Liver Cytochrome P450 3A endoplasmic reticulum-associated degradation: A major role for the P97 AAA ATPase in cytochrome P450 3A extraction into the cytosol

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3815-3828

  Acharya, Poulomi ^a   Liao, Mingxiang ^a   Engel, Juan C ^a   Correia, Maria Almira ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

26 S PROTEASOME; APOPTOSIS; CELLULAR MORPHOLOGY; CELLULAR PROCESS; CYTOCHROME P450; CYTOCHROMES P450; CYTOSOLIC; CYTOSOLS; DRUG-DRUG INTERACTIONS; ENDOPLASMIC RETICULUM; ER STRESS; HEMOPROTEINS; IN-VIVO; PROTEASOMAL DEGRADATION; PROTEASOMES; RAT HEPATOCYTES; UBIQUITIN;

CELL DEATH; DEGRADATION; DRUG INTERACTIONS;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; CYTOCHROME P450 3A; MESSENGER RNA; PROTEIN P97; SHORT HAIRPIN RNA; ATP DEPENDENT 26S PROTEASE; NUCLEAR PROTEIN; P97 ATPASE; PROTEASOME; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CELL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; LENTIVIRINAE; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; UBIQUITINATION; ANIMAL; CELL CULTURE; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; CYTOSOL; ENDOPLASMIC RETICULUM; HEPATOCYTES; MALE; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

EID: 79952806487     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.186981     Document Type: Article

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