In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

mAbs

Volumn 5, Issue 6, 2013, Pages 917-924

  Rosati, Sara ^a,b   Van Den Bremer, Ewald TJ ^c   Schuurman, Janine ^c   Parren, Paul Whi ^c   Kamerling, Johannis P ^a   Heck, Albert JR ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^c GENMAB   (Netherlands)

Author keywords

Antibody drug conjugates; Biopharmaceuticals; Biosimilars; Glycosylation; Monoclonal antibodies; Native mass spectrometry; Protein micro heterogeneity; Proteoforms

Indexed keywords

DRUG ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; MONOCLONAL ANTIBODY; PEPTIDE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G;

ANALYTICAL EQUIPMENT; ANTIBODY STRUCTURE; ARTICLE; DRUG CONJUGATION; MASS SPECTROMETRY; ORBITRAP EXACTIVE PLUS MASS SPECTROMETER; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN POLYMORPHISM; PROTEIN PROTEIN INTERACTION; QUALITATIVE ANALYSIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; CHEMISTRY; CLASSIFICATION; GENETICS; GLYCOSYLATION; SENSITIVITY AND SPECIFICITY;

ANTIBODIES, MONOCLONAL; GLYCOSYLATION; IMMUNOGLOBULIN G; MASS SPECTROMETRY; SENSITIVITY AND SPECIFICITY;

EID: 84889806552     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.26282     Document Type: Article

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