Biophysical properties and cellular toxicity of covalent crosslinked oligomers of α-synuclein formed by photoinduced side-chain tyrosyl radicals

Free Radical Biology and Medicine

Volumn 53, Issue 4, 2012, Pages 1004-1015

  Borsarelli, Claudio D ^a,b   Falomir Lockhart, Lisandro J ^b   Ostatná, Veronika ^c   Fauerbach, Jonathan A ^d   Hsiao, He Hsuan ^b   Urlaub, Henning ^b,e   Paleček, Emil ^c   Jares Erijman, Elizabeth A ^d   Jovin, Thomas M ^b  

^a UNIVERSIDAD NACIONAL DE SANTIAGO DEL ESTERO   (Argentina)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Neurodegeneration; Oxidative stress; Parkinson's disease; Photocrosslinking; Protein aggregation; Protein photooxidation; SH SY5Y

Indexed keywords

ALPHA SYNUCLEIN; OLIGOMER; TRIS(2,2' BIPYRIDINE)RUTHENIUM; TYROSINE;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BIOPHYSICS; CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE; HUMAN; HUMAN CELL; LIGHT ABSORPTION; LIGHT SCATTERING; OLIGOMERIZATION; PHOTOSENSITIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STEADY STATE; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; AMMONIUM SULFATE; AMYLOID; CELL LINE; CELL SURVIVAL; CROSS-LINKING REAGENTS; FREE RADICALS; HUMANS; KINETICS; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; PHOTOCHEMICAL PROCESSES; PHOTOSENSITIZING AGENTS; PROTEIN STABILITY; TYROSINE;

EID: 84864965648     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.06.035     Document Type: Article

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