Native intact mass determination of antibodies conjugated with monomethyl Auristatin e and F at interchain cysteine residues

Analytical Chemistry

Volumn 84, Issue 6, 2012, Pages 2843-2849

  Valliere Douglass, John F ^a   McFee, William A ^a   Salas Solano, Oscar ^a  

^a SEATTLE GENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHIC CONDITIONS; CHROMATOGRAPHIC SEPARATIONS; CYSTEINE RESIDUES; DESOLVATION; DIRECT MEASUREMENT; DRUG-CONJUGATES; HEAVY CHAIN; LIGHT CHAIN; MASS DETERMINATION; MASS MEASUREMENTS; ONLINE MASS SPECTROMETRY; RAPID DETERMINATION;

AMINO ACIDS; CHROMATOGRAPHY; DESALINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ANTIBODIES;

ANTIBODY CONJUGATE; CYSTEINE; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MONOMETHYLAURISTATIN F; OLIGOPEPTIDE; RECOMBINANT PROTEIN; VEDOTIN;

ANIMAL; ARTICLE; CHEMISTRY; CHO CELL; HAMSTER; MASS SPECTROMETRY;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CYSTEINE; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; MASS SPECTROMETRY; OLIGOPEPTIDES; RECOMBINANT PROTEINS;

EID: 84858727362     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac203346c     Document Type: Article

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