Reaction of human cytochrome P450 3A4 with peroxynitrite: Nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase

Chemical Research in Toxicology

Volumn 25, Issue 12, 2012, Pages 2642-2653

  Lin, Hsia Lien ^a   Kenaan, Cesar ^a   Zhang, Haoming ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 7 BENZYLOXY 4 (TRIFLUOROMETHYL)COUMARIN; AROMATIC COMPOUND; COUMARIN DERIVATIVE; CYTOCHROME P450 3A4; DITHIONITE; HYDROXYL GROUP; PEROXYNITRITE; PHENYLALANINE; PROTEINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; TERT BUTYL HYDROPEROXIDE; TRYPSIN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ACIDITY; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEBENZYLATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; LIQUID CHROMATOGRAPHY; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR WEIGHT; MUTAGENESIS; NITRATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY;

CYTOCHROME P-450 CYP3A; DITHIONITE; HUMANS; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PEPTIDES; PEROXYNITROUS ACID; PROTEIN CONFORMATION; TYROSINE;

EID: 84871233446     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3002753     Document Type: Article

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