Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

Nature Protocols

Volumn 9, Issue 4, 2014, Pages 967-976

  Rosati, Sara ^a,b   Yang, Yang ^a,b   Barendregt, Arjan ^a,b   Heck, Albert J R ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

ANTIBODY STRUCTURE; ARTICLE; CLINICAL PROTOCOL; CYCLIZATION; DEAMINATION; DRUG CONFORMATION; DRUG QUALITY; EXPERIMENTAL DESIGN; GLYCOSYLATION; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; MEASUREMENT ACCURACY; NATIVE MASS SPECTROMETRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN PROCESSING; QUALITATIVE ANALYSIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO; STRUCTURE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; PROCEDURES;

ANTIBODIES, MONOCLONAL; EQUIPMENT DESIGN; GLYCOSYLATION; MASS SPECTROMETRY; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84897142414     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2014.057     Document Type: Article

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