living cells. Drug Metab. Dispos. 33, 1382-1390.
26. Paz, A., Haklai, R., Elad-Sfadia, G., Ballan, E., and Kloog, Y. (2001). Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 20, 7486-7493.
27. Plowman, S. J., Muncke, C., Parton, R. G., and Hancock, J. F. (2005). H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc. Natl. Acad. Sci. USA 102, 15500-15505.
28. Prior, I. A., Harding, A., Yan, J., Sluimer, J., Parton, R. G., and Hancock, J. F. (2001). GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3, 368-375.
29. Prior, I. A., Muncke, C., Parton, R. G., and Hancock, J. F. (2003). Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J. Cell Biol. 160, 165-170.
30. Rocks, O., Peyker, A., Kahms, M., Verveer, P. J., Koerner, C., Lumbierres, M., Kuhlmann, J., Waldmann, H., Wittinghofer, A., and Bastiaens, P. I. (2005). An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science 307, 1746-1752.
31. Rotblat, B., Niv, H., Andre, S., Kaltner, H., Gabius, H. J., and Kloog, Y. (2004a). Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res. 64, 3112-3118.
32. Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I., and Hancock, J. F. (2004b). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol. Cell. Biol. 24, 6799-6810.
33. Roy, S., Plowman, S., Rotblat, B., Prior, I. A., Muncke, C., Grainger, S., Parton, R. G., Henis, Y. I., Kloog, Y., and Hancock, J. F. (2005). Individual palmitoyl residues serve distinct roles in h-ras trafficking, microlocalization, and signaling. Mol. Cell. Biol. 25, 6722-6733.
34. Swarthout, J. T., Lobo, S., Farh, L., Croke, M. R., Greentree, W. K., Deschenes, R. J., and Linder, M. E. (2005). DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J. Biol. Chem. 280, 31141-31148.
35. Tian, T., Harding, A., Inder, K., Plowman, S., Parton, R. G., and Hancock, J. F. (2007). Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nat. Cell Biol. 9, 905-914.
36. Verveer, P. J., and Bastiaens, P. I. (2003). Evaluation of global analysis algorithms for single frequency fluorescence lifetime imaging microscopy data. J. Microsc. 209, 1-7.