Catalytic transitions in the human mdr1 P-glycoprotein drug binding sites

Biochemistry

Volumn 51, Issue 25, 2012, Pages 5125-5141

  Wise, John G ^a  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP HYDROLYSIS; ATP-BINDING CASSETTE; CATALYTIC MECHANISMS; DRUG BINDING; DYNAMICS SIMULATION; EXTRACELLULAR; EXTRACELLULAR SPACE; MULTIDRUG RESISTANCE; NUCLEOTIDE-BINDING DOMAIN; P-GLYCOPROTEIN; PROTEIN STRUCTURES; STRUCTURE ANALYSIS; TARGETED MOLECULAR DYNAMICS; TRANS-MEMBRANE DOMAINS; TRANSITION STATE;

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; BODY FLUIDS; CHEMOTHERAPY; CYTOLOGY; GLYCOPROTEINS; HYDROLYSIS; LIGANDS; MOLECULAR DYNAMICS;

BINDING SITES;

GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EXTRACELLULAR SPACE; HUMAN; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIMULATION; VALIDATION STUDY;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84862890003     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300299z     Document Type: Article

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