Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

Biochemical Journal

Volumn 396, Issue 3, 2006, Pages 537-545

  Loo, Tip W ^a   Bartlett, M Claire ^a   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cysteine scanning mutagenesis; Drug transport; Drug binding pocket; P glycoprotein; Protein modification; Transmembrane segment 1 (TM1)

Indexed keywords

ADENOSINETRIPHOSPHATE; CELLS; DRUG PRODUCTS; HYDROLYSIS; MUTAGENESIS; SUBSTRATES;

CYSTEINE-SCANNING MUTAGENESIS; DRUG TRANSPORT; DRUG-BINDING POCKET; P-GLYCOPROTEIN; PROTEIN MODIFICATION; TRANSMEMBRANE SEGMENT 1 (TM1);

PROTEINS;

ADENOSINE TRIPHOSPHATASE; DITHIOTHREITOL; GLYCOPROTEIN P; VERAPAMIL; CALCEIN AM; COLCHICINE; CYCLOSPORIN; DEMECOLCINE; DISULFIDE; DRUG DERIVATIVE; FLUORESCEIN DERIVATIVE; FLUPENTIXOL; MESYLIC ACID DERIVATIVE; METHANETHIOSULFONATE; VINBLASTINE;

ARTICLE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROLYSIS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CELL LINE; DRUG EFFECT; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; POINT MUTATION; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL LINE; COLCHICINE; CRICETINAE; CYCLOSPORINE; DEMECOLCINE; DISULFIDES; DITHIOTHREITOL; FLUORESCEINS; FLUPENTHIXOL; HUMANS; MESYLATES; P-GLYCOPROTEIN; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; VERAPAMIL; VINBLASTINE;

EID: 33745008903     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060012     Document Type: Article

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