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Volumn 48, Issue 12, 2007, Pages 2547-2559

The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis

Author keywords

Adipocyte; Adipophilin; Adipose differentiation related protein; Adipose triglyceride lipase; cAMP dependent; Hormone sensitive lipase; Protein kinase; TIP47; Triacylglycerol

Indexed keywords

ADIPOPHILIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAT DROPLET; MEMBRANE PROTEIN; PERILIPIN; PROTEIN MLDP; PROTEIN OXPAT; PROTEIN S3 12; PROTEIN TIP47; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PHOSPHOPROTEIN; TRIACYLGLYCEROL LIPASE;

EID: 36649015243     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R700014-JLR200     Document Type: Review
Times cited : (810)

References (148)
  • 1
    • 0016612281 scopus 로고
    • Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts
    • Brown, M. S., J. R. Faust, and J. L. Goldstein. 1975. Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. J. Clin. Invest. 55: 783-793.
    • (1975) J. Clin. Invest , vol.55 , pp. 783-793
    • Brown, M.S.1    Faust, J.R.2    Goldstein, J.L.3
  • 2
    • 0017239547 scopus 로고
    • Receptor-mediated control of cholesterol metabolism
    • Brown, M. S., and J. L. Goldstein. 1976. Receptor-mediated control of cholesterol metabolism. Science. 191: 150-154.
    • (1976) Science , vol.191 , pp. 150-154
    • Brown, M.S.1    Goldstein, J.L.2
  • 3
    • 0016303130 scopus 로고
    • Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia
    • Goldstein, J. L., S. E. Dana, and M. S. Brown. 1974. Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. Proc. Natl. Acad. Sci. USA. 71: 4288-4292.
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 4288-4292
    • Goldstein, J.L.1    Dana, S.E.2    Brown, M.S.3
  • 4
    • 0025772167 scopus 로고
    • Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
    • Greenberg, A. S., J. J. Egan, S. A. Wek, N. B. Garty, E. J. Blanchette-Mackie, and C. Londos. 1991. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266: 11341-11346.
    • (1991) J. Biol. Chem , vol.266 , pp. 11341-11346
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3    Garty, N.B.4    Blanchette-Mackie, E.J.5    Londos, C.6
  • 5
    • 8744267532 scopus 로고    scopus 로고
    • Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes
    • Brasaemle, D. L., G. Dolios, L. Shapiro, and R. Wang. 2004. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 279: 46835-46842.
    • (2004) J. Biol. Chem , vol.279 , pp. 46835-46842
    • Brasaemle, D.L.1    Dolios, G.2    Shapiro, L.3    Wang, R.4
  • 6
    • 1642565185 scopus 로고    scopus 로고
    • Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7
    • Fujimoto, Y., H. Itabe, J. Sakai, M. Makita, J. Noda, M. Mori, Y. Higashi, S. Kojima, and T. Takano. 2004. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim. Biophys. Acta. 1644: 47-59.
    • (2004) Biochim. Biophys. Acta , vol.1644 , pp. 47-59
    • Fujimoto, Y.1    Itabe, H.2    Sakai, J.3    Makita, M.4    Noda, J.5    Mori, M.6    Higashi, Y.7    Kojima, S.8    Takano, T.9
  • 7
    • 0942287191 scopus 로고    scopus 로고
    • Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic
    • Liu, P., Y. Ying, Y. Zhao, D. I. Mundy, M. Zhu, and R. G. Anderson. 2004. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J. Biol. Chem. 279: 3787-3792.
    • (2004) J. Biol. Chem , vol.279 , pp. 3787-3792
    • Liu, P.1    Ying, Y.2    Zhao, Y.3    Mundy, D.I.4    Zhu, M.5    Anderson, R.G.6
  • 8
    • 33746959419 scopus 로고    scopus 로고
    • Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets
    • Turro, S., M. Ingelmo-Torres, J. M. Estanyol, F. Tebar, M. A. Fernandez, C. V. Albor, K. Gaus, T. Grewal, C. Enrich, and A. Pol. 2006. Identification and characterization of associated with lipid droplet protein 1: a novel membrane-associated protein that resides on hepatic lipid droplets. Traffic. 7: 1254-1269.
    • (2006) Traffic , vol.7 , pp. 1254-1269
    • Turro, S.1    Ingelmo-Torres, M.2    Estanyol, J.M.3    Tebar, F.4    Fernandez, M.A.5    Albor, C.V.6    Gaus, K.7    Grewal, T.8    Enrich, C.9    Pol, A.10
  • 10
    • 0033769564 scopus 로고    scopus 로고
    • Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells
    • Wu, C. C., K. E. Howell, M. C. Neville, J. R. Yates, III, and J. L. McManaman. 2000. Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells. Electrophoresis. 21: 3470-3482.
    • (2000) Electrophoresis , vol.21 , pp. 3470-3482
    • Wu, C.C.1    Howell, K.E.2    Neville, M.C.3    Yates III, J.R.4    McManaman, J.L.5
  • 11
    • 33644668609 scopus 로고    scopus 로고
    • Cell biology. Great balls of fat
    • Beckman, M. 2006. Cell biology. Great balls of fat. Science. 311: 1232-1234.
    • (2006) Science , vol.311 , pp. 1232-1234
    • Beckman, M.1
  • 12
    • 0024987957 scopus 로고
    • Oleosin KD 18 on the surface of oil bodies in maize. Genomic and cDNA sequences and the deduced protein structure
    • Qu, R. D., and A. H. Huang. 1990. Oleosin KD 18 on the surface of oil bodies in maize. Genomic and cDNA sequences and the deduced protein structure. J. Biol. Chem. 265: 2238-2243.
    • (1990) J. Biol. Chem , vol.265 , pp. 2238-2243
    • Qu, R.D.1    Huang, A.H.2
  • 13
    • 16544370489 scopus 로고    scopus 로고
    • Endoplasmic reticulum, oleosins, and oils in seeds and tapetum cells
    • Hsieh, K., and A. H. Huang. 2004. Endoplasmic reticulum, oleosins, and oils in seeds and tapetum cells. Plant Physiol. 136: 3427-3434.
    • (2004) Plant Physiol , vol.136 , pp. 3427-3434
    • Hsieh, K.1    Huang, A.H.2
  • 14
    • 33947206157 scopus 로고    scopus 로고
    • Synthesis, storage and degradation of neutral lipids in yeast
    • Czabany, T., K. Athenstaedt, and G. Daum. 2007. Synthesis, storage and degradation of neutral lipids in yeast. Biochim. Biophys. Acta. 1771: 299-309.
