Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase

Journal of Biological Chemistry

Volumn 278, Issue 15, 2003, Pages 13480-13486

  Henderson, Colin J ^c   Otto, Diana M E ^c   Carrie, Dianne ^c   Magnuson, Mark A ^a   McLaren, Aileen W ^c   Rosewell, Ian ^b   Wolf, C Roland ^c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHOLESTEROL; METABOLISM; TOXICITY;

ENDOGENOUS COMPOUNDS;

BIOCHEMISTRY;

BILE ACID; CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; LIVER ENZYME; PARACETAMOL; PENTOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; STEROID HORMONE; TRIACYLGLYCEROL; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT; GLUTATHIONE; SERUM ALBUMIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG DISPOSITION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; FEMALE; FERTILITY; GENE DELETION; GENE EXPRESSION REGULATION; HOMEOSTASIS; HORMONE METABOLISM; LIVER METABOLISM; LIVER MICROSOME; MALE; METABOLIC ACTIVATION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; OXIDATION; PRIORITY JOURNAL; ANIMAL; DRUG EFFECT; ENZYMOLOGY; EXON; GENE LIBRARY; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; PROMOTER REGION; RAT; RESTRICTION MAPPING; SEXUAL DEVELOPMENT; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA;

ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; EXONS; FEMALE; GENE DELETION; GENOMIC LIBRARY; GLUTATHIONE; LIVER; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NADPH-FERRIHEMOPROTEIN REDUCTASE; PENTOBARBITAL; PROMOTER REGIONS (GENETICS); RATS; RESTRICTION MAPPING; SERUM ALBUMIN; SEX CHARACTERISTICS;

EID: 0037790603     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212087200     Document Type: Article

References (52)

