Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?

British Journal of Pharmacology

Volumn 171, Issue 8, 2014, Pages 2206-2229

  Markham, A ^a   Bains, R ^b   Franklin, P ^a   Spedding, M ^c  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^c SPEDDING RESEARCH SOLUTIONS SARL   (France)

Author keywords

BDNF; calcium; glucocorticoids; mitochondria; neurodegenerative diseases; neurogenesis; plasticity; psychiatric disorders

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; GLUCOCORTICOID; MITOCHONDRIAL DNA; CALCIUM; NEUROPROTECTIVE AGENT;

APOPTOSIS; BIOGENESIS; BRAIN FUNCTION; BRAIN MITOCHONDRION; COGNITION; DEGENERATIVE DISEASE; DIETARY INTAKE; ELECTRON TRANSPORT; EXERCISE; GLYCOLYSIS; HUMAN; INFLAMMATION; MENTAL DISEASE; MOOD DISORDER; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; STRESS; AGING; ANIMAL; BIOLOGICAL MODEL; BRAIN; CALORIC INTAKE; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGING; ANIMALS; APOPTOSIS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM; COGNITION; ENERGY INTAKE; EXERCISE; GLUCOCORTICOIDS; HUMANS; MENTAL DISORDERS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL TURNOVER; MODELS, NEUROLOGICAL; NEURODEGENERATIVE DISEASES; NEUROGENESIS; NEURONAL PLASTICITY; NEUROPROTECTIVE AGENTS;

EID: 84897419410     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12531     Document Type: Review

References (244)

1. Albert MS, (1997). The ageing brain: normal and abnormal memory. Philos Trans R Soc Lond B Biol Sci 352: 1703-1709.
2. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P, (2002). BDNF activates CREB via activated protein kinase eliciting a gene transcription response. Available at: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=m (accessed 7/5/2013).
3. Alboni S, Tascedda F, Corsini D, Benatti C, Caggia F, Capone G, et al. (2011). Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice. Neuropharmacology 60: 1337-1346.
4. Andersson U, Scarpulla RC, (2001). Pgc-1-related co-activator, a novel serum inducible co-activator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol Cell Biol 21: 3738-3749.
5. Andrews ZB, Diano S, Horvath TL, (2005). Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci 6: 829-840.
6. Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HEW, et al. (2011). Little exercise, big effects reversing ageing and infection-induced memory deficits, and underlying processes. J Neurosci 31: 11578-11586.
7. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S, et al. (2006). Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 25: 3900-3911.
8. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 367: 795-804.
9. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Beicher-Timme C, Sonacki Y, et al. (2011). Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476: 341-345.
10. Baydoun AR, Markham A, Morgan RM, Sweetman AJ, (1988). Palmitoyl carnitine: an endogenous promoter of calcium efflux from rat heart mitochondria. Biochem Pharmacol 37: 3103-3107.
11. Baydoun AR, Markham A, Morgan RM, Sweetman AJ, (1990). Bay K8644 modifier of calcium transport and energy metabolism in rat mitochondria: a new intracellular site of action. Br J Pharmacol 101: 15-20.
12. Benard G, Bellance N, James D, Parrone P, Fernandez H, Letellier T, et al. (2007). Mitochondrial bioenergetics and structural network organisation. J Cell Sci 120: 838-848.
13. Ben-Shachar D, Karry R, (2008). Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar, disorder and major depression. PLoS ONE 3: e3676.
14. Bingwei L, (2009). Mitochondrial dynamics and neurodegeneration. Curr Neurol Neurosci Rep 9: 212-219.
15. Bredesen DE, Rao V, Mehlen P, (2006). Cell death in the nervous system. Nature 443: 706-766.
16. Brunelle JK, Letai A, (2009). Control of mitochondrial apoptosis by the Bcl-2. J Cell Sci 122: 437-441.
17. Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, et al. (2013). NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging Cell 12: 11-23.
18. Butow RA, Avadhani NG, (2004). Mitochondrial signaling: the retrograde response. Mol Cell 14: 1-15.
19. Cadenas E, Davies KJ, (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29: 222-230.
20. Cai Q, Sheng ZH, (2009). Mitochondrial transport and docking in axons. Exp Neurol 218: 257-267.
21. Cai Q, Davis ML, Sheng ZH, (2011). Regulation of axonal mitochondrial transport and its impact on synaptic transmission. Neurosci Res 70: 1-15.
22. Calabrese V, Cornellus C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP, (2010). Cellular stress response, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal 13: 1763-1811.
23. Caldeira MV, Melo CV, Pereira DB, Carvaiho RF, Corvalho AL, Duarte CB, (2007a). BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Mol Cell Neurosci 35: 208-219.