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 299-309
    • Czabany, T.1    Athenstaedt, K.2    Daum, G.3
  • 17
    • 0020464381 scopus 로고
    • Studies on the source of cholesterol used for steroid biosynthesis in cultured Leydig tumor cells
    • Freeman, D. A., and M. Ascoli. 1982. Studies on the source of cholesterol used for steroid biosynthesis in cultured Leydig tumor cells. J. Biol. Chem. 257: 14231-14238.
    • (1982) J. Biol. Chem , vol.257 , pp. 14231-14238
    • Freeman, D.A.1    Ascoli, M.2
  • 18
    • 0020150042 scopus 로고
    • The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands
    • Gwynne, J. T., and J. F. Strauss, III. 1982. The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr. Rev. 3: 299-329.
    • (1982) Endocr. Rev , vol.3 , pp. 299-329
    • Gwynne, J.T.1    Strauss III, J.F.2
  • 19
    • 0025298046 scopus 로고
    • Effect of cholesterol transport inhibitors on steroidogenesis and plasma membrane cholesterol transport in cultured MA-10 Leydig tumor cells
    • Nagy, L., and D. A. Freeman. 1990. Effect of cholesterol transport inhibitors on steroidogenesis and plasma membrane cholesterol transport in cultured MA-10 Leydig tumor cells. Endocrinology. 126: 2267-2276.
    • (1990) Endocrinology , vol.126 , pp. 2267-2276
    • Nagy, L.1    Freeman, D.A.2
  • 20
    • 0842301109 scopus 로고    scopus 로고
    • Structure and function of hepatic stellate cells
    • Senoo, H. 2004. Structure and function of hepatic stellate cells. Med. Electron Microsc. 37: 3-15.
    • (2004) Med. Electron Microsc , vol.37 , pp. 3-15
    • Senoo, H.1
  • 21
    • 0030901258 scopus 로고    scopus 로고
    • The pulmonary lipofibroblast (lipid interstitial cell) and its contributions to alveolar development
    • McGowan, S. E., and J. S. Torday. 1997. The pulmonary lipofibroblast (lipid interstitial cell) and its contributions to alveolar development. Annu. Rev. Physiol. 59: 43-62.
    • (1997) Annu. Rev. Physiol , vol.59 , pp. 43-62
    • McGowan, S.E.1    Torday, J.S.2
  • 22
    • 33845316798 scopus 로고    scopus 로고
    • Secretion and fluid transport mechanisms in the mammary gland: Comparisons with the exocrine pancreas and the salivary gland
    • McManaman, J. L., M. E. Reyland, and E. C. Thrower. 2006. Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. J. Mammary Gland Biol. Neoplasia. 11: 249-268.
    • (2006) J. Mammary Gland Biol. Neoplasia , vol.11 , pp. 249-268
    • McManaman, J.L.1    Reyland, M.E.2    Thrower, E.C.3
  • 23
    • 33845740182 scopus 로고    scopus 로고
    • Leukocyte lipid bodies regulation and function: Contribution to allergy and host defense
    • Bozza, P. T., R. C. Melo, and C. Bandeira-Melo. 2007. Leukocyte lipid bodies regulation and function: contribution to allergy and host defense. Pharmacol. Ther. 113: 30-49.
    • (2007) Pharmacol. Ther , vol.113 , pp. 30-49
    • Bozza, P.T.1    Melo, R.C.2    Bandeira-Melo, C.3
  • 25
    • 0037113954 scopus 로고    scopus 로고
    • The surface of lipid droplets is a phospholipidmonolayer with a unique fatty acid composition
    • Tauchi-Sato, K., S. Ozeki, T. Houjou, R. Taguchi, and T. Fujimoto. 2002. The surface of lipid droplets is a phospholipidmonolayer with a unique fatty acid composition. J. Biol. Chem. 277: 44507-44512.
    • (2002) J. Biol. Chem , vol.277 , pp. 44507-44512
    • Tauchi-Sato, K.1    Ozeki, S.2    Houjou, T.3    Taguchi, R.4    Fujimoto, T.5
  • 26
    • 0030724392 scopus 로고    scopus 로고
    • Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
    • Brasaemle, D. L., T. Barber, N. E. Wolins, G. Serrero, E. J. Blanchette-Mackie, and C. Londos. 1997. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38: 2249-2263.
    • (1997) J. Lipid Res , vol.38 , pp. 2249-2263
    • Brasaemle, D.L.1    Barber, T.2    Wolins, N.E.3    Serrero, G.4    Blanchette-Mackie, E.J.5    Londos, C.6
  • 27
    • 0031733596 scopus 로고    scopus 로고
    • Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases
    • Heid, H. W., R. Moll, I. Schwetlick, H. R. Rackwitz, and T. W. Keenan. 1998. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 294: 309-321.
    • (1998) Cell Tissue Res , vol.294 , pp. 309-321
    • Heid, H.W.1    Moll, R.2    Schwetlick, I.3    Rackwitz, H.R.4    Keenan, T.W.5
  • 28
    • 0032076636 scopus 로고    scopus 로고
    • TIP47: A cargo selection device for mannose 6-phosphate receptor trafficking
    • Diaz, E., and S. R. Pfeffer. 1998. TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell. 93: 433-443.
    • (1998) Cell , vol.93 , pp. 433-443
    • Diaz, E.1    Pfeffer, S.R.2
  • 29
    • 0037200026 scopus 로고    scopus 로고
    • Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium
    • Miura, S., J. W. Gan, J. Brzostowski, M. J. Parisi, C. J. Schultz, C. Londos, B. Oliver, and A. R. Kimmel. 2002. Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J. Biol. Chem. 277: 32253-32257.
    • (2002) J. Biol. Chem , vol.277 , pp. 32253-32257
    • Miura, S.1    Gan, J.W.2    Brzostowski, J.3    Parisi, M.J.4    Schultz, C.J.5    Londos, C.6    Oliver, B.7    Kimmel, A.R.8
  • 30
    • 0035895982 scopus 로고    scopus 로고
    • TIP47 associates with lipid droplets
    • Wolins, N. E., B. Rubin, and D. L. Brasaemle. 2001. TIP47 associates with lipid droplets. J. Biol. Chem. 276: 5101-5108.
    • (2001) J. Biol. Chem , vol.276 , pp. 5101-5108
    • Wolins, N.E.1    Rubin, B.2    Brasaemle, D.L.3
  • 31
    • 0037352729 scopus 로고    scopus 로고
    • Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells
    • Than, N. G., B. Sumegi, S. Bellyei, T. Berki, G. Szekeres, T. Janaky, A. Szigeti, H. Bohn, and G. N. Than. 2003. Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells. Eur. J. Biochem. 270: 1176-1188.
