PK-sensitive PrPSc is infectious and shares basic structural features with PK-resistant PrPSc

PLoS Pathogens

Volumn 8, Issue 3, 2012, Pages

  Sajnani, Gustavo ^a,e   Silva, Christopher J ^b   Ramos, Adriana ^a   Pastrana, Miguel A ^a   Onisko, Bruce C ^b,f   Erickson, Melissa L ^b   Antaki, Elizabeth M ^b,c   Dynin, Irina ^b   Vázquez Fernández, Ester ^a   Sigurdson, Christina J ^c,d   Carter, J Mark ^b   Requena, Jesús R ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b WESTERN REGIONAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e National Paraplegia Hospital   (Spain)

^f OniPro   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMER; PRION PROTEIN; PROTEINASE K; RESISTANT PROTEIN PRP SC; SENSITIVE PROTEIN PRP SC; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; FEMALE; INCUBATION TIME; INFECTION; INOCULATION; MASS SPECTROMETRY; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN STRUCTURE; STRAIN DIFFERENCE; ANIMAL; BRAIN; COMPARATIVE STUDY; DISEASE MODEL; ENZYMOLOGY; HAMSTER; LONGEVITY; METABOLISM; PATHOLOGY; PROTEIN CONFORMATION; R FACTOR; SCRAPIE; SYRIAN HAMSTER;

CRICETINAE;

ANIMALS; BRAIN; CRICETINAE; DISEASE MODELS, ANIMAL; ENDOPEPTIDASE K; LONGEVITY; MESOCRICETUS; PROTEIN CONFORMATION; PRPSC PROTEINS; R FACTORS; SCRAPIE;

EID: 84861209811     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002547     Document Type: Article

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