Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: Evidence for simultaneous binding of both drugs

Biochemistry

Volumn 44, Issue 42, 2005, Pages 14020-14029

  Lugo, Miguel R ^b   Sharom, Frances J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b FACULTAD DE CIENCIAS   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; DRUG PRODUCTS; FLUORESCENCE; HYDROLYSIS; HYDROPHOBICITY; SUBSTRATES;

CYTOPLASMIC LEAFLET; FLUORESCENCE TITRATIONS; HYDROPHOBIC DRUGS;

PROTEINS;

2 [4 [4 (DIMETHYLAMINO)PHENYL] 1,3 BUTADIENYL] 3 ETHYLBENZOTHIAZOLIUM PERCHLORATE; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; AMINE; BENZENE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; GLYCOPROTEIN P; HOE 33342; LDS 751; NATURAL PRODUCT; PEPTIDE DERIVATIVE; RHODAMINE 123; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CYTOPLASM; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENERGY; HYDROLYSIS; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN FAMILY; TITRIMETRY;

ANIMALS; CHO CELLS; CRICETINAE; FLUORESCENT DYES; ORGANIC CHEMICALS; P-GLYCOPROTEIN; PROTEIN BINDING; RHODAMINE 123; SPECTROMETRY, FLUORESCENCE;

EID: 27144451192     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0511179     Document Type: Article

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