    • (2003) Eur. J. Biochem , vol.270 , pp. 1176-1188
    • Than, N.G.1    Sumegi, B.2    Bellyei, S.3    Berki, T.4    Szekeres, G.5    Janaky, T.6    Szigeti, A.7    Bohn, H.8    Than, G.N.9
  • 33
    • 3142640798 scopus 로고    scopus 로고
    • Structure of a lipid droplet protein: The PAT family member TIP47
    • Hickenbottom, S. J., A. R. Kimmel, C. Londos, and J. H. Hurley. 2004. Structure of a lipid droplet protein: the PAT family member TIP47. Structure. 12: 1199-1207.
    • (2004) Structure , vol.12 , pp. 1199-1207
    • Hickenbottom, S.J.1    Kimmel, A.R.2    Londos, C.3    Hurley, J.H.4
  • 35
    • 3242656580 scopus 로고    scopus 로고
    • Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins
    • Saito, H., S. Lund-Katz, and M. C. Phillips. 2004. Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. Prog. Lipid Res. 43: 350-380.
    • (2004) Prog. Lipid Res , vol.43 , pp. 350-380
    • Saito, H.1    Lund-Katz, S.2    Phillips, M.C.3
  • 36
    • 33749058310 scopus 로고    scopus 로고
    • A proposed model of fat packaging by exchangeable lipid droplet proteins
    • Wolins, N. E., D. L. Brasaemle, and P. E. Bickel. 2006. A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett. 580: 5484-5491.
    • (2006) FEBS Lett , vol.580 , pp. 5484-5491
    • Wolins, N.E.1    Brasaemle, D.L.2    Bickel, P.E.3
  • 37
    • 31444438260 scopus 로고    scopus 로고
    • Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: Stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin
    • Gross, D. N., H. Miyoshi, T. Hosaka, H. H. Zhang, E. C. Pino, S. Souza, M. Obin, A. S. Greenberg, and P. F. Pilch. 2006. Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin. Mol. Endocrinol. 20: 459-466.
    • (2006) Mol. Endocrinol , vol.20 , pp. 459-466
    • Gross, D.N.1    Miyoshi, H.2    Hosaka, T.3    Zhang, H.H.4    Pino, E.C.5    Souza, S.6    Obin, M.7    Greenberg, A.S.8    Pilch, P.F.9
  • 39
    • 30044445455 scopus 로고    scopus 로고
    • Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway
    • Xu, G., C. Sztalryd, X. Lu, J. T. Tansey, J. Gan, H. Dorward, A. R. Kimmel, and C. Londos. 2005. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J. Biol. Chem. 280: 42841-42847.
    • (2005) J. Biol. Chem , vol.280 , pp. 42841-42847
    • Xu, G.1    Sztalryd, C.2    Lu, X.3    Tansey, J.T.4    Gan, J.5    Dorward, H.6    Kimmel, A.R.7    Londos, C.8
  • 40
    • 33745751795 scopus 로고    scopus 로고
    • Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft
    • Ohsaki, Y., T. Maeda, M. Maeda, K. Tauchi-Sato, and T. Fujimoto. 2006. Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft. Biochem. Biophys. Res. Commun. 347: 279-287.
    • (2006) Biochem. Biophys. Res. Commun , vol.347 , pp. 279-287
    • Ohsaki, Y.1    Maeda, T.2    Maeda, M.3    Tauchi-Sato, K.4    Fujimoto, T.5
  • 42
    • 0038546739 scopus 로고    scopus 로고
    • Adipose differentiation-related protein has two independent domains for targeting to lipid droplets
    • Nakamura, N., and T. Fujimoto. 2003. Adipose differentiation-related protein has two independent domains for targeting to lipid droplets. Biochem. Biophys. Res. Commun. 306: 333-338.
    • (2003) Biochem. Biophys. Res. Commun , vol.306 , pp. 333-338
    • Nakamura, N.1    Fujimoto, T.2
  • 43
    • 0037903214 scopus 로고    scopus 로고
    • Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein
    • Targett-Adams, P., D. Chambers, S. Gledhill, R. G. Hope, J. F. Coy, A. Girod, and J. McLauchlan. 2003. Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. J. Biol. Chem. 278: 15998-16007.
    • (2003) J. Biol. Chem , vol.278 , pp. 15998-16007
    • Targett-Adams, P.1    Chambers, D.2    Gledhill, S.3    Hope, R.G.4    Coy, J.F.5    Girod, A.6    McLauchlan, J.7
  • 44
    • 0032401636 scopus 로고    scopus 로고
    • Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants
    • Than, N. G., B. Sumegi, G. N. Than, G. Kispal, and H. Bohn. 1998. Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. Eur. J. Biochem. 258: 752-757.
    • (1998) Eur. J. Biochem , vol.258 , pp. 752-757
    • Than, N.G.1    Sumegi, B.2    Than, G.N.3    Kispal, G.4    Bohn, H.5
  • 46
    • 33744913055 scopus 로고    scopus 로고
    • MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha
    • Yamaguchi, T., S. Matsushita, K. Motojima, F. Hirose, and T. Osumi. 2006. MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 281: 14232-14240.
    • (2006) J. Biol. Chem , vol.281 , pp. 14232-14240
    • Yamaguchi, T.1    Matsushita, S.2    Motojima, K.3    Hirose, F.4    Osumi, T.5
  • 48
    • 0031810251 scopus 로고    scopus 로고
    • Cloning of cell-specific secreted and surface proteins by subtractive antibody screening
    • Scherer, P. E., P. E. Bickel, M. Kotler, and H. F. Lodish. 1998. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat. Biotechnol. 16: 581-586.
    • (1998) Nat. Biotechnol , vol.16 , pp. 581-586
    • Scherer, P.E.1    Bickel, P.E.2    Kotler, M.3    Lodish, H.F.4
  • 50
    • 0027145164 scopus 로고
    • Isolation of cDNAs for perilipins A and B: Sequence and expression of lipid droplet-associated proteins of adipocytes
    • Greenberg, A. S., J. J. Egan, S. A. Wek, M. C. Moos, Jr., C. Londos, and A. R. Kimmel. 1993. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc. Natl. Acad. Sci. USA. 90: 12035-12039.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 12035-12039
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3    Moos Jr., M.C.4    Londos, C.5    Kimmel, A.R.6
  • 53
    • 0028998905 scopus 로고
    • Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells
    • Servetnick, D. A., D. L. Brasaemle, J. Gruia-Gray, A. R. Kimmel, J. Wolff, and C. Londos. 1995. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells. J. Biol. Chem. 270: 16970-16973.
