Relationship between cytochrome P450 catalytic cycling and stability: Fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase

Biochemical Journal

Volumn 340, Issue 2, 1999, Pages 453-458

  Zhukov, Andrei ^a   Ingelman Sundberg, Magnus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Diphenylene iodonium; Endoplasmic reticulum; Membrane proteins; Protein degradation; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; CYTOTOXIN; DIPHENYLIODONIUM SALT; ENZYME INDUCING AGENT; FLAVOPROTEIN; HEME; IRON; LIGAND; MICROSOME ENZYME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; GLUCONEOGENESIS; HALF LIFE TIME; HEPATOMA CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SERUM;

ADENOSINE TRIPHOSPHATE; ANIMALS; CATALYSIS; CYTOCHROME P-450 CYP2E1; ELECTRONS; ENZYME INDUCTION; ENZYME STABILITY; ETHANOL; HYDROGEN PEROXIDE; LIVER NEOPLASMS, EXPERIMENTAL; MICROSOMES, LIVER; NADH, NADPH OXIDOREDUCTASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; ONIUM COMPOUNDS; PROTEIN BINDING; RATS; TUMOR CELLS, CULTURED;

EID: 0033151930     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3400453     Document Type: Article

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