Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28263-28275

  Younan, Nadine D ^a   Nadal, Rebecca C ^a   Davies, Paul ^b   Brown, David R ^b   Viles, John H ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID FIBERS; HELICAL CONTENT; HYDROPHOBIC RESIDUES; METHIONINE OXIDATION; MISFOLDING; MOLTEN GLOBULE; NMR STUDIES; PRION DISEASE; PRION PROTEIN; STRAND STRUCTURE; STRUCTURAL CORE; TERNARY STRUCTURE; THERMODYNAMIC EXPLANATION;

AMINO ACIDS; CATALYSIS; COPPER; HYDROPHOBICITY; NEURODEGENERATIVE DISEASES; PROTEINS; UREA;

OXIDATION;

HISTIDINE; METHIONINE; PRION PROTEIN;

ARTICLE; CONTROLLED STUDY; HYDROPHOBICITY; NONHUMAN; OXIDATIVE STRESS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN MISFOLDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; STRUCTURE ANALYSIS; THERMODYNAMICS; THERMOSTABILITY;

AMYLOID; ANIMALS; HYDROGEN PEROXIDE; METHIONINE; MICE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; PRIONS; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; UREA;

EID: 84865234351     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.354779     Document Type: Article

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