24. Caldeira MV, Melo CV, Pereira DB, Carvalho R, Correia SS, Beckos DS, et al. (2007b). Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons. J Biol Chem 282: 12619-12628.
25. 2+ as key regulator of mitochondrial activities. Advances in mitochondrial medicine. Adv Exp Med Biol Ser 942: 53-73.
26. 2+ and neurogeneration. Cell Calcium 52: 73-85.
27. Cassarino DS, Bennett JP Jr, (1999). An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res Rev Res Rev 29: 1-25.
28. Castren E, Voikar V, Rantamaki T, (2007). Role of neurotrophic factors in depression. Curr Opin Pharmacol 7: 18-21.
29. Chada SR, Hollenberck PJ, (2004). Nerve growth factor signalling regulates motility and docking of axonal mitochondria. Curr Biol 14: 1272-1276.
30. Chang DT, Reynolds IJ, (2006). Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Neuroscience 141: 727-736.
31. Chauhan D, Velankar M, Brahmandam M, Hideshima T, Podar K, Richardson P, et al. (2007). A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene 26: 2374-2380.
32. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT, (2001). Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50: 260-265.
33. Chen DY, Bambah-Mukku D, Pollonini G, Alberini CM, (2012). Glucocorticoid receptors recruit the CaMKllα-BDNF-CREB pathways to mediate memory consolidation. Nat Neurosci 15: 1707-1714.
34. Chen Z, Zhong C, (2013). Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Prog Neurobiol 108: 21-43.
35. Cheng A, Hou Y, Mattson MP, (2010a). Mitochondria and neuroplasticity. ASN Neuro 2: 243-256.
36. Cheng B, Mattson MP, (1994). NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res 640: 56-67.
37. Cheng G, Henter ID, Manji HK, (2010b). Translational research in bipolar disorder: emerging insights from genetically based models. Mol Psychiatry 15: 883-895.
38. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR, (2010). The BCL-2 family reunion. Mol Cell 37: 299-310.
39. Cohen BH, Gold DR, (2001). Mitochondrial cytopathy in adults: what we know so far. Cleve Clin J Med 68: 625-626.
40. Cohen S, Levi-Montalcini R, Hamburger V, (1954). A nerve growth-stimulating factor isolated from sarcom as 37 and 180. Proc Natl Acad Sci U S A 40: 1014-1018.
41. Cooke SF, Bliss TV, (2006). Plasticity in the human central nervous system. Brain 129: 1659-1673.
42. Costa V, Giacomello M, Hudec R, Lopreiato G, Ermal G, et al. (2010). Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med 2: 490-503.
43. Counts SE, Mufson EJ, (2010). Noraderenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity. J Neurochem 113: 649-660.
44. Cowell RM, Blake KR, Russell JW, (2007). Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain. J Comp Neurol 502: 1-18.
45. Creson TK, Yuan P, Manji HK, Chen G, (2009). Evidence for involvement of ERK, Pl3K, and RSK in induction of Bcl-2 by valproate. J Mol Sci 37: 123-134.
46. Cuimsee C, Mattson MP, (2005). p53 in neuronal apoptosis. Biochem Biophys Res Commun 331: 761-777.
47. Czeh B, Lucassen PJ, (2007). What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? Eur Arch Psychiatry Clin Neurosci 257: 250-260.
48. De Brito OM, Scorrano L, (2008). Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456: 605-610.
49. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R, (2011). A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476: 336-340.
50. Del BR, Moggio M, Rango M, D'Angelo MG, Ghezzi S, et al. (2008). Mutated mitofusion 2 presents with intrafamilial variability and brain mitochondrial dysfunction. Neurology 71: 1959-1966.
51. Deng W, Aimone JB, Gage FH, (2010). New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11: 339-350.
52. Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, et al. (2003). Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology 144: 5014-5021.
53. Dicou E, Rangon CM, Guimiot F, Spedding M, Gressens P, (2003). Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res 970: 221-225.
54. Diogenes MJ, Costenia AR, Lopes LV, Jeronimo-Santos A, Sousa VC, Fontinha BM, et al. (2011). Enhancement of LTP in aged rats is dependent on endogenous BDNF. Neuropsychopharmacology 36: 1823-1836.
55. Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW, et al. (2010). Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. J Alzheimers Dis 20: S535-S550.
56. Du H, Guo L, Fang F, Chen D, Sosunvo AA, McKhann GM, et al. (2008). Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memort in Alzheimer's disease. Nat Med 14: 1097-1105.
57. Du J, Wang Y, Hunter R, Wei Y, Blumenthal R, Falke C, et al. (2009). Dynamic regulation of mitochondrial function by glucocorticoids. Proc Natl Acad Sci U S A 106: 3543-3548.
