Applying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure

Prion

Volumn 8, Issue 1, 2014, Pages

  Silva, Christopher J ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Covalent modification; Lysine; Mass spectrometry; Monoclonal antibody; Prion; Western blot

Indexed keywords

AMINO ACID; ASPARAGINE; DISULFIDE; EPITOPE; LYSINE; METHIONINE; POLYMER; PRION PROTEIN; PROTEINASE K; REAGENT;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; CHEMICAL MODIFICATION; COVALENT MODIFICATION; DISULFIDE BOND; HUMAN; MASS SPECTROMETRY; NONHUMAN; PARKINSON DISEASE; PRION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; QUANTITATIVE ANALYSIS; REVIEW; WESTERN BLOTTING; WILD TYPE; ANIMAL; CHEMISTRY; HAMSTER; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; PROTEOSTASIS DEFICIENCY;

AMINO ACID SEQUENCE; ANIMALS; CRICETINAE; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEOSTASIS DEFICIENCIES; PRPC PROTEINS; PRPSC PROTEINS;

EID: 84896906381     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.27891     Document Type: Review

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