Development and validation of a rapid capillary zone electrophoresis method for determining charge variants of mAb

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 906, Issue , 2012, Pages 63-68

  Shi, Ying ^a   Li, Zhen ^a   Qiao, Yuanbiao ^b   Lin, Jun ^c  

^a TAIYUAN NORMAL UNIVERSITY   (China)

^b Lvliang University   (China)

^c Analytical Sciences   (China)

Author keywords

Application; Capillary zone electrophoresis; Optimization; Therapeutic monoclonal antibody; Validation

Indexed keywords

ACETATE-ACETIC ACIDS; APPLIED VOLTAGES; BUFFER SYSTEM; CAPILLARY ZONE ELECTROPHORESIS; COADDITION; CORRELATION COEFFICIENT; HIGHER RESOLUTION; IDENTITY INFORMATION; ISOFORMS; MIGRATION TIME; PEAK RESOLUTION; THERAPEUTIC MONOCLONAL ANTIBODIES; TRIETHYLENETETRAMINE; VALIDATION; VALIDATION RESULTS;

ACETIC ACID; APPLICATIONS; MONOCLONAL ANTIBODIES; OPTIMIZATION; POLYETHYLENE OXIDES;

CAPILLARY ELECTROPHORESIS;

ACETIC ACID; BUFFER; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MACROGOL; MONOCLONAL ANTIBODY; TRIENTINE;

ACCURACY; ANTIBODY DETECTION; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CONTROLLED STUDY; DRUG DETERMINATION; PRIORITY JOURNAL; REPRODUCIBILITY; VALIDATION STUDY;

ANTIBODIES, MONOCLONAL; CARBOXYPEPTIDASE B; ELECTROPHORESIS, CAPILLARY; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN FRAGMENTS; PAPAIN; PROTEIN ISOFORMS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84866506945     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.08.022     Document Type: Article

References (20)

1. He Y., Isele C., Hou W., Ruesch M. J. Sep. Sci. 2011, 34:548.
2. Seo J., Lee K.J. J. Biochem. Mol. Biol. 2004, 37:35.
3. Mann M., Jensen O.N. Nat. Biotechnol. 2003, 21:255.
4. Wenisch E., Reiter S., Hinger S., Steindl F., Tauer C., Jungbauer A., Katinger H., Righetti P.G. Electrophoresis 1990, 11:966.
5. Stephenson R.C., Clarke S. J. Biol. Chem. 1989, 264:6164.
6. Chirino A.J., Mire-Sluis A. Nat. Biotechnol. 2004, 22:1383.
7. Dick L.W., Qiu D., Mahon D., Adamo M., Cheng K.C. Biotechnol. Bioeng. 2008, 100:1132.
8. Maeda E., Urakami K., Shimura K., Kinoshita M., Kakehi K. J. Chromatogr A. 2010, 1217:7164.
9. Jefferis R., Lund J. Immunol. Lett. 2002, 82:57.
10. Harris R.J. Dev. Biol. (Basel) 2005, 122:117.
11. Liu H., Gaza-Bulseco G., Xiang T., Chumsae C. Mol. Immunol. 2008, 45:701.
12. Liu D., Ren D., Huang H., Dankberg J., Rosenfeld R., Cocco M.J., Li L., Brems D.N., Remmele R.L. Biochemistry 2008, 47:5088.
13. Houde D., Peng Y., Berkowitz S.A., Engen J.R. Mol. Cell Proteomics 2010, 9(8):1716.
14. Lin J., Tan Q.Q., Wang S.X. J. Sep. Sci. 2011, 34:1696.
15. Tang S., Nesta D.P., Maneri L.R., Anumula K.R. J. Pharm. Biomed. Anal. 1999, 19:569.
16. Sosic Z., Houde D., Blum A., Carlage T., Lyubarskaya Y. Electrophoresis 2008, 29:4368.
17. He X.Z., Que A.H., Mo J.J. Electrophoresis 2009, 30:714.
18. Dai H.J., Li G., Krull I.S. J. Pharm. Biomed. Anal. 1998, 17:1143.
19. Ma S., Nashabeh W. Chromatographia 2001, 53:S75.
20. He Y., Lacher N.A., Hou W., Wang Q., Isele C., Starkey J., Ruesch M. Anal. Chem. 2010, 82:3222.