High-resolution differentiation of transmissible spongiform encephalopathy strains by quantitative N-terminal amino acid profiling (N-TAAP) of PK-digested abnormal prion protein

Journal of Mass Spectrometry

Volumn 44, Issue 3, 2009, Pages 384-396

  Glelbert, Adriana ^a   Davis, Linda A ^a   Sayers, A Robin ^a   Hope, James ^a   Gill, Andrew C ^b   Sauer, Maurice J ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Peptide fragmentation; Peptide quantification; Prion protein; Prion structure; Selected reaction monitoring; Strain differentiation; Transmissible spongiform encephalopathy

Indexed keywords

PEPTIDE FRAGMENTATION; PEPTIDE QUANTIFICATION; PRION PROTEIN; PRION STRUCTURE; SELECTED REACTION MONITORING; STRAIN DIFFERENTIATION; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY;

AGRICULTURE; AMINATION; AMINO ACIDS; DIAGNOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC ACIDS; PEPTIDES; SCANDIUM; STRAIN; WOOL;

AMINES;

AMINO ACID; PEPTIDE; PRION PROTEIN; PROTEINASE; PROTEINASE K; SYNAPSIN I;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BOVINE SPONGIFORM ENCEPHALOPATHY; DIFFERENTIAL DIAGNOSIS; FOOD CHAIN; LIVESTOCK; MASS SPECTROMETRY; MIGRATION; MONITORING; MULTIPLE SELECTED REACTION MONITORING; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; SCRAPIE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL MARKERS; BRAIN CHEMISTRY; CATTLE; CHROMATOGRAPHY, LIQUID; DIAGNOSIS, DIFFERENTIAL; ENCEPHALOPATHY, BOVINE SPONGIFORM; ENDOPEPTIDASE K; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PRION DISEASES; PRPSC PROTEINS; SCRAPIE; SEQUENCE ANALYSIS, PROTEIN; SHEEP; SHEEP DISEASES; TANDEM MASS SPECTROMETRY;

BOVINAE; OVIS ARIES;

EID: 62149128180     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1516     Document Type: Article

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