Raf inhibitors target ras spatiotemporal dynamics

Current Biology

Volumn 22, Issue 11, 2012, Pages 945-955

  Cho, Kwang Jin ^a   Kasai, Rinshi S ^b   Park, Jin Hee ^a   Chigurupati, Sravanthi ^a   Heidorn, Sonja J ^d   Van Der Hoeven, Dharini ^a   Plowman, Sarah J ^a   Kusumi, Akihiro ^b,c   Marais, Richard ^d   Hancock, John F ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL; ARTICLE; CHO CELL; CRICETULUS; DIMERIZATION; DRUG ANTAGONISM; HAMSTER; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS;

EID: 84861874745     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2012.03.067     Document Type: Article

References (45)

1. A. Kusumi, K.G. Suzuki, R.S. Kasai, K. Ritchie, and T.K. Fujiwara Hierarchical mesoscale domain organization of the plasma membrane Trends Biochem. Sci. 36 2011 604 615
2. I. Levental, M. Grzybek, and K. Simons Greasing their way: lipid modifications determine protein association with membrane rafts Biochemistry 49 2010 6305 6316
3. T. Tian, A. Harding, K. Inder, S. Plowman, R.G. Parton, and J.F. Hancock Plasma membrane nanoswitches generate high-fidelity Ras signal transduction Nat. Cell Biol. 9 2007 905 914
4. J.F. Hancock Lipid rafts: contentious only from simplistic standpoints Nat. Rev. Mol. Cell Biol. 7 2006 456 462
5. K. Simons, and D. Toomre Lipid rafts and signal transduction Nat. Rev. Mol. Cell Biol. 1 2000 31 39
6. B.N. Kholodenko, J.F. Hancock, and W. Kolch Signalling ballet in space and time Nat. Rev. Mol. Cell Biol. 11 2010 414 426
7. A.S. Harding, and J.F. Hancock Using plasma membrane nanoclusters to build better signaling circuits Trends Cell Biol. 18 2008 364 371
8. S.J. Plowman, C. Muncke, R.G. Parton, and J.F. Hancock H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton Proc. Natl. Acad. Sci. USA 102 2005 15500 15505
9. P.I. Poulikakos, and N. Rosen Mutant BRAF melanomas - dependence and resistance Cancer Cell 19 2011 11 15
10. E.W. Joseph, C.A. Pratilas, P.I. Poulikakos, M. Tadi, W. Wang, B.S. Taylor, E. Halilovic, Y. Persaud, F. Xing, and A. Viale The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner Proc. Natl. Acad. Sci. USA 107 2010 14903 14908
11. K.T. Flaherty, I. Puzanov, K.B. Kim, A. Ribas, G.A. McArthur, J.A. Sosman, P.J. O'Dwyer, R.J. Lee, J.F. Grippo, K. Nolop, and P.B. Chapman Inhibition of mutated, activated BRAF in metastatic melanoma N. Engl. J. Med. 363 2010 809 819
12. S.J. Heidorn, C. Milagre, S. Whittaker, A. Nourry, I. Niculescu-Duvas, N. Dhomen, J. Hussain, J.S. Reis-Filho, C.J. Springer, C. Pritchard, and R. Marais Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 2010 209 221
13. G. Hatzivassiliou, K. Song, I. Yen, B.J. Brandhuber, D.J. Anderson, R. Alvarado, M.J. Ludlam, D. Stokoe, S.L. Gloor, and G. Vigers RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth Nature 464 2010 431 435
14. P.I. Poulikakos, C. Zhang, G. Bollag, K.M. Shokat, and N. Rosen RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 2010 427 430
15. D.J. Anderson, J.K. Durieux, K. Song, R. Alvarado, P.K. Jackson, G. Hatzivassiliou, and M.J. Ludlam Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics PLoS ONE 6 2011 e22607
16. S.M. Wilhelm, C. Carter, L. Tang, D. Wilkie, A. McNabola, H. Rong, C. Chen, X. Zhang, P. Vincent, and M. McHugh BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis Cancer Res. 64 2004 7099 7109
17. S. Whittaker, D. Ménard, R. Kirk, L. Ogilvie, D. Hedley, A. Zambon, F. Lopes, N. Preece, H. Manne, and S. Rana A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF Cancer Res. 70 2010 8036 8044
18. S.J. Plowman, N. Ariotti, A. Goodall, R.G. Parton, and J.F. Hancock Electrostatic interactions positively regulate K-Ras nanocluster formation and function Mol. Cell. Biol. 28 2008 4377 4385
19. K.G. Suzuki, T.K. Fujiwara, M. Edidin, and A. Kusumi Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2 J. Cell Biol. 177 2007 731 742
20. K.G. Suzuki, T.K. Fujiwara, F. Sanematsu, R. Iino, M. Edidin, and A. Kusumi GPI-anchored receptor clusters transiently recruit Lyn and G alpha for temporary cluster immobilization and Lyn activation: single-molecule tracking study 1 J. Cell Biol. 177 2007 717 730
