메뉴 건너뛰기




Volumn 7, Issue 9, 2012, Pages

A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; GUANOSINE TRIPHOSPHATE; LYSINE; NUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE BETA CLASS 2; PROTEIN KINASE B; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 84866375875     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045360     Document Type: Article
Times cited : (23)

References (45)
  • 2
    • 17944369909 scopus 로고    scopus 로고
    • Wildtype Kras2 can inhibit lung carcinogenesis in mice
    • Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, et al. (2001) Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet 29: 25-33.
    • (2001) Nat Genet , vol.29 , pp. 25-33
    • Zhang, Z.1    Wang, Y.2    Vikis, H.G.3    Johnson, L.4    Liu, G.5
  • 3
    • 0024154082 scopus 로고
    • The normal human H-ras1 gene can act as an onco-suppressor
    • Spandidos A, Wilkie NM (1988) The normal human H-ras1 gene can act as an onco-suppressor. Br J Cancer Suppl 9: 67-71.
    • (1988) Br J Cancer Suppl , vol.9 , pp. 67-71
    • Spandidos, A.1    Wilkie, N.M.2
  • 4
    • 0025520003 scopus 로고
    • Expression of the normal H-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes
    • Spandidos DA, Frame M, Wilkie NM, (1990) Expression of the normal H-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes. Anticancer Res 10: 1543-1554.
    • (1990) Anticancer Res , vol.10 , pp. 1543-1554
    • Spandidos, D.A.1    Frame, M.2    Wilkie, N.M.3
  • 5
    • 0036682167 scopus 로고    scopus 로고
    • The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene
    • Diaz R, Ahn D, Lopez-Barcons L, Malumbres M, Perez de Castro I, et al. (2002) The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res 62: 4514-4518.
    • (2002) Cancer Res , vol.62 , pp. 4514-4518
    • Diaz, R.1    Ahn, D.2    Lopez-Barcons, L.3    Malumbres, M.4    Perez de Castro, I.5
  • 6
    • 0030039909 scopus 로고    scopus 로고
    • Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: evidence for a new tumor suppressor gene on the short arm of chromosome 12
    • Takeuchi S, Mori N, Koike M, Slater J, Park S, et al. (1996) Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: evidence for a new tumor suppressor gene on the short arm of chromosome 12. Cancer Res 56: 738-740.
    • (1996) Cancer Res , vol.56 , pp. 738-740
    • Takeuchi, S.1    Mori, N.2    Koike, M.3    Slater, J.4    Park, S.5
  • 7
    • 0031776498 scopus 로고    scopus 로고
    • Prognostic value of loss of heterozygosity and KRAS2 mutations in lung adenocarcinoma
    • De Gregorio L, Manenti G, Incarbone M, Pilotti S, Pastorino U, et al. (1998) Prognostic value of loss of heterozygosity and KRAS2 mutations in lung adenocarcinoma. Int J Cancer 79: 269-272.
    • (1998) Int J Cancer , vol.79 , pp. 269-272
    • de Gregorio, L.1    Manenti, G.2    Incarbone, M.3    Pilotti, S.4    Pastorino, U.5
  • 8
    • 0032535003 scopus 로고    scopus 로고
    • Identification of 12p as a region of frequent deletion in advanced prostate cancer
    • Kibel AS, Schutte M, Kern SE, Isaacs WB, Bova GS, (1998) Identification of 12p as a region of frequent deletion in advanced prostate cancer. Cancer Res 58: 5652-5655.
    • (1998) Cancer Res , vol.58 , pp. 5652-5655
    • Kibel, A.S.1    Schutte, M.2    Kern, S.E.3    Isaacs, W.B.4    Bova, G.S.5
  • 9
    • 0003000807 scopus 로고    scopus 로고
    • Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases
    • Feig LA, (1999) Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases. Nat Cell Biol 1: E25-27.
    • (1999) Nat Cell Biol , vol.1
    • Feig, L.A.1
  • 10
    • 0023715225 scopus 로고
    • Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
    • Feig LA, Cooper GM, (1988) Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 8: 3235-3243.
    • (1988) Mol Cell Biol , vol.8 , pp. 3235-3243
    • Feig, L.A.1    Cooper, G.M.2
  • 11
    • 15844372678 scopus 로고    scopus 로고
    • Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors
    • Quilliam LA, Hisaka MM, Zhong S, Lowry A, Mosteller RD, et al. (1996) Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors. J Biol Chem 271: 11076-11082.
