Plant natural products as an anti-lipid droplets accumulation agent

Journal of Natural Medicines

Volumn 68, Issue 2, 2014, Pages 253-266

  Wong, Chin Piow ^a   Kaneda, Toshio ^a   Morita, Hiroshi ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Adipocyte; Anti adipogenesis; Anti lipid droplets accumulation; Drug lead; Plant natural products

Indexed keywords

ALBIZIA JULIBRISSIN EXTRACT; ARISTOLOCHIA MANSHURIENSIS EXTRACT; ARISTOLOCHIC ACID; BETA CRYPTOXANTHIN; CAPSAICIN; CERAMICINE B; CHISOCHETON CERAMICUS EXTRACT; CURCUMA LONGA EXTRACT; CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; EPIGALLOCATECHIN GALLATE; EPIMAGNOLIN A; EUDSMIN; FARGESIN; FOENUMOSIDE B; LICOCHALCONE A; LYSIMACHIA FOENUM-GRAECUM EXTRACT; MAGNOLIA DENUDATA EXTRACT; MAGNOLIN; NATURAL PRODUCT; NELUMBO NUCIFERA EXTRACT; NEPETA JAPONICA EXTRACT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POPULUS BALSAMIFERA EXTRACT; SALICIN; SALICORTIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINGIBER MIOGA EXTRACT;

ADIPOGENESIS; ALBIZIA JULIBRISSIN; ARISTOLOCHIA MANSHURIENSIS; CHISOCHETON CERAMICUS; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; LIPID STORAGE; LIPOGENESIS; LYSIMACHIA FOENUM-GRAECUM; MAGNOLIA DENUDATA; MEDICINAL PLANT; NELUMBO NUCIFERA; NEPETA JAPONICA; NONHUMAN; OBESITY; POPULUS BALSAMIFERA; REVIEW; SATSUMA; ZINGIBER MIOGA;

ADIPOCYTES; HUMANS; LIPID METABOLISM; PLANT EXTRACTS;

EID: 84896396283     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-014-0822-3     Document Type: Review

References (146)

1. Trayhum P, Beattie JH (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60:329-339
2. Vidal-Puig AJ, Sethi JK (2007) Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res 48:1253-1262
3. Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. Int J Clin Endocrinol Metab 89(6):2548-2556
4. Willett WC, Manson JE, Stampfer MJ, Colditz GA, Rosner B, Speizer FE, Hennekens CH (1995) Weight, weight change, and coronary heart disease in women: risk within the "normal" weight range. J Am Med Assoc 273:461-465
5. Haslam DW, James WP (2005) Obesity. Lancet 366:1197-1209
6. Hu Y, Davies GE (2010) Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. Fitoterapia 81:358-366
7. Beekum O, Fleskens V, Kalkhoven E (2009) Posttranslational modifications of PPAR-γ: fine-tuning the metabolic master regulator. Obesity 17:213-219
8. Kim HK, Nelson-Dooley C, Della-Fera MA, Yang JY, Zhang W, Duan J, Hartzell DL, Hamrick MW, Baile CA (2006) Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice. J Nutr 136(2):409-414
9. Sarma DN, Barrett ML, Chavez ML, Gardiner P, Ko R, Mahady GB, Marles RJ, Pellicore LS, Giancaspro GI, Low DT (2008) Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf 31:469-484
10. Asai A, Miyazawa T (2001) Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr 131(11):2932-2935
11. Lowell BB, Flier JS (1997) Brown adipose tissue, beta 3-adrenergic receptors and obesity. Annu Rev Med 48:307-316
12. Rodeheffer MS, Birsoy K, Friedman JM (2008) Identification of white adipocyte progenitor cells in vivo. Cell 135:240-249
13. Huang H, Song TJ, Li X, Hu L, He Q, Liu M, Lane MD, Tang QQ (2009) BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 106:12670-12675
14. Zamani N, Brown C (2010) Emerging roles for the transforming growth factor-beta superfamily in regulating adiposity and energy expenditure. Endrocr Rev 32:387-403
15. Kawai M, Rosen CJ (2010) The IGF-I regulatory system and its impact on skeletal and energy homeostasis. J Cell Biochem 111(1):14-19
16. Zúñiga LA, Shen WJ, Joyce-Shaikh B, Pyatnova EA, Richards AG, Thom C, Andrade SM, Cua DJ, Kraemer FB, Butcher EC (2010) IL-17 regulates adipogenesis, glucose homeostasis, and obesity. J Immunol 185:6947-6959
