Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells

Experimental Eye Research

Volumn 89, Issue 4, 2009, Pages 538-548

  Harper, Matthew M ^a,b,c,d   Adamson, Laura ^a,c   Blits, Bas ^e   Bunge, Mary Bartlett ^f   Grozdanic, Sinisa D ^a,d   Sakaguchi, Donald S ^a,b,c,d  

^a IOWA STATE UNIVERSITY   (United States)

^b Neuroscience Program   (United States)

^c Department of Genetics Development and Cell Biology   (United States)

^d Department of Biomedical Sciences ^*  (United States)

^e NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

BDNF; ganglion cells; glaucoma; mesenchymal stem cells; neuroprotection; RGC 5

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLUTAMIC ACID; GREEN FLUORESCENT PROTEIN; HYDROGEN PEROXIDE; LENTIVIRUS VECTOR; PROTEIN KINASE INHIBITOR; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; STAUROSPORINE; TRANSCRIPTION FACTOR POU4;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRESS; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; DNA MODIFICATION; IMMUNOREACTIVITY; MESENCHYMAL STEM CELL; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA GANGLION CELL; STAINING; TISSUE ENGINEERING;

ANIMALS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENETIC ENGINEERING; GLUTAMIC ACID; HYDROGEN PEROXIDE; MESENCHYMAL STEM CELLS; NEUROPROTECTIVE AGENTS; RATS; RECEPTOR, TRKB; RECOMBINANT PROTEINS; RETINAL GANGLION CELLS; STAUROSPORINE; TRANSCRIPTION FACTOR BRN-3A; TUBULIN;

EID: 69749118894     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.05.013     Document Type: Article

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