    • (1996) J Biol Chem , vol.271 , pp. 11076-11082
    • Quilliam, L.A.1    Hisaka, M.M.2    Zhong, S.3    Lowry, A.4    Mosteller, R.D.5
  • 12
    • 0034708781 scopus 로고    scopus 로고
    • The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation
    • Stewart S, Guan KL, (2000) The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation. J Biol Chem 275: 8854-8862.
    • (2000) J Biol Chem , vol.275 , pp. 8854-8862
    • Stewart, S.1    Guan, K.L.2
  • 13
    • 78650435425 scopus 로고    scopus 로고
    • INTERSECTINg Pathways in Cell Biology
    • O'Bryan JP, (2010) INTERSECTINg Pathways in Cell Biology. Sci Signal 3: re10.
    • (2010) Sci Signal , vol.3
    • O'Bryan, J.P.1
  • 14
    • 0032453895 scopus 로고    scopus 로고
    • Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1- >q22.2
    • Guipponi M, Scott HS, Hattori M, Ishii K, Sakaki Y, et al. (1998) Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1- >q22.2. Cytogenet Cell Genet 83: 218-220.
    • (1998) Cytogenet Cell Genet , vol.83 , pp. 218-220
    • Guipponi, M.1    Scott, H.S.2    Hattori, M.3    Ishii, K.4    Sakaki, Y.5
  • 15
    • 0032553443 scopus 로고    scopus 로고
    • Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
    • Yamabhai M, Hoffman NG, Hardison NL, McPherson PS, Castagnoli L, et al. (1998) Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem 273: 31401-31407.
    • (1998) J Biol Chem , vol.273 , pp. 31401-31407
    • Yamabhai, M.1    Hoffman, N.G.2    Hardison, N.L.3    McPherson, P.S.4    Castagnoli, L.5
  • 16
    • 0033106167 scopus 로고    scopus 로고
    • The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15
    • Sengar AS, Wang W, Bishay J, Cohen S, Egan SE, (1999) The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J 18: 1159-1171.
    • (1999) EMBO J , vol.18 , pp. 1159-1171
    • Sengar, A.S.1    Wang, W.2    Bishay, J.3    Cohen, S.4    Egan, S.E.5
  • 17
    • 0033603313 scopus 로고    scopus 로고
    • EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?
    • Okamoto M, Schoch S, Sudhof TC, (1999) EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? J Biol Chem 274: 18446-18454.
    • (1999) J Biol Chem , vol.274 , pp. 18446-18454
    • Okamoto, M.1    Schoch, S.2    Sudhof, T.C.3
  • 18
    • 0032983521 scopus 로고    scopus 로고
    • Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells
    • Hussain NK, Yamabhai M, Ramjaun AR, Guy AM, Baranes D, et al. (1999) Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J Biol Chem 274: 15671-15677.
    • (1999) J Biol Chem , vol.274 , pp. 15671-15677
    • Hussain, N.K.1    Yamabhai, M.2    Ramjaun, A.R.3    Guy, A.M.4    Baranes, D.5
  • 19
    • 52449109668 scopus 로고    scopus 로고
    • Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression
    • Chabu C, Doe CQ, (2008) Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression. Development 135: 2739-2746.
    • (2008) Development , vol.135 , pp. 2739-2746
    • Chabu, C.1    Doe, C.Q.2
  • 20
    • 34147121186 scopus 로고    scopus 로고
    • Intersectin links WNK kinases to endocytosis of ROMK1
    • He G, Wang HR, Huang SK, Huang CL, (2007) Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest 117: 1078-1087.
    • (2007) J Clin Invest , vol.117 , pp. 1078-1087
    • He, G.1    Wang, H.R.2    Huang, S.K.3    Huang, C.L.4
  • 21
    • 33751188950 scopus 로고    scopus 로고
    • Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
    • Martin NP, Mohney RP, Dunn S, Das M, Scappini E, et al. (2006) Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling. Mol Pharmacol 70: 1643-1653.
    • (2006) Mol Pharmacol , vol.70 , pp. 1643-1653
    • Martin, N.P.1    Mohney, R.P.2    Dunn, S.3    Das, M.4    Scappini, E.5
  • 22
    • 36048996570 scopus 로고    scopus 로고
    • Regulation of neuron survival through an intersectin-phosphoinositide 3′-kinase C2beta-AKT pathway
    • Das M, Scappini E, Martin NP, Wong KA, Dunn S, et al. (2007) Regulation of neuron survival through an intersectin-phosphoinositide 3′-kinase C2beta-AKT pathway. Mol Cell Biol 27: 7906-7917.