58. Duchen MR, (1999). Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J Physiol 516: 1-17.
59. Einat H, Yuan P, Manji HK, (2005). Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav Brain Res 165: 172-180.
60. Fahnestock M, Marchese M, Head E, Pop V, Michaiski B, Milgram WN, et al. (2012). BDNF increases with behavioural enrichment and an antioxidant diet in the aged dog. Neurobiol Aging 33: 546-554.
61. Favalli G, Li J, Belmonte-de-Abreu P, Wong AHC, Daskalakis ZJ, (2012). The role of BDNF in the pathophysiology and treatment of schizophrenia. J Psychiatr Res 46: 1-11.
62. Fehm HL, Kern W, Peters A, (2006). The selfish brain: competition for energy resources. Prog Brain Res 153: 129-140.
63. Ferreiro E, Oliveira CR, Pereira CM, (2008). The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol Dis 30: 331-342.
64. Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B, (1996). Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381: 706-709.
65. Floyd RA, Hensley K, (2002). Oxidative stress in brain ageing. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23: 795-807.
66. Fox RM, Markham A, Morgan RM, (1993). Calcium antagonists and Bay K8644 promote depolarization of rat heart mitochondrial membrane potential. Further evidence for a role in alteration of oxidative metabolism. Biochem Pharmacol 45: 1995-2001.
67. Galeffi F, Somjen GG, Foster KA, Turner DA, (2011). Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen ulitization and mitochondrial redox state in rat hippocampal slices. J Cereb Blood Flow Metab 31: 626-639.
68. Gallagher M, Burwell R, Burchinal M, (1993). Severity of spatial learning impairment in ageing: development of a learning index for performance in the Morris water maze. Behav Neurosci 28: 8945-8954.
69. Garcia DA, Franke H, Pissarek M, Nieber K, Illes P, (1999). Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia. Neurosci Lett 273: 13-16.
70. Gavillet M, Allaman I, Magistretti PJ, (2008). Modulation of astrocytic metabolic phenotype by proinflammatory cytokines. Glia 56: 975-989.
71. 2+ as a key regulator of cell life and death. Cell Death Differ 14: 1267-1274.
72. Gibson GE, Starkvo A, Biass JP, Ratan RR, Beal MF, (2010). Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioural abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta 1802: 122-134.
73. Gleichmann M, Mattson MP, (2011). Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal 14: 1261-1273.
74. Godsil BP, Kiss JP, Spedding M, Jay TM, (2013). The hippocampal- prefrontal pathway: the weak link in psychiatric disorders? Eur Neuropsychopharmacol 23: 1165-1181.
75. Gong Y, Chai Y, Ding JH, Sun XL, Hu G, (2011). Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett 488: 76-80.
76. Gottmann K, Mittmann T, Lessmann V, (2009). BDNF signalling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res 199: 203-234.
77. Greenamyre JT, MacKenzie G, Peng TI, Stephans SE, (1999). Mitochondrial dysfunction in Parkinson's disease. Biochem Soc Symp 66: 85-97.
78. Gressens P, Marret S, Hill JM, Brenneman DE, Gozes I, Fridkin M, et al. (1997). Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain. J Clin Invest 100: 390-397.
79. Gutman M, Singer TP, Casida JE, (1970). Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase: XVII Reaction sites of piericidin A and rotenone. J Biol Chem 245: 1992-1997.
80. Gutsaeva DR, Carraway MS, Suliman HB, Demchenko IT, Shitara H, Yonekawa H, et al. (2008). Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci 28: 2015-2024.
81. Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Llijic E, Shumacker PT, et al. (2010). Oxidative stress evoked by pace-making in dopaminergic neurons is attenuated by DJ-1. Nature 468: 696-700.
82. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, et al. (2008). The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9: 857-865.
83. Halliwell B, (2006). Oxidative stress and neurodegeneration: where are we now? J Neurochem 97: 1634-1658.
84. Han BH, Holtzman DM, (2000). BDNF protects the neonatal brain from hypoxia-ischemic injury in vivo via ERK pathway. J Neurosci 20: 5775-5781.
85. Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, Tomizawa K, et al. (2008). CaM kinase 1α-induced phosphorylation of Drp1 regulates mitochondrial morthology. J Cell Biol 182: 573-585.
86. Hansson AC, Cintra A, Belluardo N, Sommer W, Bhatnagar M, Bader M, et al. (2000). Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat. Eur J Neurosci 12: 2918-2934.
87. Harper ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio M, et al. (2002). Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J 16: 1550-1557.
88. Harper MM, Adamson L, Blits B, Bunge MB, Grozdanic SD, Sakaguchi DS, (2009). Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells. Exp Eye Res 89: 538-548.