    • (1995) J. Biol. Chem , vol.270 , pp. 16970-16973
    • Servetnick, D.A.1    Brasaemle, D.L.2    Gruia-Gray, J.3    Kimmel, A.R.4    Wolff, J.5    Londos, C.6
  • 54
    • 0037414820 scopus 로고    scopus 로고
    • The central domain is required to target and anchor perilipin A to lipid droplets
    • Garcia, A., A. Sekowski, V. Subramanian, and D. L. Brasaemle. 2003. The central domain is required to target and anchor perilipin A to lipid droplets. J. Biol. Chem. 278: 625-635.
    • (2003) J. Biol. Chem , vol.278 , pp. 625-635
    • Garcia, A.1    Sekowski, A.2    Subramanian, V.3    Brasaemle, D.L.4
  • 55
    • 0347065339 scopus 로고    scopus 로고
    • Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis
    • Zhang, H. H., S. C. Souza, K. V. Muliro, F. B. Kraemer, M. S. Obin, and A. S. Greenberg. 2003. Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J. Biol. Chem. 278: 51535-51542.
    • (2003) J. Biol. Chem , vol.278 , pp. 51535-51542
    • Zhang, H.H.1    Souza, S.C.2    Muliro, K.V.3    Kraemer, F.B.4    Obin, M.S.5    Greenberg, A.S.6
  • 56
    • 20544457076 scopus 로고    scopus 로고
    • Hydrophobic sequences target and anchor perilipin A to lipid droplets
    • Subramanian, V., A. Garcia, A. Sekowski, and D. L. Brasaemle. 2004. Hydrophobic sequences target and anchor perilipin A to lipid droplets. J. Lipid Res. 45: 1983-1991.
    • (2004) J. Lipid Res , vol.45 , pp. 1983-1991
    • Subramanian, V.1    Garcia, A.2    Sekowski, A.3    Brasaemle, D.L.4
  • 57
    • 34547581106 scopus 로고    scopus 로고
    • Regulation of adipocyte lipolysis by degradation of the perilipin protein: Nelfinavir enhances lysosome-mediated perilipin proteolysis
    • Kovsan, J., R. Ben-Romano, S. C. Souza, A. S. Greenberg, and A. Rudich. 2007. Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis. J. Biol. Chem. 282: 21704-21711.
    • (2007) J. Biol. Chem , vol.282 , pp. 21704-21711
    • Kovsan, J.1    Ben-Romano, R.2    Souza, S.C.3    Greenberg, A.S.4    Rudich, A.5
  • 58
    • 0034861995 scopus 로고    scopus 로고
    • The murine perilipin gene: The lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin
    • Lu, X., J. Gruia-Gray, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, C. Londos, and A. R. Kimmel. 2001. The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin. Mamm. Genome. 12: 741-749.
    • (2001) Mamm. Genome , vol.12 , pp. 741-749
    • Lu, X.1    Gruia-Gray, J.2    Copeland, N.G.3    Gilbert, D.J.4    Jenkins, N.A.5    Londos, C.6    Kimmel, A.R.7
  • 59
    • 0032033182 scopus 로고    scopus 로고
    • Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method
    • Nishiu, J., T. Tanaka, and Y. Nakamura. 1998. Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. Genomics. 48: 254-257.
    • (1998) Genomics , vol.48 , pp. 254-257
    • Nishiu, J.1    Tanaka, T.2    Nakamura, Y.3
  • 60
    • 0038054286 scopus 로고    scopus 로고
    • A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins
    • Bussell, R., Jr., and D. Eliezer. 2003. A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins. J. Mol. Biol. 329: 763-778.
    • (2003) J. Mol. Biol , vol.329 , pp. 763-778
    • Bussell Jr., R.1    Eliezer, D.2
  • 61
    • 15244347219 scopus 로고    scopus 로고
    • Helix periodicity, topology, and dynamics of membrane-associated alphasynuclein
    • Bussell, R., Jr., T. F. Ramlall, and D. Eliezer. 2005. Helix periodicity, topology, and dynamics of membrane-associated alphasynuclein. Protein Sci. 14: 862-872.
    • (2005) Protein Sci , vol.14 , pp. 862-872
    • Bussell Jr., R.1    Ramlall, T.F.2    Eliezer, D.3
  • 62
    • 0037155197 scopus 로고    scopus 로고
    • Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alphasynuclein
    • Cole, N. B., D. D. Murphy, T. Grider, S. Rueter, D. Brasaemle, and R. L. Nussbaum. 2002. Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alphasynuclein. J. Biol. Chem. 277: 6344-6352.
    • (2002) J. Biol. Chem , vol.277 , pp. 6344-6352
    • Cole, N.B.1    Murphy, D.D.2    Grider, T.3    Rueter, S.4    Brasaemle, D.5    Nussbaum, R.L.6
  • 64
    • 34147158237 scopus 로고    scopus 로고
    • Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: Many ways to skin ACAT or a DGAT
    • Turkish, A., and S. L. Sturley. 2007. Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: many ways to skin ACAT or a DGAT. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G953-G957.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol , vol.292
    • Turkish, A.1    Sturley, S.L.2
  • 65
    • 33751161853 scopus 로고    scopus 로고
    • Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis
    • Robenek, H., O. Hofnagel, I. Buers, M. J. Robenek, D. Troyer, and N. J. Severs. 2006. Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis. J. Cell Sci. 119: 4215-4224.
    • (2006) J. Cell Sci , vol.119 , pp. 4215-4224
    • Robenek, H.1    Hofnagel, O.2    Buers, I.3    Robenek, M.J.4    Troyer, D.5    Severs, N.J.6
  • 66
    • 0019303464 scopus 로고
    • Transport of lipid across capillary endothelium
    • Scow, R. O., E. J. Blanchette-Mackie, and L. C. Smith. 1980. Transport of lipid across capillary endothelium. Fed. Proc. 39: 2610-2617.
    • (1980) Fed. Proc , vol.39 , pp. 2610-2617
    • Scow, R.O.1    Blanchette-Mackie, E.J.2    Smith, L.C.3
  • 68
    • 0034611001 scopus 로고    scopus 로고
    • Dynein-mediated cargo transport in vivo. A switch controls travel distance
    • Gross, S. P., M. A. Welte, S. M. Block, and E. F. Wieschaus. 2000. Dynein-mediated cargo transport in vivo. A switch controls travel distance. J. Cell Biol. 148: 945-956.
