On the origin of large flexibility of P-glycoprotein in the inward-facing state

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19211-19220

  Wen, Po Chao ^a   Verhalen, Brandy ^b   Wilkens, Stephan ^c   Mchaourab, Hassane S ^b   Tajkhorshid, Emad ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGREE OF SEPARATION; DOUBLE ELECTRON-ELECTRON RESONANCE; EQUILIBRIUM SIMULATIONS; MOLECULAR DYNAMICS SIMULATIONS; MULTIDRUG RESISTANCE; NUCLEOTIDE-BINDING DOMAIN; STRUCTURAL FLEXIBILITIES; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; MOLECULAR DYNAMICS; STRUCTURAL DYNAMICS;

GLYCOPROTEINS;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; AMINO ACID; MULTIDRUG RESISTANCE PROTEIN;

AMINO ACID COMPOSITION; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; MOLECULAR DYNAMICS; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SEQUENCE ANALYSIS;

ABC TRANSPORTER; DOUBLE ELECTRON ELECTRON RESONANCE SPECTROSCOPY (DEER); ELECTRON PARAMAGNETIC RESONANCE (EPR); MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; P-GLYCOPROTEIN; PROTEIN DYNAMICS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIPIDS; MICE; MOLECULAR DYNAMICS SIMULATION; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 84879576243     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.450114     Document Type: Article

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