Hepatic cytochrome P450 ubiquitination: Conformational phosphodegrons for E2/E3 recognition?

IUBMB Life

Volumn 66, Issue 2, 2014, Pages 78-88

  Correia, Maria Almira ^a,b   Wang, Yongqiang ^a   Kim, Sung Mi ^a   Guan, Shenheng ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytochromes P450; E2 E3 ligases; ERAD; hemeproteins; phosphorylation; proteasomal degradation; ROS

Indexed keywords

CARCINOGEN; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; GLUCOSE 6 PHOSPHATE ISOMERASE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; LIGASE; LIVER PROTEIN; MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; UNSPECIFIC MONOOXYGENASE;

CELL ORGANELLE; CELL SURFACE; CONFORMATIONAL TRANSITION; CROSS LINKING; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; NONHUMAN; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REVIEW; TANDEM MASS SPECTROMETRY; TETRATRICOPEPTIDE REPEAT; UBIQUITINATION;

CYTOCHROMES P450; E2/E3 LIGASES; ERAD; HEMEPROTEINS; PHOSPHORYLATION; PROTEASOMAL DEGRADATION; ROS;

CYTOCHROME P-450 ENZYME SYSTEM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HEMEPROTEINS; HUMANS; LIVER; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; REACTIVE OXYGEN SPECIES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84896397416     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1247     Document Type: Review

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