89. Hartl FU, Bracher A, Hayer-Hartl M, (2011). Molecular chaperones in protein folding and proteostasis. Nature 475: 324-332.
90. Hebert TL, Wu X, Yu G, Goh BC, Halvorsen YD, Wang Z, et al. (2009). Culture effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on cryopreserved human adipose-derived stromal/stem cell proliferation and adipogenesis. J Tissue Eng Regen Med 3: 553-561.
91. Hempstead BL, Lee R, Kermani P, Teng KK, (2001). Regulation of cell survival by secreted proneurotrophins. Science 294: 1945-1948.
92. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, et al. (2013). NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493: 674-678.
93. Hetman M, Kanning K, Cavanaugh JE, Xia Z, (1999). Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 274: 22569-22580.
94. Hickman JA, Hardwick JM, Kaczmarek LK, Jonas EA, (2008). Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. J Neurophysiol 99: 1515-1522.
95. Hildebrandt H, Muhienhoff M, Weinhold B, Gerardy-Schahn R, (2007). Dissecting polysialic acid and NCAM function in brain development. J Neurochem 103: 56-64.
96. Holley AK, Dhar SK, St Clair DK, (2010). Manganese superoxide dismutase versus p53: the mitochondrial centre. Ann N Y Acad Sci 1201: 72-78.
97. Holt IJ, Harding AE, Morgan-Hughes JA, (1988). Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717-719.
98. Horvath TL, Diano S, Barnstable C, (2003). Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem Pharmacol 65: 1917-1921.
99. Hroudova J, Fisar Z, (2011). Connectivity between mitochondrial functions and psychiatric disorders. Psychiatry Clin Neurosci 65: 130-141.
100. Hunsberger J, Austin DR, Henter ID, Chen G, (2009). The neurotrophic and neuroprotective effects of psychotropic agents. Dialogues Clin Neurosci 11: 333-348.
101. Husson I, Mesples B, Bac P, Vamecq J, Evrard P, Gressens P, (2002). Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. Ann Neurol 51: 82-92.
102. Hyman C, Hofer M, Barde Y, Juhasz M, Yancopoulos GD, Squinto SP, et al. (1991). BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230-232.
103. Jahani-Asl A, Cheung EC, Neuspiel M, Maclaurin JG, Fortin A, et al. (2007). Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. J Biol Chem 282: 23788-23798.
104. Jahani-Asl A, Germain M, Slack RS, (2010). Mitochondria: joining forces to thwart cell death. Biochim Biophys Acta 1802: 162-166.
105. Jeanneteau F, Chao AV, (2012). Are BDNF and glucocorticoid activities calibrated? Neuroscience 239: 173-195.
106. Jendrach M, Pohl S, Voth M, et al. (2005). Morphology-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev 126: 813-821.
107. Jiang M, Wang J, Fu J, Du L, Jeong H, West T, et al. (2011). Neuroprotective role of Sirt1 in mammalian models of Huntingdon's disease through activation of multiple Sirt1 targets. Nat Med 18: 153-158.
108. Jiao S, Li Z, (2011). Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission. Neuron 70: 758-772.
109. Jonas E, (2006). BCL-xL regulates synaptic plasticity. Mol Interv 6: 208-222.
110. Kalb R, (2005). The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci 28: 5-11.
111. Kapogiannis D, Mattson MP, (2011). Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol 10: 187-198.
112. Kato T, (2001). The other, forgotten genome: mitochondrial DNA and metal disorders. Mol Psychiatry 6: 625-633.
113. Kim HW, Rapoport SI, Rao JS, (2010). Altered expression of apoptotic factors and synaptic markers in postmortembrain from bipolar disorder patients. Neurobiol Dis 37: 596-603.
114. Kohara K, Yasuda H, Huang Y, Adachi N, Sohya K, Tsumoto TA, (2007). A local reduction in cortical GABAergic synapses after loss of endogenous brain-derived neurotrophic factor, as revealed by single-cell gene knock-out method. J Neurosci 27: 7234-7244.
115. Kompagne H, Bardos G, Szenasi G, Gacsalyi I, Harsing LG, Levay G, (2008). Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. Behav Brain Res 193: 311-314.
116. Koo JW, Duman RS, (2008). IL-1beta is an essential mediator of antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 105: 751-756.
117. Koufali MM, Moutsatsou P, Sekeris CE, Breen BC, (2003). The dynamic localisation of the glucocorticoid receptor in rat C6 glioma cell mitochondria. Mol Cell Endocrinol 209: 51-60.
118. Kraft AD, Johnson DA, Johnson JA, (2004). Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci 24: 1101-1112.
119. Kroemer G, Reed JC, (2000). Mitochondrial control of cell death. Nat Med 6: 513-519.
120. Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izuni A, Niyaz M, et al. (2008). Glucocorticoids prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 22: 546-558.
