Exploring an orbitrap analyzer for the characterization of intact antibodies by native mass spectrometry

Angewandte Chemie - International Edition

Volumn 51, Issue 52, 2012, Pages 12992-12996

  Rosati, Sara ^a   Rose, Rebecca J ^a   Thompson, Natalie J ^a   Van Duijn, Esther ^a   Damoc, Eugen ^b   Denisov, Eduard ^b   Makarov, Alexander ^b   Heck, Albert J R ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b THERMO FISHER SCIENTIFIC   (Germany)

Author keywords

Analytical methods; Antibodies; Biopharmaceuticals; Native mass spectrometry; Orbitrap

Indexed keywords

ANALYTICAL METHOD; ANALYTICAL TOOL; ANTIBODY DRUGS; BIOPHARMACEUTICAL INDUSTRY; BIOPHARMACEUTICALS; CLINICAL USE; DISULFIDE BONDS; HEAVY CHAIN; HIGH SPECIFICITY; IMMUNOGLOBULIN G; LIGHT CHAIN; MONOCLONAL ANTIBODIES (MABS); ORBITRAP;

ANTIBODIES; COVALENT BONDS; MOLECULES; MONOCLONAL ANTIBODIES;

MASS SPECTROMETRY;

ANTIGEN; INTERLEUKIN 6; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL STRAIN HEK293; CHEMISTRY; GENETICS; GLYCOSYLATION; HUMAN; IMMUNOLOGY; MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; ANTIGENS; GLYCOSYLATION; HEK293 CELLS; HUMANS; INTERLEUKIN-6; MASS SPECTROMETRY; RECOMBINANT PROTEINS;

EID: 84871270725     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201206745     Document Type: Article

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