Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity

Cell Calcium

Volumn 53, Issue 4, 2013, Pages 256-263

  Suwanjang, Wilasinee ^a   Holmström, Kira M ^b   Chetsawang, Banthit ^a   Abramov, Andrey Y ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Queen Square ^*  (United Kingdom)

Author keywords

Astrocyte; Calcium; Corticosterone; Dexamethasone; Glucococorticoid; Glutamate; Neuron

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CALMODULIN; CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR ANTAGONIST; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL DEATH; CELL MEMBRANE; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; NERVE CELL; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 84875255430     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2012.12.006     Document Type: Article

References (29)

1. Barnes P. Glucocorticosteroids: current and future directions. British Journal of Pharmacology 2011, 163:29-43.
2. Kim M., Lee G., Jung E., Choi K., Oh G., Jeung E. Dexamethasone differentially regulates renal and duodenal calcium-processing genes in calbindin-D9k and D28k knockout mice. Experimental Physiology 2009, 94:138-151.
3. 2+ pumps. NeuroReport 2011, 22:660-663.
4. Reul J.M.H.M., Bosch J.R.V.d., de E.R.K. Relative occupation of type 1 and type 2 corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications. Journal of Endocrinology 1987, 115:459-467.
5. Beato M., Klug J. Steroid hormone receptors: an update. Human Reproduction Update 2000, 6:225-236.
6. Karst H., Nair S., Velzing E., Essen L., Slagter E., Shinnick-Gallagher P., Joels M. Glucocorticoids alter calcium conductance and calcium channel subunit expression in basolateral amygdala neurons. European Journal of Neuroscience 2002, 16:1083-1089.
7. Kawata M. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neuroscience Research 1995, 24:1-46.
8. Joels K.E.R.M., Holsboer F. Stress and the brain: from adaptation to disease. Nature Reviews Neuroscience 2005, 6:463-475.
9. Cole T. Glucocorticoid action and the development of selective glucocorticoid receptor ligands. Biotechnology Annual Review 2006, 12:269-300.
10. Seckl J. Glucocorticoid programming of the fetus: adult phenotypes and molecular mechanisms. Molecular and Cellular Endocrinology 2001, 185:61-71.
11. Young A., Sahakian B., Robbins T., Cowe P. The effects of chronic administration of hydrocortisone on cognitive function in normal volunteers. Psychopharmacology: The Third Generation of Progress, Raven Press, New York 1999, 145:260-266.
12. Lajic S., Nordenstrom A., Hirvikoski T. Long-term outcome of prenatal dexamethasone treatment of 21-hydroxylase deficiency. Endocrine Development 2011, 20:96-105.
13. Jia D., O'Brien C., Stewart S., Manolagas S., Weinstein R. Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology 2006, 147:5592-5599.
14. Stout A., Reynolds I. High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations. Neuroscience 1999, 89:91-100.
15. Abramov A., Duchen M. Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. Biochimica et Biophysica Acta 2010, 1800:297-304.
16. Menconi M., Gonnella P., Petkova V., Lecker S., Hasselgren P. Dexamethasone and corticosterone induced similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. Journal of Cellular Biochemistry 2008, 105:353-364.
17. Zhang Y., Sheng H., Qi J., Ma B., Sun J., Li S., Ni X. Glucocorticoid acts on a putative G protein-coupled receptor to rapidly regulate the activity of NMDA receptors in hippocampal neurons. American Journal of Physiology: Endocrinology and Metabolism 2012, 302:E747-E758.
18. Domijan A., Kovac S., Abramov A. Impact of fumonisin B1 on glutamate toxicity and low magnesium-induced seizure activity in neuronal primary culture. Neuroscience 2012, 202:10-16.
19. 2+ channels. Journal of Biological Chemistry 2005, 280:8776-8783.
20. Sasaki A., Matsubara A., Tabuchi K., Hara A., Namba A., Yamamoto Y., Shinkawa H. Immunoelectron microscopic analysis of neurotoxic effect of glutamate in the vestibular end organs during ischemia. Acta Otolaryngologica 2012, 132:686-692.
21. Abramov A., Duchen M. Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. Biochimica et Biophysica Acta 2008, 1777:953-964.
22. Vergun O., Keelan J., Khodorov B., Duchen M. Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurons. The Journal of Physiology 1999, 519:451-466.
23. Sukocheva O., Abramov A., Levitskaya J., Gagelgans A., Carpenter D. Modulation of intracellular Ca(2+) concentration by vitamin B12 in rat thymocytes. Blood Cells, Molecules, and Diseases 2001, 27:812-824.
24. Waring P., Beaver J. Cyclosporin A rescues thymocytes from apoptosis induced by very low concentration of thapsigargin: effect on mitochondrial function. Experimental Cell Research 1996, 227:264-276.
25. Carafoli E., Garcia-Martin E., Guerini D. The plasma membrane calcium pump: recent developments and future perspectives. Experientia 1996, 52:1091-1100.
26. Martens M., Peterson P., Lee C. In vitro effects of glucocorticoid on mitochondrial energy metabolism. Biochimica et Biophysica Acta 1991, 1058:152-160.
27. Morin C., Zini R., Simon N., Charbonnier P., Tillement J., Louet H.L. Low glucocorticoid concentrations decrease oxidative phosphorylation of isolated rat brain mitochondria: an additional effect of dexamethasone. Fundamental and Clinical Pharmacology 2000, 14:493-500.
28. Brown E.S. Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Annals of the New York Academy of Sciences 2009, 1179:41-55.
29. Domijan A., Abramov A. Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis-implication to mechanism of cell toxicity. International Journal of Biochemistry and Cell Biology 2011, 43:897-904.