121. Kumamaru E, Numakawa T, Adachi N, Kunugi H, (2011). Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB. FEBS Lett 585: 3224-3228.
122. LaFerla FM, Green KN, Oddo S, (2007). Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8: 499-509.
123. Laske C, Stransky E, Leyhe T, Eschweiler GW, Wittorf A, Richartz E, (2006). Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm 113: 1217-1224.
124. Lazarov O, Mattson MP, Peterson DA, Pimplikar SW, van Praag H, (2010). When neurogenesis encounters ageing and disease. Trends Neurosci 33: 569-579.
125. Leadsham JE, Gourley CW, (2010). cAMP/PKA signalling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation. BMC Cell Biol 11: 92-105.
126. Lee J, Duan W, Mattson MP, (2002). Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82: 1367-1375.
127. Lee J, Lim E, Kim Y, Li E, Park S, (2010). Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Endocrinol 205: 263-270.
128. Levi-Montalcini R, Hamburger V, (1953). A diffusible agent of mouse sarcoma producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo. J Exp Zool 123: 233-278.
129. Li H, Chen Y, Jones AF, Sanger RH, Collis LP, Flannery R, et al. (2008). Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci U S A 105: 2169-2174.
130. Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, et al. (2010). Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 141: 859-871.
131. Lipsky RH, Marini AM, (2007). Brain-derived neurotrophic factor in neuronal survival and behaviour-related plasticity. Ann N Y Acad Sci 1122: 130-143.
132. Liu W, Zhou C, (2012). Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. Psychoneuroendocrinology 37: 1057-1070.
133. 2+-dependent regulation of mitochondrial dynamics by Miro-Milton complex. Int J Biochem Cell Biol 41: 1972-1976.
134. Loers G, Schachner M, (2007). Recognition molecules and neural repair. J Neurochem 101: 865-882.
135. Lu Y, Christian K, Lu B, (2008). BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89: 312-323.
136. Lucca G, Comim CM, Valvassori SS, Reus GZ, Vuolo F, Petronillho F, et al. (2009). Effects of chronic mild stress on the oxidative parameters in rat brain mitochondria. Neurochem Int 54: 358-362.
137. Lynch MA, (2004). Long-term potentiation and memory. Physiol Rev 84: 87-136.
138. MacAskill AF, Kittler JT, (2010). Control of mitochondrial transport and localization in neurons. Trends Cell Biol 20: 102-112.
139. 2+ in signal transduction in mammalian tissues. Biochim Biophys Acta 1018: 287-291.
140. McKernan DP, Dinan TG, Cryan JF, (2009). 'Killing the Blues': a role for cellular suicide (apoptosis) in depression and the antidepressant response? Prog Neurobiol 88: 246-263.
141. Mammucari C, Patron M, Granatiero V, Rizzuto R, (2011). Molecules and roles of mitochondrial calcium signaling. Biofactors 37: 219-227.
142. Man HY, Lin JW, Ahmadian G, Liu L, Becker LE, et al. (2000). Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron 25: 649-662.
143. Manji H, Kato T, DiProspero NA, Ness S, Beal MF, Krams M, et al. (2012). Impaired mitochondrial function in psychiatric disorders. Nat Rev Neurosci 13: 293-307.
144. Manoli I, Salvatore A, Blackman MR, Su YA, Rennert OM, Chrousos GP, (2007). Mitochondria as key components of the stress response. Trends Endocrinol Metab 18: 190-198.
145. Manzanero S, Gelderblom M, Magnus T, Arumugan TV, (2011). Calorie restriction and stroke. Exp Transl Stroke Med 3: 8-21.
146. Marini AM, Jiang X, Wu X, Pan H, Guo Z, Mattson MP, et al. (2007). Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli. Amino Acids 32: 299-304.
147. Markham A, Cameron I, Franklin P, Spedding M, (2004). BDNF increases brain mitochondrial respiratory coupling, and glutamate metabolism, at complex I, but not complex II Eur J Neurosci 20: 1189-1196.
148. Markham A, Cameron I, Franklin P, Spedding M, (2005). BDNF, but not GDNF, increases mouse brain mitochondrial respiratory coupling at complex I, but not complex II Proceedings of British Pharmacological Society. Available at: http://www.pA2online.org/abstracts/Vol2Issue4abst105P.pdf (accessed 11/3/2013).
149. Markham A, Cameron I, Bains R, Franklin P, Kiss JP, Schwendenimann L, et al. (2012). Brain-derived neurotrophic factor-mediated effects on mitochondrial coupling and neuroprotection share the same molecular signalling pathways. Eur J Neurosci 35: 366-374.
