Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry

mAbs

Volumn 5, Issue 3, 2013, Pages 479-490

  Gahoual, Rabah ^a   Burr, Alicia ^a   Busnel, Jean Marc ^b   Kuhn, Lauriane ^a   Hammann, Phillipe ^a   Beck, Alain ^c   François, Yannis Nicolas ^a   Leize Wagner, Emmanuelle ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b BECKMAN COULTER INC   (United States)

^c INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

CESI MS MS; Mass spectrometry; Microheterogeneity; Microvariant; Monoclonal antibody; N linked glycosylation; Peptide mapping; Posttranslational modifications; Sheathless capillary electrophoresis

Indexed keywords

PEPTIDE FRAGMENT; TRASTUZUMAB; ISOPROTEIN; MONOCLONAL ANTIBODY;

ARTICLE; CAPILLARY ELECTROPHORESIS; DRUG STRUCTURE; HEAVY CHAIN; LIGHT CHAIN; PROTEIN ANALYSIS; PROTEOMICS; TANDEM MASS SPECTROMETRY; AMINO ACID SEQUENCE; GLYCOSYLATION; HUMAN; ISOLATION AND PURIFICATION; PEPTIDE MAPPING; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL, HUMANIZED; ELECTROPHORESIS, CAPILLARY; GLYCOSYLATION; HUMANS; PEPTIDE MAPPING; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOMICS; TANDEM MASS SPECTROMETRY;

EID: 84875490083     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.23995     Document Type: Article

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