Native CYP2C11: Heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum protein

Molecular Pharmacology

Volumn 61, Issue 5, 2002, Pages 1146-1153

  Murray, Bernard P ^a,b   Zgoda, Victor G ^a,b   Correia, Maria Almira ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYTOCHROME P450 2C11; CYTOCHROME P450 3A4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PROTEASOME; PROTEINASE;

ARTICLE; CELL VACUOLE; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME MECHANISM; GENE EXPRESSION; GENE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; XENOBIOTIC METABOLISM;

ARYL HYDROCARBON HYDROXYLASES; CYSTEINE ENDOPEPTIDASES; CYTOCHROME P-450 ENZYME SYSTEM; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, FUNGAL; MULTIENZYME COMPLEXES; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; VACUOLES; VARIATION (GENETICS);

EID: 0036233468     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.5.1146     Document Type: Article

References (47)

1. Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells
2. Identification of a ubiquitination-target/substrate-interaction domain of cytochrome P-450 (CYP) 2E1
3. Hrd1p is a membrane-anchored ubiquitin ligase required for endoplasmic reticulum-associated degradation
4. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
5. Role of Cuelp in ubiquitination and degradation at the ER surface
6. Membrane topology of liver microsomal cytochrome P450 2B4 determined via monoclonal antibodies directed to the halttransfer signal
7. Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
8. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT α2 repressor
9. Cytochrome P450 turnover
10. Degradation of rat liver cytochromes P-450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-l,4-dihydropyridine: Characterization of the proteolytic system
11. Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies
12. Control of protein degradation in reticulocytes and reticulocyte extracts by hemin
13. Endoplasmic reticulum degradation requires lumen to cytosol signaling transmembrane control of hrdlp by hrd3p
14. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase
15. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
16. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast
17. Expression of a rat liver microsomal cytochrome P-450 catalyzing testosterone 16a-hydroxylation in Saccharomyces cerevisiae: Vitamin D3 25-hydroxylase and testosterone 16a-hydroxylase are distinct forms of cytochrome P-450
18. The ubiquitin system
19. Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system
20. Cytochrome P-450 membrane signals
21. Proteolytic degradation of Heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination and the 26S proteasome?
22. 1,-antitrypsin variant are degraded within the endoplasmic retieulum reticulum by a mechanism sensitive to inhibitors of protein synthesis
23. Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver
24. Degradation of 3-hydroxy-3-methylglutaryi-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis
25. Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane
26. Ubiquitin-dependent 26S proteasomal pathway: A role in the degradation of "native" CYP3A4 in Saccharomyces cerevisiae
27. Oxygen activation and reactivity, in Cytochrome P-450: Structure
28. Inhibition of cytochrome P450 enzymes, in Cytochrome P-450: Structure
29. Differential inhibition of hepatic ferrochelatase by the isomers of N-ethylprotoporphyrin IX
30. Genetic interactions of Hrd3p and Der3p/Hrdlp with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation
31. Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome
32. 1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity
33. Evidence of proteasome-mediated cytochrome P-450 degradation
34. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1
35. Acetone-regulated synthesis and degradation of cytochrome P450E1 and cytochrome P4502131 in rat liver
36. The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane
37. Turnover of membrane proteins: Kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase
38. Endoplasmic reticulum degradation: Reverse protein flow of no return
39. Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization
40. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits-involvement of ER-associated ubiquitin-conjugating enzymes (E2s)
41. CYP 3A degradation in isolated rat liver hepatocytes: 26S Proteasome inhibitors as probes
42. Degradation of CFTR by the ubiquitinproteasome pathway
43. Degradation of the hepatic cytochromes P-450
44. Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate
45. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
46. HRD gene dependence of endoplasmic reticulum-associated degradation
47. Characterization of cytochrome P4502E1 turnover in transfected HEPG2 cells expressing human CYP2E1