150. Marlatt MW, Potter MC, Lucassen PJ, van Praag H, (2012). Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice. Dev Neurobiol 72: 943-952.
151. Marongiu R, Spencer B, Crews L, Adame A, Patrick C, et al. (2009). Mutant PINK1 induces mitochondrial dysfunction in neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem 108: 1561-1574.
152. Matrone C, Ciotti MT, Mercanti D, Marolda R, Calissano P, (2008). NGF and BDNF signalling control amyloidogenic route and Abeta production in hippocampal neurons. Proc Natl Acad Sci U S A 105: 13139-13144.
153. Matsumoto T, Rauskolb S, Polack M, Klose J, Kolbeck R, Korte M, et al. (2008). Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci 11: 131-133.
154. Mattson MP, (2008). Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 1144: 97-112.
155. Mattson MP, (2009). Roles of the lipid peroxidation product 4-hydroxynonenalin obesity, the metabolic syndrome and associated vascular and neurodegenerative disorders. Exp Gerontol 44: 625-633.
156. Mattson MP, Magnus T, (2006). Aging and neuronal vulnerability. Nat Rev Neurosci 7: 278-294.
157. Mattson MP, Partin J, (1999). Evidence for mitochondria control of neuronal polarity. J Neurosci Res 56: 8-20.
158. Mattson MP, Gleichmann M, Cheng A, (2008). Mitochondria in neuroplasticity and neurological disorders. Neuron 60: 748-766.
159. Miller RJ, (1998). Mitochondria-the Kraken wakes! Trends Neurosci 21: 95-97.
160. Minichiello L, Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M, (2002). Mecahanism of TrkB-mediated long-term potentiation. Neuron 36: 121-137.
161. Morimoto RI, (2008). Proteotoxic stess and inducible chaperone networks in neurodegenerative disease and ageing. Genes Dev 22: 1427-1437.
162. Murray PS, Holmes PV, (2011). An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus. Int J Pept 2011: Article ID 654085.
163. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, et al. (2009). Neuroprotective effects of brain-derived neurotrophic factorin rodent and primate models of Alzheimer's disease. Nat Med 15: 331-337.
164. Nagappan G, Lu B, (2005). Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci 28: 464-471.
165. Naoi M, Maruyama W, Akao Y, Yi H, Yamaoka Y, (2006). Involvement of type A monoamine oxidase in neurodegeneration of mitochondrial signalling leading to cell death or neuroprotection. J Neural Transm Suppl 71: 67-77.
166. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM, (2002). Neurobiology of depression. Neuron 34: 13-25.
167. Nicholls DG, (2009). Mitochondrial calcium function and dysfunction in the central nervous system. Biochim Biophys Acta 1787: 1416-1424.
168. Niciu MJ, Ionescu DF, Mathews DC, Richards EM, Zarate CA Jr, (2013). Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechamism of action, part II: bipolar disorder. CNS Spectr 18: 242-251.
169. Noakes T, Spedding M, (2012). Run for your life. Nature 487: 295-296.
170. Nuytemans K, Theuns J, Cruts M, Van Broeckhoven C, (2010). Genetic etiology of Parkinson's disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat 31: 763-780.
171. Oliveira JM, (2010). Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum. J Neurochem 114: 1-12.
172. Orth M, Schapira AH, (2001). Mitochondria degenerative disorders. Am J Med Genet 106: 27-36.
173. Pacher P, Hajnoczky G, (2001). Propagation of the apoptotic signal by mitochondrial waves. EMBO J 20: 4107-4121.
174. 2+ exchange. Proc Natl Acad Sci U S A 107: 436-441.
175. Parain K, Murer MG, Yan Q, Faucheux B, Agid Y, Hirsch E, et al. (1999). Reduced expression of BDNF protein in Parkinson's disease substantia nigra. Neuroreport 10: 557-561.
176. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi1 E, et al. (2011). Calcium signalling around mitochondria associated membranes (MAMs). Cell Commun Signal 9: 19.
177. Perera TD, Coplan JD, Lisanby SH, Lipira CM, Arif M, Carpio C, et al. (2007). Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates. J Neurosci 27: 4894-4901.
178. 2+ uptake. Nature 467: 291-296.
179. Peters A, Schweigerb U, Pellerine L, Hubolda C, Oltmannsb KM, et al. (2004). The selfish brain: competition for energy resources. Neurosci Biobehav Rev 28: 143-180.
180. Pieczenik SR, Neustadt J, (2007). Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83: 84-92.
181. 2+ homeostasis in the endoplasmic reticulum. Cell Death Differ 13: 1409-1418.
182. 2+ transfer in the control of apoptosis. Oncogene 27: 6407-6418.
