Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: Characterization of immune complexes using noncovalent ESI-MS

Analytical Chemistry

Volumn 81, Issue 15, 2009, Pages 6364-6373

  Atmanene, Cédric ^a   Wagner Rousset, Elsa ^b   Malissard, Martine ^b   Chol, Bertrand ^b   Robert, Alain ^b   Corvaïa, Nathalie ^b   Van Dorsselaer, Alain ^a   Beck, Alain ^b   Sanglier Cianférani, Sarah ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AG COMPLEX; AMINO ACID SEQUENCE; ANALYTICAL TECHNIQUES; DISULFIDE BRIDGE; IMMUNE COMPLEX; ION MOBILITY; LARGE BIOMOLECULES; LEAD OPTIMIZATION; MONOCLONAL ANTIBODIES (MABS); NANOELECTROSPRAY; NATIVE STRUCTURES; NONCOVALENT; POST-TRANSLATIONAL MODIFICATIONS; RECOGNITION PROPERTIES; STRUCTURAL FEATURE; STRUCTURAL INSIGHTS; THERAPEUTIC MONOCLONAL ANTIBODIES; TRAVELING WAVE; TUMOR CELLS;

ALLERGIES; AMINES; AMINO ACIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; SURFACE PLASMON RESONANCE;

ANTIGENS;

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6F4; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOMATION; BINDING AFFINITY; COMPLEX FORMATION; DISULFIDE BOND; ELECTROSPRAY MASS SPECTROMETRY; GENE OVEREXPRESSION; MASS SPECTROMETRY; PROTEIN PROCESSING; RELIABILITY; TECHNOLOGY; TUMOR CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; CELL ADHESION MOLECULES; DISULFIDES; HUMANS; IMMUNOGLOBULINS; MICE; PEPTIDE FRAGMENTS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 68049103219     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9007557     Document Type: Article

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