Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 229-236

  Loo, Tip W ^a   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; GLYCOPROTEINS; HYDROPHOBICITY; SIGNAL TRANSDUCTION;

ATP-ASE ACTIVITY; BALL AND SOCKETS; DITHIOTHREITOL; HYDROPHOBIC POCKETS; HYDROPHOBIC RESIDUES; NUCLEOTIDE-BINDING DOMAIN; TRANS-MEMBRANE DOMAINS; TRANSMISSION INTERFACES;

ENZYME ACTIVITY;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; CYSTEINE; DITHIOTHREITOL; MULTIDRUG RESISTANCE PROTEIN; PHENYLALANINE; TRYPTOPHAN; VERAPAMIL; ABCB1 PROTEIN, HUMAN; CROSS LINKING REAGENT;

ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; CROSS LINKING; DNA FLANKING REGION; ENZYME ACTIVATION; HYDROPHOBICITY; INHIBITION KINETICS; INTRACELLULAR LOOP; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; RESIDUE ANALYSIS; AMINO ACID SUBSTITUTION; ANALOGS AND DERIVATIVES; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CROSS-LINKING REAGENTS; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84891675817     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.527804     Document Type: Article

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