183. Pittenger C, Duman RS, (2008). Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33: 88-109.
184. 2+ signalling in the Golgi apparatus. Cell Calcium 50: 184-192.
185. Plaisant F, Clippe A, Vander SD, Knoops B, Gressens P, (2003). Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice. Free Radic Biol Med 34: 862-872.
186. Platenik J, Kuramoto N, Yoneda Y, (2000). Molecular mechanisms associated with long-term consolidation of the NMDA signals. Life Sci 67: 335-364.
187. Poo MM, (2001). Neurotrophins as synaptic modulators. Nat Rev Neurosci 2: 24-32.
188. Qi H, Mailliet F, Spedding M, Rocher C, Zhang X, Delagrange P, et al. (2009). Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation. Neuropharmacology 56: 37-46.
189. Quiroz JA, Gray NA, Kato T, Manji HK, (2008). Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33: 2551-2565.
190. Rantamaki T, Hendolin P, Kankaanpaa A, Mijatovic J, Piepponen P, Domenici E, et al. (2004). Pharmacologically diverse antidepressants rapidly activate BDNF receptor TrkB and induce phospholipase-Cγ signaling pathways in mouse brain. Neuropsychopharmacology 32: 2152-2162.
191. Renton JP, Xu N, Clark JJ, Hansen MR, (2010). Interaction of neurotrophin signalling with Bcl-2 localized to the mitochondria and the endoplasmic reticulum on spiral ganglion neuron survival and neurite growth. J Neurosci Res 88: 2239-2251.
192. Rezin GT, Amboni G, Zugno AI, Quevedo J, Streck EL, (2009). Mitochondrial dysfunction and psychiatric disorders. Neurochem Res 34: 1021-1029.
193. Rezin GT, Cardoso MR, Goncalves CL, Scaini G, Fraga DB, Riegel RE, et al. (2008). Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem Int 53: 395-400.
194. Ricchelli F, Sileikyte J, Bernardi P, (2011). Shedding light on the mitochondrial permeability transition. Biochim Biophys Acta 1807: 482-490.
195. Richard D, Clavel S, Huang Q, Sanchis D, Ricquier D, (2001). Uncoupling protein 2 in the brain: distribution and function. Biochem Soc Trans 29: 812-817.
196. Rothman SM, Mattson MP, (2013). Activity-dependent, stress-responsive BDNF signalling and quest for optimal brain health and resilience throughout the lifespan. Neuroscience 239: 228-240.
197. Rusnak R, Mertz P, (2000). Calcineurin: form and function. Physiol Rev 80: 1483-1521.
198. Saha JB, Guilllily MD, Ferree A, Lanceta J, Chan D, Ghosh J, et al. (2009). LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci 29: 9210-9218.
199. Schinder AF, Poo M, (2000). The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 23: 639-645.
200. Schulz JB, Beal MF, (1994). Mitochondrial dysfunction in movement disorders. Curr Opin Neurol 7: 333-339.
201. Sherer TB, Betarbet R, Testa CM, Seo BB, Richardson JR, Kim JH, et al,. (2003). Mechanisms of toxicity in rotentone models of Parkinson's disease. J Neurosci 23: 10756-10764.
202. Shimizu E, Hashimoto K, Okanawa N, Kioke K, Komatsu N, Kumakiri C, et al. (2003). Alterations of serum levels of brain derived neurotrophic factor (BDNF) in depressed patients with or without antidepressant. Biol Psychiatry 54: 70-75.
203. Shoshan-Barmatz V, Ben-Hall D, (2012). VDAC, a multi-functional mitochondrial protein as a pharmacological target. Mitochondrion 12: 24-34.
204. Shoshan-Barmatz V, Keinan N, Zaid H, (2008). Uncovering the role of VDAC in the regulation of cell life and death. J Bioenerg Biomembr 40: 183-191.
205. Smith MA, Makino S, Kim SY, Kventnansky R, (1995). Stress increases BDNF messenger riboneucleic acid in the hypothalamus and pituitary. Endocrinology 136: 3743-3750.
206. Son TG, Camandola S, Mattson MP, (2008). Hormetic dietary phytochemicals. Neuromolecular Med 10: 236-246.
207. Spalletta G, Morris DW, Angelucci F, Rubino IA, Spoletini I, Bria P, et al. (2010). BDNF Val66Met polymorphism is associated with aggressive behaviour in schizophrenia. Eur Psychiatry 25: 311-313.
208. Spedding M, Gressens P, (2008). Neurotrophins and cytokines in neuronal plasticity. Novartis Found Symp 289: 222-233.