    • (2000) J. Cell Biol , vol.148 , pp. 945-956
    • Gross, S.P.1    Welte, M.A.2    Block, S.M.3    Wieschaus, E.F.4
  • 69
    • 0032756658 scopus 로고    scopus 로고
    • Role of dynactin in endocytic traffic: Effects of dynamitin overexpression and colocalization with CLIP-170
    • Valetti, C., D. M. Wetzel, M. Schrader, M. J. Hasbani, S. R. Gill, T. E. Kreis, and T. A. Schroer. 1999. Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170. Mol. Biol. Cell. 10: 4107-4120.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 4107-4120
    • Valetti, C.1    Wetzel, D.M.2    Schrader, M.3    Hasbani, M.J.4    Gill, S.R.5    Kreis, T.E.6    Schroer, T.A.7
  • 70
    • 0032548920 scopus 로고    scopus 로고
    • Developmental regulation of vesicle transport in Drosophila embryos: Forces and kinetics
    • Welte, M. A., S. P. Gross, M. Postner, S. M. Block, and E. F. Wieschaus. 1998. Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics. Cell. 92: 547-557.
    • (1998) Cell , vol.92 , pp. 547-557
    • Welte, M.A.1    Gross, S.P.2    Postner, M.3    Block, S.M.4    Wieschaus, E.F.5
  • 71
    • 4143104547 scopus 로고    scopus 로고
    • Seeing the trees in the forest: Selective electroporation of adipocytes within adipose tissue
    • Granneman, J. G., P. Li, Y. Lu, and J. Tilak. 2004. Seeing the trees in the forest: selective electroporation of adipocytes within adipose tissue. Am. J. Physiol. Endocrinol. Metab. 287: E574-E582.
    • (2004) Am. J. Physiol. Endocrinol. Metab , vol.287
    • Granneman, J.G.1    Li, P.2    Lu, Y.3    Tilak, J.4
  • 72
    • 33744904687 scopus 로고    scopus 로고
    • The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion
    • Marcinkiewicz, A., D. Gauthier, A. Garcia, and D. L. Brasaemle. 2006. The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion. J. Biol. Chem. 281: 11901-11909.
    • (2006) J. Biol. Chem , vol.281 , pp. 11901-11909
    • Marcinkiewicz, A.1    Gauthier, D.2    Garcia, A.3    Brasaemle, D.L.4
  • 73
    • 34248189053 scopus 로고    scopus 로고
    • CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation
    • Yamaguchi, T., N. Omatsu, E. Morimoto, H. Nakashima, K. Ueno, T. Tanaka, K. Satouchi, F. Hirose, and T. Osumi. 2007. CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation. J. Lipid Res. 48: 1078-1089.
    • (2007) J. Lipid Res , vol.48 , pp. 1078-1089
    • Yamaguchi, T.1    Omatsu, N.2    Morimoto, E.3    Nakashima, H.4    Ueno, K.5    Tanaka, T.6    Satouchi, K.7    Hirose, F.8    Osumi, T.9
  • 75
    • 0023653510 scopus 로고
    • Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue
    • Holm, C., P. Belfrage, and G. Fredrikson. 1987. Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue. Biochem. Biophys. Res. Commun. 148: 99-105.
    • (1987) Biochem. Biophys. Res. Commun , vol.148 , pp. 99-105
    • Holm, C.1    Belfrage, P.2    Fredrikson, G.3
  • 77
    • 0019812097 scopus 로고
    • Hormone-sensitive cholesterol ester hydrolase of bovine adrenal cortex: Identification of the enzyme protein
    • Cook, K. G., F. T. Lee, and S. J. Yeaman. 1981. Hormone-sensitive cholesterol ester hydrolase of bovine adrenal cortex: identification of the enzyme protein. FEBS Lett. 132: 10-14.
    • (1981) FEBS Lett , vol.132 , pp. 10-14
    • Cook, K.G.1    Lee, F.T.2    Yeaman, S.J.3
  • 78
    • 0019481108 scopus 로고
    • Hormone-sensitive lipase of rat adipose tissue. Purification and some properties
    • Fredrikson, G., P. Stralfors, N. O. Nilsson, and P. Belfrage. 1981. Hormone-sensitive lipase of rat adipose tissue. Purification and some properties. J. Biol. Chem. 256: 6311-6320.
    • (1981) J. Biol. Chem , vol.256 , pp. 6311-6320
    • Fredrikson, G.1    Stralfors, P.2    Nilsson, N.O.3    Belfrage, P.4
  • 79
    • 0016833407 scopus 로고
    • Cholesterol esterase in rat adipose tissue and its activation by cyclic adenosine 3′:5′-monophosphate-dependent protein kinase
    • Pittman, R. C., J. C. Khoo, and D. Steinberg. 1975. Cholesterol esterase in rat adipose tissue and its activation by cyclic adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem. 250: 4505-4511.
    • (1975) J. Biol. Chem , vol.250 , pp. 4505-4511
    • Pittman, R.C.1    Khoo, J.C.2    Steinberg, D.3
  • 81
    • 1842414968 scopus 로고
    • Effect of epinephrine on glucose uptake and glycerol release by adipose tissue in vitro
    • Leboeuf, B., R. B. Flinn, and G. F. Cahill, Jr. 1959. Effect of epinephrine on glucose uptake and glycerol release by adipose tissue in vitro. Proc. Soc. Exp. Biol. Med. 102: 527-529.
    • (1959) Proc. Soc. Exp. Biol. Med , vol.102 , pp. 527-529
    • Leboeuf, B.1    Flinn, R.B.2    Cahill Jr., G.F.3
  • 82
    • 78651160857 scopus 로고
    • Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine 3′,5′-phosphate
    • Rizack, M. A. 1964. Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine 3′,5′-phosphate. J. Biol. Chem. 239: 392-395.
    • (1964) J. Biol. Chem , vol.239 , pp. 392-395
    • Rizack, M.A.1
  • 83
    • 0035787319 scopus 로고    scopus 로고
    • The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
    • Collins, S., and R. S. Surwit. 2001. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog. Horm. Res. 56: 309-328.
    • (2001) Recent Prog. Horm. Res , vol.56 , pp. 309-328
    • Collins, S.1    Surwit, R.S.2
  • 84
    • 4544357340 scopus 로고    scopus 로고
    • Learning new tricks from old dogs: Beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    • Collins, S., W. Cao, and J. Robidoux. 2004. Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol. Endocrinol. 18: 2123-2131.
    • (2004) Mol. Endocrinol , vol.18 , pp. 2123-2131
    • Collins, S.1    Cao, W.2    Robidoux, J.3
  • 85
    • 33646778517 scopus 로고    scopus 로고
    • Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome
    • Langin, D. 2006. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol. Res. 53: 482-491.
    • (2006) Pharmacol. Res , vol.53 , pp. 482-491
    • Langin, D.1
  • 87
    • 0018823246 scopus 로고
    • Regulation of adipose tissue lipolysis: Phosphorylation of hormone sensitive lipase in intact rat adipocytes
    • Belfrage, P., G. Fredrikson, N. O. Nilsson, and P. Stralfors. 1980. Regulation of adipose tissue lipolysis: phosphorylation of hormone sensitive lipase in intact rat adipocytes. FEBS Lett. 111: 120-124.