1. Wolf, C. R. (1986) Trends Genet. 2, 209-214
2. Raucy, J. L., and Allen, S. W. (2001) Pharmacogen. J. 1, 178-186
3. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., and Nebert, D. W. (1996) Pharmacogenetics 6, 1-42
4. Pikuleva, I., and Waterman, M. (1999) Mol. Aspects Med. 20, 33-42,43-37
5. Omura, T. (1999) Biochem. Biophys. Res. Commun. 266, 690-698
6. Goeptar, A. R., Scheerens, H., and Vermeulen, N. P. (1995) Crit. Rev. Toxicol. 25, 25-65
7. Smith, G. C., Tew, D. G., and Wolf, C. R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8710-8714
8. Shen, A. L., O'Leary, K. A., and Kasper, C. B. (2002) J. Biol. Chem. 277, 6536-6541
9. Le, Y., and Sauer, B. (2001) Mol. Biotechnol. 17, 269-275
10. Postic, C., Shiota, M., Niswender, K. D., Jetton, T. L., Chen, Y., Moates, J. M., Shelton, K. D., Lindner, J., Cherrington, A. D., and Magnuson, M. A. (1999) J. Biol. Chem. 274, 305-315
11. Brochet, D., Chermat, R., DeFeudis, F. V., and Drieu, K. (1999) Gen. Pharmacol. 33, 249-256
12. Meehan, R. R., Forrester, L. M., Stevenson, K., Hastie, N. D., Buchmann, A., Kunz, H. W., and Wolf, C. R. (1988) Biochem. J. 254, 789-797
13. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
14. Henderson, C. J., and Wolf, C. R. (1992) in Immunochemical Protocols (Manson, M. M., ed) Vol. 10, pp. 221-234, Humana Press, Totowa, NJ
15. Forrester, L. M., Henderson, C. J., Glancey, M. J., Back, D. J., Park, B. K., Ball, S. E., Kitteringham, N. R., McLaren, A. W., Miles, J. S., Skett, P., and Wolf, C. R. (1992) Biochem. J. 281, 359-368
16. Sen, C. K., Marin, E., Kretzschmar, M., and Hanninen, O. (1992) J. Appl. Physiol. 73, 1265-1272
17. Henderson, C. J., Scott, A. R., Yang, C. S., and Wolf, C. R. (1990) Biochem. J. 266, 675-681
18. Lamb, D. C., Kelly, D. E., Manning, N. J., Kaderbhai, M. A., and Kelly, S. L. (1999) FEBS Lett. 462, 283-288
19. Oinonen, T., and Lindros, K. O. (1998) Biochem. J. 329, 17-35
20. Wolf, C. R., Moll, E., Friedberg, T., Oesch, F., Buchmann, A., Kuhlmann, W. D., and Kunz, H. W. (1984) Carcinogenesis 5, 993-1001
21. Modi, S., Lian, L. Y., Roberts, G. C., Smith, G. C., Paine, M., and Wolf, C. R. (1995) Biochem. Soc. Trans. 23, 476S
22. Voice, M. W., Zhang, Y., Wolf, C. R., Burchell, B., and Friedberg, T. (1999) Arch. Biochem. Biophys. 366, 116-124
23. Stromstedt, M., Rozman, D., and Waterman, M. R. (1996) Arch. Biochem. Biophys. 329, 73-81
24. Kelly, S. L., Lamb, D. C., Cannieux, M., Greetham, D., Jackson, C. J., Marczylo, T., Ugochukwu, C., and Kelly, D. E. (2001) Biochem. Soc. Trans. 29, 122-128
25. Schwarz, M., Russell, D. W., Dietschy, J. M., and Turley, S. D. (1998) J. Lipid Res. 39, 1833-1843
26. Ishibashi, S., Schwarz, M., Frykman, P. K., Herz, J., and Russell, D. W. (1996) J. Biol. Chem. 271, 18017-18023
27. Schwarz, M., Lund, E. G., Setchell, K. D., Kayden, H. J., Zerwekh, J. E., Bjorkhem, I., Herz, J., and Russell, D. W. (1996) J. Biol. Chem. 271, 18024-18031
28. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
29. Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., and Goldstein, J. L. (1996) J. Clin. Invest. 98, 1575-1584
30. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M., and Gonzalez, F. J. (2001) Mol. Cell. Biol. 21, 1393-1403
31. Jover, R., Bort, R., Gomez-Lechon, M. J., and Castell, J. V. (2001) Hepatology 33, 668-675
32. Cairns, W., Smith, C. A., McLaren, A. W., and Wolf, C. R. (1996) J. Biol. Chem. 271, 25269-25276
33. Spady, D. K., and Dietschy, J. M. (1983) J. Lipid Res. 24, 303-315
34. Repa, J. J., and Mangelsdorf, D. J. (2000) Annu. Rev. Cell Dev. Biol. 16, 459-481
35. Dietschy, J. M., Spady, D. K., and Stange, E. F. (1983) Biochem. Soc. Trans. 11, 639-641
36. Carter, C. P., Howles, P. N., and Hui, D. Y. (1997) J. Nutr. 127, 1344-1348
37. Bosner, M. S., Lange, L. G., Stenson, W. F., and Ostlund, R. E., Jr. (1999) J. Lipid Res. 40, 302-308
38. Kang, S., and Davis, R. A. (2000) Biochim. Biophys. Acta 1529, 223-230
39. Repa, J. J., Lund, E. G., Horton, J. D., Leitersdorf, E., Russell, D. W., Dietschy, J. M., and Turley, S. D. (2000) J. Biol. Chem. 275, 39685-39692
40. Li-Hawkins, J., Lund, E. G., Turley, S. D., and Russell, D. W. (2000) J. Biol. Chem. 275, 16536-16542
41. Simpson, A. E. (1997) Gen. Pharmacol. 28, 351-359
42. Tonge, R. P., Kelly, E. J., Bruschi, S. A., Kalhorn, T., Eaton, D. L., Nebert, D. W., and Nelson, S. D. (1998) Toxicol. Appl. Pharmacol. 153, 102-108
43. Lee, S. S. T., Buters, J. T. M., Oineau, T., Fernandez-Salguero, P., and Gonzalez, F. J. (1996) J. Biol. Chem. 271, 12063-12067
44. Zhang, J., Huang, W., Chua, S. S., Wei, P., and Moore, D. D. (2002) Science 298, 422-424
45. Coles, B., Wilson, I., Wardman, P., Hinson, J. A., Nelson, S. D., and Ketterer, B. (1988) Arch. Biochem. Biophys. 264, 253-260
46. Henderson, C. J., Wolf, C. R., Kitteringham, N., Powell, H., Otto, D., and Park, B. K. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12741-12745
47. Hines, R. N., Luo, Z., Cresteil, T., Ding, X., Prough, R. A., Fitzpatrick, J. L., Ripp, S. L., Falkner, K. C., Ge, N. L., Levine, A., and Elferink, C. J. (2001) Drug Metab. Dispos. 29, 623-633
48. Conney, A. H. (1982) Cancer Res. 42, 4875-4917
49. Sundseth, S. S., Alberta, J. A., and Waxman, D. J. (1992) J. Biol. Chem. 267, 3907-3914
50. Shapiro, B. H., MacLeod, J. N., Pampori, N. A., Morrissey, J. J., Lapenson, D. P., and Waxman, D. J. (1989) Endocrinology 125, 2935-2944
51. Tzameli, I., Pissios, P., Schuetz, E. G., and Moore, D. D. (2000) Mol. Cell. Biol. 20, 2951-2958
52. Smith, G., Henderson, C. J., Parker, M. G., White, R., Bars, R. G., and Wolf, C. R. (1993) Biochem. J. 289, 807-813