17. Widberg CH, Newell FS, Bachmann AW, Ramnoruth SN, Spelta MC, Whitehead JP, Hutley LJ, Prins JB (2009) Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes. Am J Physiol Endocinol Metab 296:121-131
18. Xiao L, Sobue T, Esliger A, Kronenberg MS, Coffin JD, Doetschman T, Hurley MM (2010) Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone 47:360-370
19. Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri E, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland J, Dani C (2010) Activin A plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes 59:2513-2521
20. Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K (2007) Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway. J Mol Endocrinol 38:19-34
21. Rosen ED, MacDougald OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7:885-896
22. White UA, Stephens JM (2010) Transcriptional factors that promote formation of white adipose tissue. Mol Cell Endocrinol 318:10-14
23. James DE, Brown R, Navarro J, Pilch PF (1988) Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature 333(6169):183-185
24. Mead JR, Irvine SA, Ramji DP (2002) Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med 80(12):753-769
25. Seckl JR, Walker BR (2001) Minireview: 11β-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action. Endocrinology 142(4):1371-1376
26. Seckl JR (1997) 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action? Front Neuroendocrinol 18(1):49-99
27. Anagnostis P, Athyros VG, Tziomalos K, Karagiannis A, Mikhailidis DP (2009) The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab 94(8):2692-2701
28. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989) Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. Biochemistry 28(22):8683-8690
29. Christiansen K, Jensen PK (1972) Membrane-bound lipid particles from beef heart. Chemical composition and structure. Biochim Biophys Acta 260:449-459
30. Lass A, Zimmermann R, Oberer M, Zechner R (2011) Lipolysis - A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 50:14-27
31. Zweytick D, Athenstaedt K, Daum G (2000) Intracellular lipid particles of eukaryotic cells. Biochim Biophys Acta 1469:101-120
32. Ohsaki Y, Cheng J, Suzuki M, Shinohara Y, Fujita A, Fujimoto T (2009) Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure. Biochim Biophys Acta 1791:399-407
33. Brasaemle DL (2007) Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res 48:2547-2559
34. Reue K (2011) A thematic review series: lipid droplet storage and metabolism: from yeast to man. J Lipid Res 52:1865-1868
35. Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS (2007) Regulation of lipolysis in adipocytes. Annu Rev Nutr 27:79-101
36. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306:1383-1386
37. Fredrickson G, Strålfors P, Nilsson NÖ, Belfrage P (1981) Hormone-sensitive lipase of rat adipose tissue. Purification and some properties. J Biol Chem 256:6311-6320
38. Kwak DH, Lee JH, Kim T, Ahn HS, Cho WK, Ha H, Hwang YH, Ma JY (2012) Aristolochia manshuriensis Kom inhibits adipocyte differentiation by regulation of ERK1/2 and Akt pathway. PLOS one 7(11):e49530
39. Shibata S (2000) A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 120:849-862
40. Quan HY, Baek NI, Chung SH (2012) Licochalcone A prevents adipocyte differentiation and lipogenesis via suppression of peroxisome proliferator-activated receptor γ and sterol regulatory element-binding protein pathways. J Agri Chem 60:5112-5120
41. Lin J, Della-Fera MA, Baile CA (2005) Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obes Res 13:982-990
42. Söhle J, Knott A, Holtzmann U, Siegner R, Grönniger E, Schepky A, Gallinat S, Wenck H, Stäb F, Winnefeld M (2009) White tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes. Nutr Metab (Lond). 20(6)