    • (1980) FEBS Lett , vol.111 , pp. 120-124
    • Belfrage, P.1    Fredrikson, G.2    Nilsson, N.O.3    Stralfors, P.4
  • 88
    • 0019847943 scopus 로고
    • Regulation of adipose-tissue lipolysis by phosphorylation of hormone-sensitive lipase
    • Belfrage, P., G. Fredrikson, N. O. Nilsson, and P. Stralfors. 1981. Regulation of adipose-tissue lipolysis by phosphorylation of hormone-sensitive lipase. Int. J. Obes. 5: 635-641.
    • (1981) Int. J. Obes , vol.5 , pp. 635-641
    • Belfrage, P.1    Fredrikson, G.2    Nilsson, N.O.3    Stralfors, P.4
  • 89
    • 0742311675 scopus 로고
    • Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase
    • Kawamura, M., D. F. Jensen, E. V. Wancewicz, L. L. Joy, J. C. Khoo, and D. Steinberg. 1981. Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA. 78: 732-736.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 732-736
    • Kawamura, M.1    Jensen, D.F.2    Wancewicz, E.V.3    Joy, L.L.4    Khoo, J.C.5    Steinberg, D.6
  • 90
    • 0015919843 scopus 로고
    • Hormonal regulation of adipocyte enzymes. The effects of epinephrine and insulin on the control of lipase, phosphorylase kinase, phosphorylase, and glycogen synthase
    • Khoo, J. C., D. Steinberg, B. Thompson, and S. E. Mayer. 1973. Hormonal regulation of adipocyte enzymes. The effects of epinephrine and insulin on the control of lipase, phosphorylase kinase, phosphorylase, and glycogen synthase. J. Biol. Chem. 248: 3823-3830.
    • (1973) J. Biol. Chem , vol.248 , pp. 3823-3830
    • Khoo, J.C.1    Steinberg, D.2    Thompson, B.3    Mayer, S.E.4
  • 91
    • 0016372834 scopus 로고
    • The mechanism of activation of hormone-sensitive lipase in human adipose tissue
    • Khoo, J. C., A. A. Aquino, and D. Steinberg. 1974. The mechanism of activation of hormone-sensitive lipase in human adipose tissue. J. Clin. Invest. 53: 1124-1131.
    • (1974) J. Clin. Invest , vol.53 , pp. 1124-1131
    • Khoo, J.C.1    Aquino, A.A.2    Steinberg, D.3
  • 92
    • 0018826148 scopus 로고
    • Regulation of adipose tissue lipolysis: Effects of noradrenaline and insulin on phosphorylation of hormone-sensitive lipase and on lipolysis in intact rat adipocytes
    • Nilsson, N. O., P. Stralfors, G. Fredrikson, and P. Belfrage. 1980. Regulation of adipose tissue lipolysis: effects of noradrenaline and insulin on phosphorylation of hormone-sensitive lipase and on lipolysis in intact rat adipocytes. FEBS Lett. 111: 125-130.
    • (1980) FEBS Lett , vol.111 , pp. 125-130
    • Nilsson, N.O.1    Stralfors, P.2    Fredrikson, G.3    Belfrage, P.4
  • 93
    • 2642614548 scopus 로고    scopus 로고
    • Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
    • Anthonsen, M. W., L. Ronnstrand, C. Wernstedt, E. Degerman, and C. Holm. 1998. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J. Biol. Chem. 273: 215-221.
    • (1998) J. Biol. Chem , vol.273 , pp. 215-221
    • Anthonsen, M.W.1    Ronnstrand, L.2    Wernstedt, C.3    Degerman, E.4    Holm, C.5
  • 94
    • 0033961989 scopus 로고    scopus 로고
    • The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets
    • Brasaemle, D. L., D. M. Levin, D. C. Adler-Wailes, and C. Londos. 2000. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets. Biochim. Biophys. Acta. 1483: 251-262.
    • (2000) Biochim. Biophys. Acta , vol.1483 , pp. 251-262
    • Brasaemle, D.L.1    Levin, D.M.2    Adler-Wailes, D.C.3    Londos, C.4
  • 95
    • 0034681341 scopus 로고    scopus 로고
    • Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
    • Clifford, G. M., C. Londos, F. B. Kraemer, R. G. Vernon, and S. J. Yeaman. 2000. Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J. Biol. Chem. 275: 5011-5015.
    • (2000) J. Biol. Chem , vol.275 , pp. 5011-5015
    • Clifford, G.M.1    Londos, C.2    Kraemer, F.B.3    Vernon, R.G.4    Yeaman, S.J.5
  • 96
    • 0026783771 scopus 로고
    • Mechanism of hormone-stimulated lipolysis in adipocytes: Translocation of hormone-sensitive lipase to the lipid storage droplet
    • Egan, J. J., A. S. Greenberg, M. K. Chang, S. A. Wek, M. C. Moos, Jr., and C. Londos. 1992. Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Proc. Natl. Acad. Sci. USA. 89: 8537-8541.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8537-8541
    • Egan, J.J.1    Greenberg, A.S.2    Chang, M.K.3    Wek, S.A.4    Moos Jr., M.C.5    Londos, C.6
  • 97
    • 0242290249 scopus 로고    scopus 로고
    • Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes
    • Su, C. L., C. Sztalryd, J. A. Contreras, C. Holm, A. R. Kimmel, and C. Londos. 2003. Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes. J. Biol. Chem. 278: 43615-43619.
    • (2003) J. Biol. Chem , vol.278 , pp. 43615-43619
    • Su, C.L.1    Sztalryd, C.2    Contreras, J.A.3    Holm, C.4    Kimmel, A.R.5    Londos, C.6
  • 101
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins, C. M., D. J. Mancuso, W. Yan, H. F. Sims, B. Gibson, and R. W. Gross. 2004. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J. Biol. Chem. 279: 48968-48975.
    • (2004) J. Biol. Chem , vol.279 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5    Gross, R.W.6
  • 102
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis
    • Villena, J. A., S. Roy, E. Sarkadi-Nagy, K. H. Kim, and H. S. Sul. 2004. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J. Biol. Chem. 279: 47066-47075.
    • (2004) J. Biol. Chem , vol.279 , pp. 47066-47075
    • Villena, J.A.1    Roy, S.2    Sarkadi-Nagy, E.3    Kim, K.H.4    Sul, H.S.5
  • 106
    • 33646144117 scopus 로고    scopus 로고
    • ATGL has a key role in lipid droplet/ adiposome degradation in mammalian cells
    • Smirnova, E., E. B. Goldberg, K. S. Makarova, L. Lin, W. J. Brown, and C. L. Jackson. 2006. ATGL has a key role in lipid droplet/ adiposome degradation in mammalian cells. EMBO Rep. 7: 106-113.
