Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 42601-42610

  Clapp, Kelly M ^a   Peng, Hwei Ming ^a   Jenkins, Gary J ^a   Ford, Michael J ^b   Morishima, Yoshihiro ^a   Lau, Miranda ^a   Osawa, Yoichi ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MS BIOWORKS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CYTOCHROME P450; DEPENDENT PROCESS; HEK293 CELLS; HEMOPROTEINS; IN-VITRO; LARGE PARTS; LC-MS/MS; MUTATIONAL ANALYSIS; NEURONAL NITRIC-OXIDE SYNTHASE (NNOS); NITRIC-OXIDE SYNTHASE; OXYGENASES; PHYSIOLOGICAL PROCESS; POLYUBIQUITINATION; PROTEASOMAL DEGRADATION; SIGNALING MOLECULES; TRYPTIC PEPTIDES; UBIQUITINATION;

AMINO ACIDS; CALMODULIN; NITRIC OXIDE;

LEAD OXIDE;

CALMODULIN; GLYCOPROTEIN E1; GLYCOPROTEIN E2; HEAT SHOCK PROTEIN 70; LYSINE; NEURONAL NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; OXYGENASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; LINKAGE ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALMODULIN; CHROMATOGRAPHY, LIQUID; HEK293 CELLS; HEME; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LYSINE; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; NITRIC OXIDE SYNTHASE TYPE I; NITROARGININE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEOLYSIS; RATS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84871154311     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.412494     Document Type: Article

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