Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch

Journal of Biological Chemistry

Volumn 289, Issue 12, 2014, Pages 8484-8492

  Loo, Tip W ^a   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; COMPUTER SIMULATION; GLYCOPROTEINS; MOLECULAR DYNAMICS;

ATP-BINDING CASSETTE; CAENORHABDITIS ELEGANS; HIGH-RESOLUTION STRUCTURES; MOLECULAR DYNAMICS SIMULATIONS; MULTIDRUG RESISTANCE; NUCLEOTIDE-BINDING DOMAIN; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE SEGMENTS;

BIOLOGICAL MEMBRANES;

ADENOSINE TRIPHOSPHATASE; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; MUTATION RATE; PREDICTION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; RESIDUE ANALYSIS; STRUCTURE ANALYSIS;

ABC TRANSPORTER; DRUG RESISTANCE; MEMBRANE ENZYMES; MEMBRANE PROTEINS; PROTEIN CROSS-LINKING;

ADENOSINE TRIPHOSPHATE; ANIMALS; CROSS-LINKING REAGENTS; HUMANS; MICE; MODELS, MOLECULAR; P-GLYCOPROTEIN; POINT MUTATION; PROTEIN CONFORMATION;

EID: 84897005223     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.552075     Document Type: Article

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