    • (2006) EMBO Rep , vol.7 , pp. 106-113
    • Smirnova, E.1    Goldberg, E.B.2    Makarova, K.S.3    Lin, L.4    Brown, W.J.5    Jackson, C.L.6
  • 107
    • 33644764922 scopus 로고    scopus 로고
    • Adipose triglyceride lipase: Function, regulation by insulin, and comparison with adiponutrin
    • Kershaw, E. E., J. K. Hamm, L. A. Verhagen, O. Peroni, M. Katic, and J. S. Flier. 2006. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes. 55: 148-157.
    • (2006) Diabetes , vol.55 , pp. 148-157
    • Kershaw, E.E.1    Hamm, J.K.2    Verhagen, L.A.3    Peroni, O.4    Katic, M.5    Flier, J.S.6
  • 110
    • 33744937550 scopus 로고    scopus 로고
    • Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity
    • Mairal, A., D. Langin, P. Arner, and J. Hoffstedt. 2006. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia. 49: 1629-1636.
    • (2006) Diabetologia , vol.49 , pp. 1629-1636
    • Mairal, A.1    Langin, D.2    Arner, P.3    Hoffstedt, J.4
  • 112
    • 20544442848 scopus 로고    scopus 로고
    • Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase
    • Gao, J., and M. Simon. 2005. Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase. J. Invest. Dermatol. 124: 1259-1266.
    • (2005) J. Invest. Dermatol , vol.124 , pp. 1259-1266
    • Gao, J.1    Simon, M.2
  • 113
    • 34447094951 scopus 로고    scopus 로고
    • A comparative study of human GS2, its paralogues, and its rat orthologue
    • Gao, J. G., and M. Simon. 2007. A comparative study of human GS2, its paralogues, and its rat orthologue. Biochem. Biophys. Res. Commun. 360: 501-506.
    • (2007) Biochem. Biophys. Res. Commun , vol.360 , pp. 501-506
    • Gao, J.G.1    Simon, M.2
  • 114
    • 0034623950 scopus 로고    scopus 로고
    • Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
    • Brasaemle, D. L., B. Rubin, I. A. Harten, J. Gruia-Gray, A. R. Kimmel, and C. Londos. 2000. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 275: 38486-38493.
    • (2000) J. Biol. Chem , vol.275 , pp. 38486-38493
    • Brasaemle, D.L.1    Rubin, B.2    Harten, I.A.3    Gruia-Gray, J.4    Kimmel, A.R.5    Londos, C.6
  • 116
  • 117
    • 0037424252 scopus 로고    scopus 로고
    • Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols
    • Tansey, J. T., A. M. Huml, R. Vogt, K. E. Davis, J. M. Jones, K. A. Fraser, D. L. Brasaemle, A. R. Kimmel, and C. Londos. 2003. Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J. Biol. Chem. 278: 8401-8406.
    • (2003) J. Biol. Chem , vol.278 , pp. 8401-8406
    • Tansey, J.T.1    Huml, A.M.2    Vogt, R.3    Davis, K.E.4    Jones, J.M.5    Fraser, K.A.6    Brasaemle, D.L.7    Kimmel, A.R.8    Londos, C.9
  • 118
    • 0033546310 scopus 로고    scopus 로고
    • Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake
    • Gao, J., and G. Serrero. 1999. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J. Biol. Chem. 274: 16825-16830.
    • (1999) J. Biol. Chem , vol.274 , pp. 16825-16830
    • Gao, J.1    Serrero, G.2
  • 121
    • 33746176096 scopus 로고    scopus 로고
    • Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation
    • Larigauderie, G., C. Cuaz-Perolin, A. B. Younes, C. Furman, C. Lasselin, C. Copin, M. Jaye, J. C. Fruchart, and M. Rouis. 2006. Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation. FEBS J. 273: 3498-3510.
    • (2006) FEBS J , vol.273 , pp. 3498-3510
    • Larigauderie, G.1    Cuaz-Perolin, C.2    Younes, A.B.3    Furman, C.4    Lasselin, C.5    Copin, C.6    Jaye, M.7    Fruchart, J.C.8    Rouis, M.9
  • 122
    • 33745942915 scopus 로고    scopus 로고
    • Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins
    • Magnusson, B., L. Asp, P. Bostrom, M. Ruiz, P. Stillemark-Billton, D. Linden, J. Boren, and S. O. Olofsson. 2006. Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins. Arterioscler. Thromb. Vasc. Biol. 26: 1566-1571.
    • (2006) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 1566-1571
    • Magnusson, B.1    Asp, L.2    Bostrom, P.3    Ruiz, M.4    Stillemark-Billton, P.5    Linden, D.6    Boren, J.7    Olofsson, S.O.8
  • 123
    • 33748871923 scopus 로고    scopus 로고
    • Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis
    • Langin, D., and P. Arner. 2006. Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis. Trends Endocrinol. Metab. 17: 314-320.
    • (2006) Trends Endocrinol. Metab , vol.17 , pp. 314-320
    • Langin, D.1    Arner, P.2
  • 124
    • 0032230261 scopus 로고    scopus 로고
    • The short- and longterm effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes
    • Rosenbaum, S. E., and A. S. Greenberg. 1998. The short- and longterm effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. Mol. Endocrinol. 12: 1150-1160.
    • (1998) Mol. Endocrinol , vol.12 , pp. 1150-1160
    • Rosenbaum, S.E.1    Greenberg, A.S.2
  • 125
    • 0032544690 scopus 로고    scopus 로고
    • Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes
    • Souza, S. C., L. M. de Vargas, M. T. Yamamoto, P. Lien, M. D. Franciosa, L. G. Moss, and A. S. Greenberg. 1998. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 273: 24665-24669.
    • (1998) J. Biol. Chem , vol.273 , pp. 24665-24669
    • Souza, S.C.1    de Vargas, L.M.2    Yamamoto, M.T.3    Lien, P.4    Franciosa, M.D.5    Moss, L.G.6    Greenberg, A.S.7
  • 126
    • 0031948947 scopus 로고    scopus 로고
    • BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: A potential new insulin-sensitizing mechanism for thiazolidinediones
    • Souza, S. C., M. T. Yamamoto, M. D. Franciosa, P. Lien, and A. S. Greenberg. 1998. BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones. Diabetes. 47: 691-695.