43. Kim H, Sakamoto K (2012) (-)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways. Cell Biol Int 36(2):147-153
44. Han LK, Takaku T, Li J, Kimura Y, Okuda H (1999) Anti-obesity action of oolong tea. Int J Obes 23:98-105
45. Sayama K, Lin S, Zheng G, Oguni I (2000) Effects of green tea on growth, food utilization and lipid metabolism in mice. In Vivo 14:481-484
46. Han LK, Kimura Y, Kawashima M, Takaku T, Taniyama T, Hayashi T, Zheng YN, Okuda H (2001) Anti-obesity effects in rodents of dietary tea saponin, a lipase inhibitor. Int J Obes 25:1459-1464
47. Mohamad K, Hirasawa Y, Lim CS, Awang K, Hadi AHA, Takeya K, Morita H (2008) Ceramicine A and walsogyne A, novel limonoids from two species of Meliaceae. Tetrahedron Lett 49:4276-4278
48. Mohamad K, Hirasawa Y, Litaudon M, Awang K, Hadi AHA, Takeya K, Ekasari W, Widyawaruyanti A, Zaini NC, Morita H (2009) Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus. Bioorg Med Chem 17:727-730
49. Wong CP, Shimada M, Nagakura Y, Nugroho AE, Hirasawa Y, Kaneda T, Awang K, Hadi AHA, Mohamad K, Shiro M, Morita H (2011) Ceramicines E-I, New Limonoids from Chisocheton ceramicus. Chem Pharm Bull 59:407-411
50. Wong CP, Shimada M, Nugroho AE, Hirasawa Y, Kaneda T, Awang K, Hadi AHA, Mohamad K, Shiro M, Morita H (2012) Ceramicines J-L, New Limonoids from Chisocheton ceramicus. J Nat Med 66:566-570
51. Najmuldeen IA, Hadi AH, Awang K, Mohamad K, Chong SL, Chan G, Nafiah MA, Weng NS, Shirota O, Hosoya T, Nugroho AE, Morita H (2011) Chisomicines A-C, Limonoids from Chisocheton ceramicus. J Nat Prod 74(5):1313-1317
52. Najmuldeen IA, Hadi AH, Mohamad K, Awang K, Ketuly KA, Mukhtar MR, Taha H, Nordin N, Litaudon M, Guéritte F, Nugroho AE, Morita H (2012) Chisomicines A-C, Two New Limonoids from Chisocheton ceramicus. Heterocycles 84(2):1265-1270
53. Najmuldeen IA, Hadi AH, Awang K, Mohamad K, Ng SW (2010) 14-Deoxyxyloccensin K from Chisocheton ceramicus (Meliaceae). Acta Crystallographica Section E 66:1927
54. Wong CP, Kaneda T, Hadi AHA, Morita H (2013) Ceramicine B, a limonoid with anti-lipid droplets accumulation activity from Chisocheton ceramicus. J Nat Med 68(1):22-30
55. Wong CP, Deguchi J, Nugroho AE, Kaneda T, Hadi AHA, Morita H (2013) Ceramcines from Chisocheton ceramicus as lipid-droplets accumulation inhibitors. Bioorg Med Chem Lett 23:1786-1788
56. Munekata K, Sakamoto K (2009) Forkhead transcription factor Foxo1 is essential for adipocyte differentiation. In Vitro Cell Dev Biol 45:642-651
57. Armoni M, Harel C, Karni S, Chen H, Bar-Yoseph F, Ver MR, Quon MJ, Karnieli E (2006) FOXO1 represses PPARγ1 and PPARγ2 gene promoters in primary adipocytes: a novel paradigm to increase insulin sensitivity. J Bio Chem 281(29):19881-19891
58. Seo JB, Choe SS, Jeong HW, Park SW, Shin HJ, Choi SM, Park JY, Choi EW, Kim JB, Seen DS, Jeong JY, Lee TG (2011) Anti-obesity effect of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism. Exp Mol Med 43(4):205-215
59. Shen YH, Weng ZY, Zhao QS, Zeng YQ, Rios JL, Xiao WL, Xu G, Sun HD (2005) Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on arachidonic acid metabolizing enzyme. Planta Med 71:770-775
60. Li XR, Li ZM, Du SS, Wang GL, Lin RC (2009) Two triterpenes from Lysimachia foenum-graecum. J Asian Nat Prod Res 11:128-131
61. Li XR, Li ZM, Lin RC (2009) Two triterpenes from Lysimachia foenum-graecum. J Asian Nat Prod Res 11:529-533
62. Seo JB, Park SW, Choe SS, Jeong HW, Park JY, Choi EW, Seen DS, Jeong JY, Lee TG (2012) Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet. Biochem Biophys Res Commun 417(2):800-806
63. Kong C, Lee JI, Kim J, Seo Y (2011) In vitro evaluation on the antiobesity effect of lignin from the flower buds of Magnolia denudate. J Agric Food Chem 59:5665-5670
