Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: Implications for catalysis

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7575-7586

  Siarheyeva, Alena ^a   Liu, Ronghua ^a   Sharom, Frances J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AFFINITY STATE; ATP BINDING; ATP HYDROLYSIS; BINDING AFFINITIES; BOUND MOLECULES; CATALYTIC CYCLES; COLLISIONAL QUENCHING; COVALENT LABELING; CYS RESIDUES; HIGH AFFINITY; MODE OF ACTION; MULTIDRUG EFFLUX; NUCLEOTIDE BINDING; NUCLEOTIDE-BINDING DOMAIN; P-GLYCOPROTEIN; TRIPHOSPHATE;

BINDING ENERGY; BINDING SITES; HYDROLYSIS; NUCLEOTIDES; OLIGOMERS;

GLYCOPROTEINS;

ADENOSINE TRIPHOSPHATE; CYSTEINE; DAUNORUBICIN; GLYCOPROTEIN P; NUCLEOTIDE DERIVATIVE; PROPAFENONE; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; ASYMMETRIC CATALYSIS; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; HYDROLYSIS; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; AFFINITY LABELS; ANILINO NAPHTHALENESULFONATES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; CATALYSIS; CRICETINAE; CRICETULUS; DAUNORUBICIN; HUMANS; MICE; NUCLEOTIDES; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TUBULIN MODULATORS; VANADATES; VINBLASTINE;

EID: 77951241376     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.047290     Document Type: Article

References (63)