    • (2007) Mol Cell Biol , vol.27 , pp. 7906-7917
    • Das, M.1    Scappini, E.2    Martin, N.P.3    Wong, K.A.4    Dunn, S.5
  • 23
    • 0034282927 scopus 로고    scopus 로고
    • Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways
    • Adams A, Thorn JM, Yamabhai M, Kay BK, O'Bryan JP, (2000) Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways. J Biol Chem 275: 27414-27420.
    • (2000) J Biol Chem , vol.275 , pp. 27414-27420
    • Adams, A.1    Thorn, J.M.2    Yamabhai, M.3    Kay, B.K.4    O'Bryan, J.P.5
  • 24
    • 0344875509 scopus 로고    scopus 로고
    • Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK
    • Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, et al. (2003) Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem 278: 47038-47045.
    • (2003) J Biol Chem , vol.278 , pp. 47038-47045
    • Mohney, R.P.1    Das, M.2    Bivona, T.G.3    Hanes, R.4    Adams, A.G.5
  • 25
    • 80055101466 scopus 로고    scopus 로고
    • Bimolecular Fluorescence Complementation
    • Wong KA, O'Bryan JP (2011) Bimolecular Fluorescence Complementation. J Vis Exp: e2643.
    • (2011) J Vis Exp
    • Wong, K.A.1    O'Bryan, J.P.2
  • 26
    • 15644362968 scopus 로고    scopus 로고
    • Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity
    • Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, et al. (1998) Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem 273: 33082-33090.
    • (1998) J Biol Chem , vol.273 , pp. 33082-33090
    • Arcaro, A.1    Volinia, S.2    Zvelebil, M.J.3    Stein, R.4    Watton, S.J.5
  • 27
    • 42049116295 scopus 로고    scopus 로고
    • Visualization of protein interactions in living Caenorhabditis elegans using bimolecular fluorescence complementation analysis
    • Shyu YJ, Hiatt SM, Duren HM, Ellis RE, Kerppola TK, et al. (2008) Visualization of protein interactions in living Caenorhabditis elegans using bimolecular fluorescence complementation analysis. Nat Protoc 3: 588-596.
    • (2008) Nat Protoc , vol.3 , pp. 588-596
    • Shyu, Y.J.1    Hiatt, S.M.2    Duren, H.M.3    Ellis, R.E.4    Kerppola, T.K.5
  • 28
    • 33745785300 scopus 로고    scopus 로고
    • Visualization of molecular interactions by fluorescence complementation
    • Kerppola TK, (2006) Visualization of molecular interactions by fluorescence complementation. Nat Rev Mol Cell Biol 7: 449-456.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 449-456
    • Kerppola, T.K.1
  • 29
    • 17544384658 scopus 로고    scopus 로고
    • The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain
    • Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, et al. (2000) The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. EMBO J 19: 1263-1271.
    • (2000) EMBO J , vol.19 , pp. 1263-1271
    • Tong, X.K.1    Hussain, N.K.2    de Heuvel, E.3    Kurakin, A.4    Abi-Jaoude, E.5
  • 30
    • 0027250250 scopus 로고
    • Mammalian Ras interacts directly with the serine/threonine kinase Raf
    • Vojtek AB, Hollenberg SM, Cooper JA, (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74: 205-214.
    • (1993) Cell , vol.74 , pp. 205-214
    • Vojtek, A.B.1    Hollenberg, S.M.2    Cooper, J.A.3
  • 31
    • 0027502176 scopus 로고
    • Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins
    • Lai CC, Boguski M, Broek D, Powers S, (1993) Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins. Mol Cell Biol 13: 1345-1352.
    • (1993) Mol Cell Biol , vol.13 , pp. 1345-1352
    • Lai, C.C.1    Boguski, M.2    Broek, D.3    Powers, S.4
  • 32
    • 0028948382 scopus 로고
    • Multiple Ras functions can contribute to mammalian cell transformation
    • White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, et al. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell 80: 533-541.
