Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b 5

Biochemistry

Volumn 51, Issue 47, 2012, Pages 9488-9500

  Zhao, Chunsheng ^a   Gao, Qiuxia ^a   Roberts, Arthur G ^c   Shaffer, Scott A ^b   Doneanu, Catalin E ^a   Xue, Song ^d   Goodlett, David R ^a   Nelson, Sidney D ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d MICROSOFT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; CHEMICAL CROSS-LINKING; CYTOCHROME B; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; ELECTRON TRANSFER; INTERACTING SITES; ISOFORMS; MASS SPECTROMETRIC ANALYSIS; MONOOXYGENASES; PROTEIN SURFACE; SUBSTRATE RECOGNITION SITES; SURFACE INTERACTIONS; UNDERLYING MECHANISM;

BINDING ENERGY; CROSSLINKING; ELECTROSTATICS; MASS SPECTROMETRY; PROTEINS;

MUTAGENESIS;

CYTOCHROME B5; CYTOCHROME P450 3A4; CYTOCHROME P450 REDUCTASE; HOLOENZYME;

ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; MASS SPECTROMETRY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION;

BINDING SITES; CROSS-LINKING REAGENTS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; CYTOCHROMES B5; ETHYLDIMETHYLAMINOPROPYL CARBODIIMIDE; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; STEROID HYDROXYLASES; TESTOSTERONE;

RUMEX;

EID: 84870202411     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301069r     Document Type: Article

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