1. Dassa, E., and Bouige, P. (2001) Res. Microbiol. 152, 211-229
2. Dean, M., Rzhetsky, A., and Allikmets, R. (2001) Genome Res. 11, 1156-1166
3. Davidson, A. L., Dassa, E., Orelle, C., and Chen, J. (2008) Microbiol. Mol. Biol. Rev. 72, 317-364
4. Linton, K. J. (2007) Physiology 22, 122-130
5. Sharom, F. J. (2007) in Drug Transporters: Molecular Characterization and Role in Drug Disposition (You, G., and Morris, M. E., eds) pp. 223-262, John Wiley & Sons, Inc., Hoboken, NJ
6. Zhou, S. F. (2008) Xenobiotica 38, 802-832
7. Eckford, P. D., and Sharom, F. J. (2009) Chem. Rev. 109, 2989-3011
8. Urbatsch, I. L., Sankaran, B., Bhagat, S., and Senior, A. E. (1995) J. Biol. Chem. 270, 26956-26961
9. Urbatsch, I. L., Sankaran, B., Weber, J., and Senior, A. E. (1995) J. Biol. Chem. 270, 19383-19390
10. Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1995) FEBS Lett. 377, 285-289
11. Senior, A. E. (1998) Acta Physiol. Scand. Suppl. 643, 213-218
12. Sauna, Z. E., and Ambudkar, S. V. (2007) Mol. Cancer Ther. 6, 13-23
13. Callaghan, R., Ford, R. C., and Kerr, I. D. (2006) FEBS Lett. 580, 1056-1063
14. Smith, P. C., Karpowich, N., Millen, L., Moody, J. E., Rosen, J., Thomas, P. J., and Hunt, J. F. (2002) Mol. Cell 10, 139-149
15. Hopfner, K. P., Karcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., and Tainer, J. A. (2000) Cell 101, 789-800
16. Zaitseva, J., Jenewein, S., Jumpertz, T., Holland, I. B., and Schmitt, L. (2005) EMBO J. 24, 1901-1910
17. Dawson, R. J., and Locher, K. P. (2007) FEBS Lett. 581, 935-938
18. Oldham, M. L., Khare, D., Quiocho, F. A., Davidson, A. L., and Chen, J. (2007) Nature 450, 515-521
19. Jones, P. M., and George, A. M. (1999) FEMS Microbiol. Lett. 179, 187-202
20. Zaitseva, J., Oswald, C., Jumpertz, T., Jenewein, S., Wiedenmann, A., Holland, I. B., and Schmitt, L. (2006) EMBO J. 25, 3432-3443
21. Zaitseva, J., Jenewein, S., Oswald, C., Jumpertz, T., Holland, I. B., and Schmitt, L. (2005) Biochem. Soc. Trans. 33, 990-995
22. Lu, G., Westbrooks, J. M., Davidson, A. L., and Chen, J. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 17969-17974
23. Oloo, E. O., Fung, E. Y., and Tieleman, D. P. (2006) J. Biol. Chem. 281, 28397-28407
24. Oswald, C., Holland, I. B., and Schmitt, L. (2006) Naunyn Schmiedebergs Arch. Pharmacol. 372, 385-399
25. Tombline, G., and Senior, A. E. (2005) J. Bioenerg. Biomembr. 37, 497-500
26. Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P. M., Trinh, Y. T., Zhang, Q., Urbatsch, I. L., and Chang, G. (2009) Science 323, 1718-1722
27. Sauna, Z. E.,Müller, M., Peng, X. H., and Ambudkar, S. V. (2002) Biochemistry 41, 13989-14000
28. Tombline, G., Bartholomew, L. A., Urbatsch, I. L., and Senior, A. E. (2004) J. Biol. Chem. 279, 31212-31220
29. Tombline, G., Muharemagić, A., White, L. B., and Senior, A. E. (2005) Biochemistry 44, 12879-12886
30. Sauna, Z. E., Kim, I. W., Nandigama, K., Kopp, S., Chiba, P., and Ambudkar, S. V. (2007) Biochemistry 46, 13787-13799
31. Tmej, C., Chiba, P., Huber, M., Richter, E., Hitzler, M., Schaper, K. J., and Ecker, G. (1998) Arch. Pharm. 331, 233-240
32. Liu, R., and Sharom, F. J. (1996) Biochemistry 35, 11865-11873
33. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
34. Peterson, G. L. (1977) Anal. Biochem. 83, 346-356
35. Qu, Q., Russell, P. L., and Sharom, F. J. (2003) Biochemistry 42, 1170-1177
36. Russell, P. L., and Sharom, F. J. (2006) Biochem. J. 399, 315-323
37. Sharom, F. J., Yu, X., Chu, J. W., and Doige, C. A. (1995) Biochem. J. 308, 381-390
38. Bronnikov, G. E., and Zakharov, S. D. (1983) Anal. Biochem. 131, 69-74
39. Romsicki, Y., and Sharom, F. J. (1999) Biochemistry 38, 6887-6896
40. Lakowicz, J. R. (2006) Principles of Fluorescence Spectroscopy, 3rd Ed., Springer Science+ Business Media, New York
41. Quay, S. C., Heropoulos, A., Commes, K., and Dzau, V. J. (1985) J. Biol. Chem. 260, 15055-15058
42. Lugo, M. R., and Sharom, F. J. (2009) Arch. Biochem. Biophys. 492, 17-28
43. Liu, R., Siemiarczuk, A., and Sharom, F. J. (2000) Biochemistry 39, 14927-14938
44. Sharom, F. J., Liu, R., Romsicki, Y., and Lu, P. (1999) Biochim. Biophys. Acta 1461, 327-345
45. Schuurmans Stekhoven, F. M., Swarts, H. G., Fu, Y. F., Kuijpers, G. A., De Pont, J. J., and Bonting, S. L. (1984) Biochim. Biophys. Acta 774, 277-287
46. Yasuoka, K., Kawakita, M., and Kaziro, Y. (1982) J. Biochem. 91, 1629-1637
47. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 22957-22961
48. Sauna, Z. E., Nandigama, K., and Ambudkar, S. V. (2006) J. Biol. Chem. 281, 26501-26511
49. Urbatsch, I. L., al-Shawi, M. K., and Senior, A. E. (1994) Biochemistry 33, 7069-7076
50. Martin, C., Berridge, G., Mistry, P., Higgins, C., Charlton, P., and Callaghan, R. (2000) Biochemistry 39, 11901-11906
51. al-Shawi, M. K., and Senior, A. E. (1993) J. Biol. Chem. 268, 4197-4206
52. al-Shawi, M. K., Urbatsch, I. L., and Senior, A. E. (1994) J. Biol. Chem. 269, 8986-8992
53. Verdon, G., Albers, S. V., van Oosterwijk, N., Dijkstra, B. W., Driessen, A. J., and Thunnissen, A. M. (2003) J. Mol. Biol. 334, 255-267
54. Hou, Y. X., Cui, L., Riordan, J. R., and Chang, X. B. (2002) J. Biol. Chem. 277, 5110-5119
55. Payen, L., Gao, M., Westlake, C., Theis, A., Cole, S. P., and Deeley, R. G. (2005) Mol. Pharmacol. 67, 1944-1953
56. Ramachandra, M., Ambudkar, S. V., Chen, D., Hrycyna, C. A., Dey, S., Gottesman, M. M., and Pastan, I. (1998) Biochemistry 37, 5010-5019
57. Qu, Q., Chu, J. W., and Sharom, F. J. (2003) Biochemistry 42, 1345-1353
58. Neumann, L., Abele, R., and Tampé, R. (2002) J. Mol. Biol. 324, 965-973
59. Chen, M., Abele, R., and Tampé, R. (2003) J. Biol. Chem. 278, 29686-29692
60. Higgins, C. F., and Linton, K. J. (2004) Nat. Struct. Mol. Biol. 11, 918-926
61. Janas, E., Hofacker, M., Chen, M., Gompf, S., van der Does, C., and Tampé, R. (2003) J. Biol. Chem. 278, 26862-26869
62. Pretz, M. G., Albers, S. V., Schuurman-Wolters, G., Tampé, R., Driessen, A. J., and van der Does, C. (2006) Biochemistry 45, 15056-15067
63. Delannoy, S., Urbatsch, I. L., Tombline, G., Senior, A. E., and Vogel, P. D. (2005) Biochemistry 44, 14010-14019