Disulfide bond assignment of an IgG1 monoclonal antibody by LC-MS with post-column partial reduction

Analytical Biochemistry

Volumn 436, Issue 2, 2013, Pages 93-100

  Li, Xiaojuan ^a   Wang, Fengqiang ^a   Xu, Wei ^a   May, Kimberly ^a   Richardson, Daisy ^a   Liu, Hongcheng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Disulfide bonds; Mass spectrometry; Partial reduction

Indexed keywords

COVALENT BONDS; DATA HANDLING; INFORMATION ANALYSIS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; SULFUR COMPOUNDS;

ANALYSIS STRATEGIES; DISULFIDE BONDS; DISULFIDE LINKAGES; PARTIAL REDUCTION; POST-COLUMN; RECOMBINANT MONOCLONAL ANTIBODY;

REDUCTION;

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IGG1; UNCLASSIFIED DRUG;

ALGORITHM; ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DISULFIDE BOND; FEMALE; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING;

EID: 84874933070     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2013.01.020     Document Type: Article

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