209. Spedding M, Spedding C, (2008). Drugs in sport: a scientist-athlete's perspective: from ambition to neurochemistry. Br J Pharmacol 154: 496-501.
210. Spedding M, Tillement JP, Morin D, Le Ridant A, (1999). Medicines interacting with mitochondria: anti-ischemic effects of trimetazidine. Therapie 54: 627-635.
211. Spencer JP, (2010). The impact of the fruit flavoniods on memory and cognition. Br J Nutr 104: 40-47.
212. Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, et al. (2004). Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci 24: 7779-7788.
213. Stranahan AM, Mattson MP, (2008). Impact of energy intake and expenditure on neuronal plasticity. Neuromolecular Med 10: 209-218.
214. Stranahan AM, Mattson MP, (2012). Recruiting adaptive cellular stress responses for successful brain ageing. Nat Rev Neurosci 13: 209-216.
215. Suen P, Wu K, Levine ES, Mount HT, Xu JL, Lin SY, et al. (1997). Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. Proc Natl Acad Sci U S A 94: 8191-8195.
216. Suri D, Vaidya VA, (2013). Glucocorticoids regulation of brain-derived neurotrophic factor: relevance to hippocampal structural and functional plasticity. Neuroscience 239: 196-213.
217. Suwanjang W, Holmstrom KM, Chetsawng B, Abramov AY, (2013). Glucocorticoids reduce intracellular calcium contration and protects neurons against glutamate toxicity. Cell Calcium 53: 256-263.
218. 2+ channels. J Cell Biol 175: 901-911.
219. Tagscherer KE, Fassl A, Campos B, Farhadi M, Kraemer A, Bock BC, et al. (2008). Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins. Oncogene 27: 6646-6656.
220. Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, et al. (2005). ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25: 5455-5463.
221. Teng KK, Felice S, Kim T, Hempstead BL, (2010). Understanding proneurotrophin actions: recent advances and challenges. Dev Neurobiol 70: 350-359.
222. Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, et al. (2012). Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS ONE 7: e32737.
223. Trushina E, Dutta T, Persson XM, Mielke MM, Petersen RC, (2013). Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS ONE 8: e63644.
224. Vaynman S, Ying Z, Gomez-Pinilla F, (2003). Interplay between BDNF and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience 122: 647-657.
225. Vaynman S, Ying Z, Wu A, Gomez-Pinilla F, (2006). Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity. Neuroscience 139: 1221-1234.
226. Vogel S, Keifer T, Raulf N, Sterz K, Manoharan A, Borner C, (2009). Mechanisms of Bax/Bak activation: is there any light at the end of the tunnel? Gastroenterol Hepatol 2: S11-S18.
227. Wallace DC, (2005). A mitochondrial paradigm of metabolic and degenerative diseases, aging and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39: 359-407.
228. Wallace DC, Shoffner JM, Trounce I, Brown MD, Ballinger SW, Corral-Debrinski M, et al. (1995). Mitochondrial DNA mutations in human degenerative diseases and aging. Biochim Biophys Acta 127: 141-151.
229. Wang GJ, Thayer SA, (2002). NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture. J Neurophysiol 87: 740-749.
230. Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X, (2009a). The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem 109: 153-159.
231. Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, et al. (2009b). Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29: 9090-9103.
232. + and NADH content. J Neurosci Res 89: 1956-1964.
233. Wong E, Cuervo AM, (2010). Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 31: 805-811.
234. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, et al. (2005). Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8: 1069-1077.
235. Wu A, Ying Z, Gomez-Pinilla F, (2004a). The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 19: 1699-1707.
236. Wu X, Zhu D, Jiang X, Okagaki Mearow K, Zhu G, McCall S, et al. (2004b). AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to up-regulate BDNF gene expression. J Neurochem 90: 807-818.
237. Xie H, Leung KL, Chen L, Chan YS, Ng PC, Fok TF, et al. (2010). Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity. Neurobiol Dis 40: 155-162.
238. Xu X, Zhan M, Duan W, Prabhu V, Brenneman R, Wood W, et al. (2007). Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol 8: R234.
239. Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA, (2010). Neuron s efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J Biol Chem 285: 28191-28199.
240. Youle RJ, Strasser A, (2008). The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59.
241. Young KW, Piñón LGP, Dhiraj D, Twiddy D, MacFarlane M, Hickman J, et al. (2010). Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-xL/Bcl-w antagonist ABT-737. Neuropharmacology 58: 1258-1267.
242. Yu L-Y, Saarma M, Arumae U, (2008). Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. J Neurosci 28: 7467-7475.
243. Yulug B, Ozan E, Gonul AS, Kilic E, (2009). Brain-derived neurotrophic factor, stress and depression: a minireview. Brain Res Bull 78: 267-269.
244. Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, (2001). Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293: 493-498.