Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism

Biochemistry

Volumn 42, Issue 5, 2003, Pages 1345-1353

  Qu, Qin ^a   Chu, Joseph W K ^a   Sharom, Frances J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MULTIDRUG TRANSPORTERS;

FLUORESCENCE; HYDROPHOBICITY; POLYPEPTIDES; PROTEINS; SPECTROSCOPIC ANALYSIS; SUBSTRATES;

DRUG PRODUCTS;

ADENOSINE DIPHOSPHATE; COBALT; COLCHICINE; CYCLOSPORIN A; DOXORUBICIN; DRUG DERIVATIVE; GLYCOPROTEIN P; HOE 33342; MAGNESIUM; METAL ION; NATURAL PRODUCT; PEPTIDE; RHODAMINE 123; VANADIC ACID; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CATALYSIS; CELL TRANSPORT; CONTROLLED STUDY; CYTOPLASM; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG RELEASE; DRUG TRANSPORT; HYDROPHOBICITY; MATHEMATICAL ANALYSIS; MEMBRANE TRANSPORT; METAL BINDING; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ISOLATION; PROTEIN PURIFICATION; SPECTROFLUOROMETRY; TRANSPORT KINETICS;

ADENOSINE DIPHOSPHATE; ANILINO NAPHTHALENESULFONATES; ANIMALS; AZIDES; BENZIMIDAZOLES; BIOLOGICAL TRANSPORT; CHO CELLS; COBALT; CRICETINAE; DIHYDROPYRIDINES; DOXORUBICIN; MAGNESIUM; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PHOTOAFFINITY LABELS; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN; VANADATES; VINBLASTINE;

ANIMALIA;

EID: 0037432013     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0267745     Document Type: Article

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