Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20326-20333

  Loo, Tip W ^a   Bartlett, M Claire ^a   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RESIDUES; ATP-ASE ACTIVITY; BALL AND SOCKETS; CONFORMATIONAL CHANGE; NUCLEOTIDE-BINDING DOMAIN; TRANSMEMBRANE DOMAIN; TRANSMISSION INTERFACES; TRANSPORT MECHANISM;

AMINO ACIDS; GLYCOPROTEINS; HYDROPHOBICITY; SIGNAL TRANSDUCTION;

ENZYME ACTIVITY;

ADENOSINE TRIPHOSPHATASE; ALANINE; ALANINE 266; CYCLOSPORIN A; CYSTEINE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; NUCLEOTIDE BINDING PROTEIN; PHENYLALANINE; PHENYLALANINE 1086; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HYDROLYSIS; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN;

ABC TRANSPORTER; ATPASES; MEMBRANE PROTEINS; MEMBRANE TRAFFICKING; PROTEIN FOLDING;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CELL MEMBRANE; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; P-GLYCOPROTEIN; PHENANTHROLINES; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; VANADATES;

EID: 84880054199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.484550     Document Type: Article

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