64. Martineau LC, Muhammad A, Saleem A, Hervé J, Harris CS, Arnason JT, Haddad PS (2010) Anti-adipogenic activities of Alnus incana and Populus balsamifera bark extracts, part II: bioassay-guided identification of actives salicortin and oregonin. Planta Med 76(14):1519-1524
65. Harbilas D, Vallerand D, Brault A, Saleem A, Arnason JT, Musallam L, Haddad PS (2013) Populus balsamifera extract and its active component salicortin reduce obesity and attenuate insulin resistance in a diet-induced obese mouse model. Evid Based Complement Alternat Med 2013:172537
66. Lee M, Lee SH, Kang J, Yang H, Jeong EJ, Kim HP, Kim YC, Sung SH (2013) Salicortin-derivatives from Salix pseudo-lasiogyne Twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBPα and SREBP-1c dependent pathway. Molecules 18:10484-10496
67. Jung CH, Jang SJ, Ahn J, Gwon SY, Jeon TI, Kim TW, Ha TY (2012) Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis. J Med Food 15(11):959-967
68. Choi HK, Won EK, Jang YP, Choung SY (2013) Antiobesity effect of Codonopsis lanceolata in high-calorie/high-fat-diet-induced obese rats. Evid Based Complement Alternat Med 2013:210297
69. Lee YJ, Kim DB, Lee JS, Cho JH, Kim BK, Choi HS, Lee BY, Lee OH (2013) Antioxidant activity and anti-adipogenic effects of wild herbs mainly cultivated in Korea. Molecules 18(10):12937-12950
70. Cho K, Kim SJ, Park SH, Kim S, Park T (2009) Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food 12(6):1293-1301
71. Jadeja RN, Thounaojam MC, Ramani UV, Devkar RV, Ramachandran AV (2011) Anti-obesity potential of Clerodendron glandulosum Coleb leaf aqueous extract. J Ethnopharm 135:338-343
72. Jadeja RN, Thounaojam MC, Singh TB, Devkar RV, Ramachandran AV (2012) Traditional uses, phytochemistry and pharmacology of Clerodendron glandulosum Coleb-A review. Asian Pac J Trop Med 5(1):1-6
73. Lee J, Kim D, Choi J, Choi H, Ryu JH, Jeong J, Park EJ, Kim SH, Kim S (2012) Dehydrodiconiferyl alcohol isolated from Cucurbita moschata shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. J Biol Chem 287(12):8839-8851
74. Xiao J, Wang NL, Sun B, Cai GP (2010) Estrogen receptor mediates the effects of pseudoprotodiocsin on adipogenesis in 3T3-L1 cells. Am J Physiol Cell Physiol 299(1):128-138
75. Kwon CS, Sohn HY, Kim SH, Kim JH, Son KH, Lee JS, Lim JK, Kim JS (2003) Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci Biotechnol Biochem 67(7):1451-1456
76. Jung HA, Jung HJ, Jeong HY, Kwon HJ, Kim M-S, Choi JS (2013) Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. doi: 10.1007/s12272-013-0237-9
77. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T (2001) Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med 67:628-633
78. Wang T, Wang Y, Yamashita H (2009) Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway. FEBS Lett 583:3655-3659
79. Kim MS, Kim JK, Kim HJ, Moon SR, Shin BC, Park KW, Yang HO, Kim SM, Kim KY, Park R (2003) Hibiscus extract inhibits the lipid droplet accumulation and adipogenic transcription factors expression of 3T3-L1 preadipocytes. J Altern Complement Med 9:499-504
80. Kim JY, So H, Youn M, Kim HJ, Kim Y, Park C, Kim SJ, Ha YA, Chai KY, Kim SM, Kim KY, Park R (2007) Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharm 114:260-267
81. Oben JE, Ngondi JL, Blum K (2008) Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene. Lipids Health Dis 7:44
82. Klein G, Kim J, Himmeldirk K, Cao Y, Chen X (2007) Anti-diabetes and anti-obesity activity of Lagerstroemia speciosa. Evid Based Complement Altern Med 4:401-407
83. Liu F, Kim J, Li Y, Liu X, Li J, Chen X (2001) An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr 131:2242-2247
84. Liu X, Kim J, Li Y, Li J, Liu F, Chen X (2005) Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. J Nutri 135:165-171
