Cross-linking of human multidrug resistance P-glycoprotein by the substrate, Tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis: Evidence for rotation of a transmembrane helix

Journal of Biological Chemistry

Volumn 276, Issue 34, 2001, Pages 31800-31805

  Loo, Tip W ^b   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINES; BIOLOGICAL MEMBRANES; CROSSLINKING; ELECTROPHORESIS; ENZYME INHIBITION; HYDROLYSIS; ROTATION;

TRANSMEMBRANE HELIX;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; COLCHICINE; CYCLOSPORIN A; GLYCOPROTEIN P; MALEIMIDE DERIVATIVE; TRIS(2 MALEIMIDOETHYL)AMINE; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE; CROSS LINKING REAGENT; TRIS(2-MALEIMIDOETHYL)AMINE; VANADIC ACID;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CROSS LINKING; DRUG BINDING; DRUG BINDING SITE; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HYDROLYSIS; MULTIDRUG RESISTANCE; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; CELL LINE; CROSS-LINKING REAGENTS; HUMANS; HYDROLYSIS; MALEIMIDES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; P-GLYCOPROTEIN; SUBSTRATE SPECIFICITY; VANADATES;

EID: 0035943691     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103498200     Document Type: Article

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