Oligomers of the prion protein fragment 106-126 are likely assembled from β-hairpins in solution, and methionine oxidation inhibits assembly without altering the peptide's monomeric conformation

Journal of the American Chemical Society

Volumn 132, Issue 2, 2010, Pages 532-539

  Grabenauer, Megan ^a   Wu, Chun ^a   Soto, Patricia ^a   Shea, Joan Emma ^a,b   Bowers, Michael T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CREIGHTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID FORMATION; CONTROL SEQUENCES; ION MOBILITY; ION MOBILITY SPECTROMETRY; METHIONINE OXIDATION; METHIONINE RESIDUES; METHIONINE SULFOXIDE; MONOMER SOLUTIONS; OLIGOMERIC STRUCTURE; PRION PROTEIN; RANDOM COIL; REPLICA EXCHANGE MOLECULAR DYNAMICS; SCRAMBLED SEQUENCE; SIMULATION DATA; STRUCTURAL COMPONENT;

AMINO ACIDS; CONFORMATIONS; INSULATING MATERIALS; ION EXCHANGE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MONOMERS; OLIGOMERIZATION; OLIGOMERS; ORGANIC ACIDS; OXIDATION; POPULATION STATISTICS; STRUCTURAL ANALYSIS;

PEPTIDES;

METHIONINE; METHIONINE SULFOXIDE; OLIGOMER; PRION PROTEIN; PRION PROTEIN 106 126; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BETA TURN; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; ION MOBILITY SPECTROMETRY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; OLIGOMERIZATION; OXIDATION; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE;

MASS SPECTROMETRY; METHIONINE; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PEPTIDES; PRIONS; PROTEIN CONFORMATION; SOLUTIONS;

EID: 74949142621     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja905595k     Document Type: Article

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