85. Hsieh YH, Wang SY (2013) Lucidone from Lindera erythrocarpa Makino fruits suppresses adipogenesis in 3T3-L1 cells and attenuates obesity and consequent metabolic disorders in high-fat diet C57BL/6 mice. Phytomedicine 20(5):394-400
86. Nerurkar PV, Lee YK, Nerurkar VR (2010) Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern Med 10:34
87. Hwang JT, Lee MS, Kim HJ, Sung MJ, Kim HY, Kim MS, Kwon DY (2009) Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Phytother Res 23:262-266
88. Hwang JT, Kim SH, Lee MS, Kim SH, Yang HJ, Kim MJ, Kim HS, Ha J, Kim MS, Kwon DY (2007) Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun 364(4):1002-1008
89. Gu W, Kim K, Kim DH (2013) Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. Biol Pharm Bull 36(1):102-107
90. Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N, Itoh H (2010) Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet. Biosci Biotechnol Biochem 74(3):499-503
91. Shimada T, Nagai E, Harasawa Y, Watanabe M, Negishi K, Akase T, Sai Y, Miyamoto K, Aburada M (2011) Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes. J Ethnopharm 136:67-74
92. Shimada T, Nagai E, Harasawa Y, Akase T, Aburada T, Iizuka S, Miyamoto K, Aburada M (2010) Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata. J Nat Med 64(3):266-274
93. Son Y, Nam JS, Jang MK, Jung IA, Cho SI, Jung MH (2013) Antiobesity activity of Vigna nakashimae extract in high-fat diet-induced obesity. Biosci Biotechnol Biochem 77(2):332-338
94. Kim Sh, Park HS, Lee MS, Cho YJ, Kim YS, Hwang JT, Sung MJ, Kim MS, Kwon DY (2008) Vitisin A inhibits adipocyte differentiation through cell cycle arrest in 3T3-L1 cells. Biochem Biophys Res Commun 372:108-113
95. Ogawa T, Tabata H, Katsube T, Ohta Y, Yamasaki Y, Yamasaki M, Shiwaku K (2010) Suppressive effect of hot water extract of wasabi (Wasabia japonica Matsum.) leaves on the differentiation of 3T3-L1 preadipocytes. Food Chem 118(2):239-244
96. Yamasaki M, Ogawa T, Wang L, Katsube T, Yamasaki Y, Sun X, Shiwaku K (2013) Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets. Nutr Res Pract 7(4):267-272
97. Gwon SY, Ahn JY, Kim TW, Ha TY (2012) Zanthoxylum piperitum DC ethanol extract suppresses fat accumulation in adipocytes and high fat diet-induced obese mice by regulating adipogenesis. J Nutr Sci Vitaminol 58:393-401
98. Yahagi T, Daikonya A, Kitanaka S (2012) Flavonol acylglycosides from flower of Albizia julibrissin and their inhibitory effects on lipid accumulation in 3T3-L1 cells. Chem Pharm Bull 60(1):129-136
99. Dragull K, Breksa AP 3rd, Cain B (2008) Synephrine content of juice from Satsuma mandarins (Citrus unshiu Marcovitch). J Agric Food Chem 56(19):8874-8878
100. Tsujita T, Takaku T (2007) Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark). J Nutri Sci Vitaminol 53:547-551
101. Jung HK, Jeong YS, Park CD, Park CH, Hong JH (2011) Inhibitory effect of citrus peel extract on lipid accumulation of 3T3-L1 adipocytes. J Korean Soc Appl Biol Chem 54(2):169-176
102. Takayanagi K, Morimoto S, Shirakura Y, Mukai K, Sugiyama T, Tokuji Y, Ohnishi M (2011) Mechanism of visceral fat reduction in Tsumura Suzuki obese, diabetes (TSOD) mice orally administered β-cryptoxanthin from Satsuma mandarin oranges (Citrus unshiu Marc). J Agric Food Chem 59(23):12342-12351
103. Baek J, Lee J, Kim K, Kim T, Kim D, Kim C, Tsutomu K, Ochir S, Lee K, Park HC, Lee YJ, Choe M (2013) Inhibitory effects of Capsicum annuum L. water extracts on lipoprotein lipase activity in 3T3-L1 cells. Nutr Res Pract 7(2):96-102
104. Diepvens K, Westerterp KR, Westerterp-Plantenga MS (2007) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 292(1):77-85
105. Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, Baik HW, Ha J, Park OJ (2005) Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun 338(2):694-699
106. Kawabata F, Inoue N, Yazawa S, Kawada T, Inoue K, Fushiki T (2006) Effects of CH-19 sweet, a non-pungent cultivar of red pepper, in decreasing the body weight and suppressing body fat accumulation by sympathetic nerve activation in humans. Biosci Biotechnol Biochem 70(12):2824-2835
107. Ludy MJ, Moore GE, Mattes RD (2012) The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 37(2):103-121
108. Masuda Y, Haramizu S, Oki K, Ohnuki K, Watanabe T, Yazawa S, Kawada T, Hashizume S, Fushiki T (2003) Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol 95(6):2408-2415
109. Watanabe J, Kawabata J, Kasai T (1999) 9-Oxooctadeca-10,12-dienoic Acids as Acetyl CoA Carboxylase Inhibitors from Red Pepper (Capsicum annuum L.). Biosci Biotechnol Biochem 63(3):489-493
110. Jeon G, Choi Y, Lee SM, Kim Y, Jeong HS, Lee J (2010) Anti-obesity activity of methanol extract from hot pepper (Capsicum annuum L.) seeds in 3T3-L1 adipocyte. Food Sci Biotechnol 19(4):1123-1127
111. Arumugam M, Vijayan P, Raghu C, Ashok G, Dhanaraj SA, Kumarappan CT (2008) Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1. J Complement Integr Med 5(1):1-9
112. Affuso F, Mercurio V, Fazio V, Fazio S (2010) Cardiovascular and metabolic effects of berberine. World J Cardiol 2(4):71-77
113. Kwak DH, Lee JH, Kim DG, Kim T, Lee KJ, Ma JY (2013) Inhibitory effects of Hwangryunhaedok-Tang in 3T3-L1 adipogenesis by regulation of Raf/MEK1/ERK1/2 pathway and PDK1/Akt phosphorylation. Evid Based Complement Alternat Med 2013:413906
114. Schor J (2012) Clinical applications for Berberine: Potential therapeutic applications in metabolic syndrome, type 2 diabetes, and dyslipidemia. Nat Med J. http://www.naturalmedicinejournal.com/article-content.asp?article=384
115. Cernáková M, Kostálová D (2002) Antimicrobial activity of berberine-a constituent of Mahonia aquifolium. Folia Microbiol (Praha) 47(4):375-378
116. Yu HH, Kim KJ, Cha JD, Kim HK, Lee YE, Choi NY, You YO (2005) Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food 8(4):454-461
117. Tan W, Li Y, Chen M, Wang Y (2011) Berberine hydrochloride: anti-cancer activity and nanoparticulate delivery system. Int J Nanomed 6:1773-1777
118. Choi MS, Yuk DY, Oh JH, Jung HY, Han SB, Moon DC, Hong JT (2008) Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis. Anticancer Res 28(6A):3777-3784
119. Choi MS, Oh JH, Kim SM, Jung HY, Yoo HS, Lee YM, Moon DC, Han SB, Hong JT (2009) Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. Int J Oncol 34(5):1221-1230
120. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB (2006) Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55(8):2256-2264
121. Brusq JM, Ancellin N, Grondin P, Guillard R, Martin S, Saintillan Y, Issandou M (2006) Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res 47(6):1281-1288
122. Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK, Do MS (2006) Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med 38(6):599-605
123. Hu Y, Kutscher E, Davies GE (2010) Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells. Phytother Res 24(12):1831-1838
124. Lee J, Yoon HG, Lee YH, Park J, You Y, Kim K, Jang JY, Yang JW, Jun W (2010) The potential effects of ethyl acetate fraction from Curcuma longa L. on lipolysis in differentiated 3T3-L1 adipocytes. J Med Food 13(2):364-370
125. Ejaz A, Wu D, Kwan P, Meydani M (2009) Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 139(5):919-925
126. Kim CY, Le TT, Chen C, Cheng JX, Kim KH (2011) Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion. J Nutr Biochem 10:910-920