    • (1998) Diabetes , vol.47 , pp. 691-695
    • Souza, S.C.1    Yamamoto, M.T.2    Franciosa, M.D.3    Lien, P.4    Greenberg, A.S.5
  • 127
    • 0037477829 scopus 로고    scopus 로고
    • Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
    • Sztalryd, C., G. Xu, H. Dorward, J. T. Tansey, J. A. Contreras, A. R. Kimmel, and C. Londos. 2003. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 161: 1093-1103.
    • (2003) J. Cell Biol , vol.161 , pp. 1093-1103
    • Sztalryd, C.1    Xu, G.2    Dorward, H.3    Tansey, J.T.4    Contreras, J.A.5    Kimmel, A.R.6    Londos, C.7
  • 129
    • 0025131389 scopus 로고
    • Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation
    • Egan, J. J., A. S. Greenberg, M. K. Chang, and C. Londos. 1990. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. J. Biol. Chem. 265: 18769-18775.
    • (1990) J. Biol. Chem , vol.265 , pp. 18769-18775
    • Egan, J.J.1    Greenberg, A.S.2    Chang, M.K.3    Londos, C.4
  • 131
    • 33847714769 scopus 로고    scopus 로고
    • Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes
    • Miyoshi, H., J. W. Perfield, S. C. Souza, W. J. Shen, H. H. Zhang, Z. S. Stancheva, F. B. Kraemer, M. S. Obin, and A. S. Greenberg. 2007. Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. J. Biol. Chem. 282: 996-1002.
    • (2007) J. Biol. Chem , vol.282 , pp. 996-1002
    • Miyoshi, H.1    Perfield, J.W.2    Souza, S.C.3    Shen, W.J.4    Zhang, H.H.5    Stancheva, Z.S.6    Kraemer, F.B.7    Obin, M.S.8    Greenberg, A.S.9
  • 132
    • 0030903768 scopus 로고    scopus 로고
    • Post-translational regulation of perilipin expression. Stabilization by stored intracellular neutral lipids
    • Brasaemle, D. L., T. Barber, A. R. Kimmel, and C. Londos. 1997. Post-translational regulation of perilipin expression. Stabilization by stored intracellular neutral lipids. J. Biol. Chem. 272: 9378-9387.
    • (1997) J. Biol. Chem , vol.272 , pp. 9378-9387
    • Brasaemle, D.L.1    Barber, T.2    Kimmel, A.R.3    Londos, C.4
  • 133
    • 33646017106 scopus 로고    scopus 로고
    • Degradation of perilipin is mediated through ubiquitination-proteasome pathway
    • Xu, G., C. Sztalryd, and C. Londos. 2006. Degradation of perilipin is mediated through ubiquitination-proteasome pathway. Biochim. Biophys. Acta. 1761: 83-90.
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 83-90
    • Xu, G.1    Sztalryd, C.2    Londos, C.3
  • 135
    • 3142738035 scopus 로고    scopus 로고
    • CGI-58 interacts with perilipin and is localized to lipid droplets: Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome
    • Yamaguchi, T., N. Omatsu, S. Matsushita, and T. Osumi. 2004. CGI-58 interacts with perilipin and is localized to lipid droplets: possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J. Biol. Chem. 279: 30490-30497.
    • (2004) J. Biol. Chem , vol.279 , pp. 30490-30497
    • Yamaguchi, T.1    Omatsu, N.2    Matsushita, S.3    Osumi, T.4
  • 137
    • 0028834525 scopus 로고
    • The turnover of cytoplasmic triacylglycerols in human fibroblasts involves two separate acyl chain length-dependent degradation pathways
    • Hilaire, N., R. Salvayre, J. C. Thiers, M. J. Bonnafe, and A. Negre-Salvayre. 1995. The turnover of cytoplasmic triacylglycerols in human fibroblasts involves two separate acyl chain length-dependent degradation pathways. J. Biol. Chem. 270: 27027-27034.
    • (1995) J. Biol. Chem , vol.270 , pp. 27027-27034
    • Hilaire, N.1    Salvayre, R.2    Thiers, J.C.3    Bonnafe, M.J.4    Negre-Salvayre, A.5
  • 138
    • 8944256087 scopus 로고    scopus 로고
    • Acylglycerol recycling from triacylglycerol to phospholipid, not lipase activity, is defective in neutral lipid storage disease fibroblasts
    • Igal, R. A., and R. A. Coleman. 1996. Acylglycerol recycling from triacylglycerol to phospholipid, not lipase activity, is defective in neutral lipid storage disease fibroblasts. J. Biol. Chem. 271: 16644-16651.
    • (1996) J. Biol. Chem , vol.271 , pp. 16644-16651
    • Igal, R.A.1    Coleman, R.A.2
  • 139
    • 0031883290 scopus 로고    scopus 로고
    • Neutral lipid storage disease: A genetic disorder with abnormalities in the regulation of phospholipid metabolism
    • Igal, R. A., and R. A. Coleman. 1998. Neutral lipid storage disease: a genetic disorder with abnormalities in the regulation of phospholipid metabolism. J. Lipid Res. 39: 31-43.
    • (1998) J. Lipid Res , vol.39 , pp. 31-43
    • Igal, R.A.1    Coleman, R.A.2
  • 144
    • 20744447492 scopus 로고    scopus 로고
    • Activation of the lipid droplet controls the rate of lipolysis of triglycerides in the insect fat body
    • Patel, R. T., J. L. Soulages, B. Hariharasundaram, and E. L. Arrese. 2005. Activation of the lipid droplet controls the rate of lipolysis of triglycerides in the insect fat body. J. Biol. Chem. 280: 22624-22631.
    • (2005) J. Biol. Chem , vol.280 , pp. 22624-22631
    • Patel, R.T.1    Soulages, J.L.2    Hariharasundaram, B.3    Arrese, E.L.4
  • 145
    • 0141672132 scopus 로고    scopus 로고
    • Drosophila perilipin/ADRP homologue Lsd2 regulates lipid metabolism
    • Teixeira, L., C. Rabouille, P. Rorth, A. Ephrussi, and N. F. Vanzo. 2003. Drosophila perilipin/ADRP homologue Lsd2 regulates lipid metabolism. Mech. Dev. 120: 1071-1081.
    • (2003) Mech. Dev , vol.120 , pp. 1071-1081
    • Teixeira, L.1    Rabouille, C.2    Rorth, P.3    Ephrussi, A.4    Vanzo, N.F.5
  • 148
    • 14844333134 scopus 로고    scopus 로고
    • Organelle-specific control of intracellular transport: Distinctly targeted isoforms of the regulator Klar
    • Guo, Y., S. Jangi, and M. A. Welte. 2005. Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar. Mol. Biol. Cell. 16: 1406-1416.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1406-1416
    • Guo, Y.1    Jangi, S.2    Welte, M.A.3


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