    • (1995) Cell , vol.80 , pp. 533-541
    • White, M.A.1    Nicolette, C.2    Minden, A.3    Polverino, A.4    van Aelst, L.5
  • 33
    • 34249026448 scopus 로고    scopus 로고
    • Binding of Ras to Phosphoinositide 3-Kinase p110alpha Is Required for Ras- Driven Tumorigenesis in Mice
    • Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, et al. (2007) Binding of Ras to Phosphoinositide 3-Kinase p110alpha Is Required for Ras- Driven Tumorigenesis in Mice. Cell 129: 957-968.
    • (2007) Cell , vol.129 , pp. 957-968
    • Gupta, S.1    Ramjaun, A.R.2    Haiko, P.3    Wang, Y.4    Warne, P.H.5
  • 34
    • 0033635157 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
    • Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, et al. (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell 103: 931-943.
    • (2000) Cell , vol.103 , pp. 931-943
    • Pacold, M.E.1    Suire, S.2    Perisic, O.3    Lara-Gonzalez, S.4    Davis, C.T.5
  • 35
    • 0022472990 scopus 로고
    • Requirement for c-ras proteins during viral oncogene transformation
    • Smith MR, DeGudicibus SJ, Stacey DW, (19Requirement for c-ras proteins during viral oncogene transformation. Nature 320: 540-543.
    • (1986) Nature , vol.320 , pp. 540-543
    • Smith, M.R.1    DeGudicibus, S.J.2    Stacey, D.W.3
  • 36
    • 0025010979 scopus 로고
    • The GTPase superfamily: a conserved switch for diverse cell functions
    • Bourne HR, Sanders DA, McCormick F, (1990) The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348: 125-132.
    • (1990) Nature , vol.348 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 37
    • 0022587426 scopus 로고
    • Guanine nucleotides, protein phosphorylation and the control of translation
    • Proud CG, (1986) Guanine nucleotides, protein phosphorylation and the control of translation. Trends in Biochemical Sciences 11: 73-77.
    • (1986) Trends in Biochemical Sciences , vol.11 , pp. 73-77
    • Proud, C.G.1
  • 38
    • 33644864788 scopus 로고    scopus 로고
    • Compartmentalized Ras/MAPK signaling
    • Mor A, Philips MR, (2006) Compartmentalized Ras/MAPK signaling. Annu Rev Immunol 24: 771-800.
    • (2006) Annu Rev Immunol , vol.24 , pp. 771-800
    • Mor, A.1    Philips, M.R.2
  • 39
    • 84869503510 scopus 로고    scopus 로고
    • Intersectin 1 is required for neuroblastoma tumorigenesis
    • Russo A, O'Bryan JP (2012) Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene.
    • (2012) Oncogene
    • Russo, A.1    O'Bryan, J.P.2
  • 40
  • 41
    • 17144384463 scopus 로고    scopus 로고
    • Recognizing and defining true Ras binding domains I: biochemical analysis
    • Wohlgemuth S, Kiel C, Kramer A, Serrano L, Wittinghofer F, et al. (2005) Recognizing and defining true Ras binding domains I: biochemical analysis. J Mol Biol 348: 741-758.
    • (2005) J Mol Biol , vol.348 , pp. 741-758
    • Wohlgemuth, S.1    Kiel, C.2    Kramer, A.3    Serrano, L.4    Wittinghofer, F.5
  • 43
    • 2442689239 scopus 로고    scopus 로고
    • Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
    • Rodriguez-Viciana P, Sabatier C, McCormick F, (2004) Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24: 4943-4954.
    • (2004) Mol Cell Biol , vol.24 , pp. 4943-4954
    • Rodriguez-Viciana, P.1    Sabatier, C.2    McCormick, F.3
  • 44
    • 32444441115 scopus 로고    scopus 로고
    • PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
    • Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, et al. (2006) PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell 21: 481-493.
    • (2006) Mol Cell , vol.21 , pp. 481-493
    • Bivona, T.G.1    Quatela, S.E.2    Bodemann, B.O.3    Ahearn, I.M.4    Soskis, M.J.5
  • 45
    • 64049096198 scopus 로고    scopus 로고
    • A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
    • Lu A, Tebar F, Alvarez-Moya B, Lopez-Alcala C, Calvo M, et al. (2009) A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol 184: 863-879.
    • (2009) J Cell Biol , vol.184 , pp. 8
    • Lu, A.1    Tebar, F.2    Alvarez-Moya, B.3    Lopez-Alcala, C.4    Calvo, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.