Using isotopically-coded hydrogen peroxide as a surface modification reagent for the structural characterization of prion protein aggregates

Journal of Proteomics

Volumn 100, Issue , 2014, Pages 160-166

  Serpa, Jason J ^a   Makepeace, Karl A T ^a   Borchers, Tristan H ^a   Wishart, David S ^b   Petrotchenko, Evgeniy V ^a   Borchers, Christoph H ^a,c  

^a UNIVERSITY OF VICTORIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Chemical surface modification; Mass spectrometry; Oxidative labeling; Prion aggregate structure; Stable isotope labeled hydrogen peroxide; Structural proteomics

Indexed keywords

BETA OLIGOMERIC PRION PROTEIN; FIBRIL PRION PROTEIN; HYDROGEN PEROXIDE; METHIONINE; PRION PROTEIN; REAGENT; TRYPTOPHAN; UNCLASSIFIED DRUG; OXYGEN; PRION;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SURFACE PROPERTY; CHEMISTRY; ISOTOPE LABELING; PRION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE;

HYDROGEN PEROXIDE; ISOTOPE LABELING; METHIONINE; OXYGEN; OXYGEN ISOTOPES; PRIONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PRPC PROTEINS; PRPSC PROTEINS; TRYPTOPHAN;

EID: 84897038817     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2013.11.020     Document Type: Article

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