Quantitative profiling of PrPSc peptides by high-performance liquid chromatography mass spectrometry to investigate the diversity of prions

Analytical Biochemistry

Volumn 436, Issue 1, 2013, Pages 36-44

  Gielbert, Adriana ^a   Davis, Linda A ^a   Sayers, A Robin ^a   Tang, Yue ^a   Hope, James ^a   Sauer, Maurice J ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

Mass spectrometry; Multiplex assay; Prions; Protein misfolding; Scrapie; TSEs

Indexed keywords

AGGREGATES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; NEURODEGENERATIVE DISEASES; PEPTIDES;

MULTIPLEX ASSAYS; PRIONS; PROTEIN MISFOLDING; SCRAPIE; TSES;

PRASEODYMIUM COMPOUNDS;

PRION PROTEIN;

ARTICLE; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; WESTERN BLOTTING; WILD TYPE;

ANIMALIA; MAMMALIAN PRION; OVIS ARIES;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENOTYPE; LIMIT OF DETECTION; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PRPSC PROTEINS; SCRAPIE; SEQUENCE ANALYSIS, PROTEIN; SHEEP;

EID: 84874398957     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2013.01.015     Document Type: Article

References (28)

1. R.B. Wickner, H.K. Edskes, F. Shewmaker, D. Kryndushkin, and J. Nemecek Prion variants, species barriers, generation, and propagation J. Biol. 8 2009 47
2. S.B. Prusiner Novel proteinaceous infectious particles cause scrapie Science 216 1982 136 144
3. S.B. Prusiner Molecular biology of prion diseases Science 252 1991 1515 1522
4. G.S. Jackson, and J. Collinge Prion disease - the propagation of infectious protein topologies Microbes Infect. 2 2000 1445 1449
5. W. Goldmann, N. Hunter, J.D. Foster, J.M. Salbaum, K. Beyreuther, and J. Hope Two alleles of a neural protein gene linked to scrapie in sheep Proc. Natl. Acad. Sci. U.S.A. 87 1990 2476 2480
6. M. Baylis, and W. Goldmann The genetics of scrapie in sheep and goats Curr. Mol. Med. 4 2004 385 396
7. J. Hope, G. Multhaup, L.J.D. Reekie, R.H. Kimberlin, and K. Beyreuther Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie Eur. J. Biochem. 172 1988 271 277
8. J. Hope, S.C. Wood, C.R. Birkett, A. Chong, M.E. Bruce, D. Cairns, W. Goldmann, N. Hunter, and C.J. Bostock Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641 J. Gen. Virol. 80 1999 1 4
9. P. Parchi, W. Zou, W. Wang, P. Brown, S. Capellari, B. Ghetti, N. Kopp, W.J. Schulz-Schaeffer, H.A. Kretzschmar, M.W. Head, J.W. Ironside, P. Gambetti, and S.G. Chen Genetic influence on the structural variations of the abnormal prion protein Proc. Natl. Acad. Sci. U.S.A. 97 2000 10168 10172
10. M.J. Stack, M.J. Chaplin, and J. Clark Differentiation of prion protein glycoforms from naturally occurring sheep scrapie, sheep-passaged scrapie strains (CH1641 and SSBP1), bovine spongiform encephalopathy (BSE) cases, and Romney and Cheviot breed sheep experimentally inoculated with BSE using two monoclonal antibodies Acta Neuropathol. 104 2002 279 286
11. R. Nonno, E. Esposito, G. Vaccari, M. Conte, S. Marcon, M. DiBari, C. Ligios, G. DiGuardo, and U. Agrimi Molecular analysis of cases of Italian sheep scrapie and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep J. Clin. Microbiol. 41 2003 4127 4133
12. R.A. Somerville, A. Chong, O.U. Mulqueen, C.R. Birkett, S.C.E.R. Wood, and J. Hope Biochemical typing of scrapie strains Nature 386 1997 564
13. V. Smirnovas, G.S. Baron, D.K. Offerdahl, G.J. Raymond, B. Caughey, and W.K. Surewicz Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange Nat. Struct. Mol. Biol. 18 2011 504 506
14. Sc typing by N-terminal sequencing and mass spectrometry Arch. Virol. Suppl. 16 2000 209 216
15. G. Sajnani, M.A. Pastrana, I. Dynin, B. Onisko, and J.R. Requena Scrapie prion protein structural constraints obtained by limited proteolysis and mass spectrometry J. Mol. Biol. 382 2008 88 98
16. A. Gielbert, L.A. Davis, A.R. Sayers, J. Hope, A.C. Gill, and M.J. Sauer High-resolution differentiation of transmissible spongiform encephalopathy strains by quantitative N-terminal amino acid profiling (N-TAAP) of PK-digested abnormal prion protein J. Mass Spectrom. 44 2009 384 396
17. Advisory Committee for Dangerous Pathogens and Spongiform Encephalopathy Advisory Committee, Part 3: Containment and Control Measures for Experimental Laboratory Work with TSE Agents, Materials, and Infected, Animals, 1998.
18. S. Ryder, G. Dexter, S. Bellworthy, and S. Tongue Demonstration of lateral transmission of scrapie between sheep kept under natural conditions using lymphoid tissue biopsy Res. Vet. Sci. 76 2004 211 217
19. M.J. Stack Western immunoblotting techniques for the study of TSEs S. Lehmann, J. Grassi, Techniques in Prion Research 2004 Birkhäuser Verlag Berlin 97 116
20. S. Thió-Henestrosa, and J.A. Martín-Fernández Detailed Guide to CoDaPack: A Freeware Compositional Software 2006 Geological Society/Special Publications London pp. 101-118
21. S.J. Ryder, Y.I. Spencer, P.J. Bellerby, and S.A. March Immunohistochemical detection of PrP in the medulla oblongata of sheep: the spectrum of staining in normal and scrapie-affected sheep Vet. Rec. 148 2001 7 13
22. L. Gonzalez, S. Martin, I. Begara-McGorum, N. Hunter, F. Houston, M. Simmons, and M. Jeffrey Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie J. Comp. Pathol. 126 2002 17 29
23. L. Gonzalez, S. Siso, E. Monleon, C. Casalone, L.J. van Keulen, A. Balkema-Buschmann, A. Ortiz-Pelaez, B. Iulini, J.P. Langeveld, C. Hoffmann, J.J. Badiola, M. Jeffrey, and C. Acin Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe J. Gen. Virol. 91 2010 2630 2641
24. Sc spreading patterns in the brain of sheep linked to different prion types Vet. Res. 42 2011 32
25. B. Onisko, I. Dynin, J.R. Requena, C.J. Silva, M. Erickson, and J.M. Carter Mass spectrometric detection of attomole amounts of the prion protein by nanoLC/MS/MS J. Am. Soc. Mass Spectrom. 18 2007 1070 1079
26. Sc from scrapie-infected and bovine spongiform encephalopathy-infected mice Biomarkers 13 2008 393 412
27. L. Thorne, T. Holder, A. Ramsay, J. Edwards, M.M. Taema, B.C. Maddison, K.C. Gough, and L.A. Terry In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation BMC Vet. Res. 8 2012 223
28. d immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing J. Gen. Virol. 84 2003 1339 1350