127. Ahn J, Lee H, Kim S, Ha T (2010) Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling. Am J Physiol Cell Physiol 298(6):C1510-C1516
128. Janar J, Fang L, Wong CP, Kaneda T, Hirasawa Y, Shahmanova BG, Abduahitovich AZ, Morita H (2012) A new galloylbergenin from Bergenia crassifolia with anti-lipid droplet accumulation activity. Heterocycles 86(2):1591-1595
129. Kang SI, Shin HS, Kim HM, Hong YS, Yoon SA, Kang SW, Kim JH, Kim MH, Ko HC, Kim SJ (2012) Immature Citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice. Biol Pharm Bull 35(2):223-230
130. Sung YY, Yoon T, Yang WK, Kim SJ, Kim HK (2011) Inhibitory effects of Elsholtzia ciliata extract on fat accumulation in high-fat diet-induced obese mice. J Korean Soc Appl Biol Chem 54(3):388-394
131. Mooney MH, Fogarty S, Stevenson C, Gallagher AM, Palit P, Hawley SA, Hardie DG, Coxon GD, Waigh RD, Tate RJ, Harvey AL, Furman BL (2008) Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br J Pharmacol 153(8):1669-1677
132. Ono Y, Hattori E, Fukuya Y, Imai S, Ohzumi Y (2006) Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharm 106:238-244
133. Du H, You JS, Zhao X, Park JY, Kim SH, Chang KJ (2010) Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci 17(Suppl 1):S42
134. Seigner R, Heuser S, Holtzmann U, Söhle J, Schepky T, Raschke F, Stäb H, Wenck H, Winnefeld M (2010) Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle. Nutr Metabol 7:66
135. Ahn JH, Kim ES, Lee C, Kim S, Cho SH, Hwang BY, Lee MK (2013) Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects. Bioorg Med Chem Lett 23(12):3604-3608
136. You JS, Lee YJ, Kim KS, Kim SH, Chang KJ (2014) Anti-obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre-adipocytes and rats fed a high-fat diet. J Sci Food Agri 94(3):568-575
137. Roh C, Jung U (2012) Nepeta japonica Maximowicz extract from natural products inhibits lipid accumulation. J Sci Food Agri 92(10):2195-2199
138. Nukitrangsan N, Okabe T, Toda T, Inafuku M, Iwasaki H, Yanagita T, Oku H (2011) Effect of Peucedanum japonicum Thunb on the expression of obesity-related genes in mice on a high-fat diet. J Oleo Sci 60(10):527-536
139. Okabe T, Toda T, Nukitrangsan N, Inafuku M, Iwasaki H, Oku H (2011) Peucedanum japonicum Thunb inhibits high-fat diet induced obesity in mice. Phytother Res 6:870-877
140. Nukitrangsan N, Okabe T, Toda T, Inafuku M, Iwasaki H, Oku H (2012) Effect of Peucedanum japonicum Thunb extract on high-fat diet-induced obesity and gene expression in mice. J Oleo Sci 61(2):89-101
141. Nugara RN, Inafuku M, Iwasaki H, Oku H (2013) Partially purified Peucedanum japonicum Thunb extracts exert anti-obesity effects in vitro. Nutrition. doi: 10.1016/j.nut.2013.09.017
142. Kang SI, Shin HS, Kim HM, Hong YS, Yoon SA, Kang SW, Kim JH, Ko HC, Kim SJ (2012) Anti-obesity properties of a Sasa quelpaertensis extract in high-fat diet-induced obese mice. Biosci Biotechnol Biochem 76(4):755-761
143. Kang SW, Kang SI, Shin HS, Yoon SA, Kim JH, Ko HC, Kim SJ (2013) Sasa quelpaertensis Nakai extract and its constituent p-coumaric acid inhibit adipogenesis in 3T3-L1 cells through activation of the AMPK pathway. Food Chem Toxicol 59:380-385
144. Kim JH, Kang SI, Shin HS, Yoon SA, Kang SW, Ko HC, Kim SJ (2013) Sasa quelpaertensis and p-coumaric acid attenuate oleic acid-induced lipid accumulation in HepG2 cells. Biosci Biotechnol Biochem 77(7):1595-1598
145. Yoon SA, Kang SI, Shin HS, Kang SW, Kim JH, Ko HC, Kim SJ (2013) p-Coumaric acid modulates glucose and lipid metabolism via AMP-activated protein kinase in L6 skeletal muscle cells. Biochem Biophys Res Commun 432(4):553-557
146. Iwashita K, Yamaki K, Tsushida T (2001) Mioga (Zingiber mioga Rosc.) extract prevents 3T3-L1 differentiation into adipocytes and obesity in mice. Food Sci Technol Res 7(2):164-170