Disulfide bond structures of IgG molecules: Structural variations, chemical modifications and possible impacts to stability and biological function

mAbs

Volumn 4, Issue 1, 2012, Pages 17-23

  Liu, Hongcheng ^a   May, Kimberly ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aggregation; Dehydroalanine; Disulfide bond; Free sulfhydryl; Recombinant monoclonal antibody; Thioether; Trisulfide bond

Indexed keywords

CYSTEINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; THIOL DERIVATIVE;

CHEMICAL MODIFICATION; DISULFIDE BOND; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW;

ANTIBODIES, MONOCLONAL; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; PROTEIN ISOFORMS; RECOMBINANT PROTEINS;

EID: 84863045993     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.4.1.18347     Document Type: Review

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