21. N. Nassar, G. Horn, C. Herrmann, A. Scherer, F. McCormick, and A. Wittinghofer The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue Nature 375 1995 554 560
22. A.K. Kenworthy Nanoclusters digitize Ras signalling Nat. Cell Biol. 9 2007 875 877
23. A. Harding, and J.F. Hancock Ras nanoclusters: combining digital and analog signaling Cell Cycle 7 2008 127 134
24. A. Mor, and M.R. Philips Compartmentalized Ras/MAPK signaling Annu. Rev. Immunol. 24 2006 771 800
25. V.K. Chiu, T. Bivona, A. Hach, J.B. Sajous, J. Silletti, H. Wiener, R.L. Johnson 2nd, A.D. Cox, and M.R. Philips Ras signalling on the endoplasmic reticulum and the Golgi Nat. Cell Biol. 4 2002 343 350
26. K. Inder, A. Harding, S.J. Plowman, M.R. Philips, R.G. Parton, and J.F. Hancock Activation of the MAPK module from different spatial locations generates distinct system outputs Mol. Biol. Cell 19 2008 4776 4784
27. H. Murakoshi, R. Iino, T. Kobayashi, T. Fujiwara, C. Ohshima, A. Yoshimura, and A. Kusumi Single-molecule imaging analysis of Ras activation in living cells Proc. Natl. Acad. Sci. USA 101 2004 7317 7322
28. J.F. Hancock, and R.G. Parton Ras plasma membrane signalling platforms Biochem. J. 389 2005 1 11
29. J. Hu, H. Yu, A.P. Kornev, J. Zhao, E.L. Filbert, S.S. Taylor, and A.S. Shaw Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF Proc. Natl. Acad. Sci. USA 108 2011 6067 6072
30. R. Shalom-Feuerstein, S.J. Plowman, B. Rotblat, N. Ariotti, T. Tian, J.F. Hancock, and Y. Kloog K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3 Cancer Res. 68 2008 6608 6616
31. T. Tian, S.J. Plowman, R.G. Parton, Y. Kloog, and J.F. Hancock Mathematical modeling of K-Ras nanocluster formation on the plasma membrane Biophys. J. 99 2010 534 543
32. R. Levy, M. Grafi-Cohen, Z. Kraiem, and Y. Kloog Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas Mol. Cancer Ther. 9 2010 2208 2219
33. M.C. Mendoza, E.E. Er, and J. Blenis The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Trends Biochem. Sci. 36 2011 320 328
34. L.M. Packer, S. Rana, R. Hayward, T. O'Hare, C.A. Eide, A. Rebocho, S. Heidorn, M.S. Zabriskie, I. Niculescu-Duvaz, and B.J. Druker Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia Cancer Cell 20 2011 715 727
35. L. Belanis, S.J. Plowman, B. Rotblat, J.F. Hancock, and Y. Kloog Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters Mol. Biol. Cell 19 2008 1404 1414
36. D. Abankwa, A.A. Gorfe, K. Inder, and J.F. Hancock Ras membrane orientation and nanodomain localization generate isoform diversity Proc. Natl. Acad. Sci. USA 107 2010 1130 1135
37. D. Abankwa, A.A. Gorfe, and J.F. Hancock Ras nanoclusters: molecular structure and assembly Semin. Cell Dev. Biol. 18 2007 599 607
38. A.H. Clayton, Q.S. Hanley, and P.J. Verveer Graphical representation and multicomponent analysis of single-frequency fluorescence lifetime imaging microscopy data J. Microsc. 213 2004 1 5
39. P.J. Verveer, and P.I. Bastiaens Evaluation of global analysis algorithms for single frequency fluorescence lifetime imaging microscopy data J. Microsc. 209 2003 1 7
40. A. Esposito, H.C. Gerritsen, and F.S. Wouters Fluorescence lifetime heterogeneity resolution in the frequency domain by lifetime moments analysis Biophys. J. 89 2005 4286 4299
41. J.F. Hancock, and I.A. Prior Electron microscopic imaging of Ras signaling domains Methods 37 2005 165 172
42. I.A. Prior, C. Muncke, R.G. Parton, and J.F. Hancock Direct visualization of Ras proteins in spatially distinct cell surface microdomains J. Cell Biol. 160 2003 165 170
43. B.D. Ripley Modelling spatial patterns J. R. Stat. Soc., B 39 1977 172 192
44. P.J. Diggle, J. Mateu, and H.E. Clough A comparison between parametric and non-parametric approaches to the analysis of replicated spatial point patterns Adv. Appl. Probab. 32 2000 331 343
45. S.J. Sahl, M. Leutenegger, M. Hilbert, S.W. Hell, and C. Eggeling Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids Proc. Natl. Acad. Sci. USA 107 2010 6829 6834