Mechanism of visceral fat reduction in Tsumura Suzuki obese, diabetes (TSOD) mice orally administered β-cryptoxanthin from Satsuma mandarin oranges (Citrus unshiu Marc)

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 23, 2011, Pages 12342-12351

  Takayanagi, Katsuhiko ^a   Morimoto, Sho Ichi ^a   Shirakura, Yoshiyuki ^a   Mukai, Katsuyuki ^a   Sugiyama, Toshie ^b   Tokuji, Yoshihiko ^c   Ohnishi, Masao ^c  

^a UNITIKA LTD   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

cryptoxanthin; adipocyte; Satsuma mandarin (Citrus unshiu Marc); TSOD

Indexed keywords

ADIPOCYTE; ADIPOCYTE HYPERTROPHY; ADIPOCYTES; ADIPOSE TISSUE; BODY WEIGHT; CYTOKINE SECRETIONS; DISEASE PREVENTION; GENE EXPRESSION ANALYSIS; SATSUMA MANDARIN; SERUM LIPID; TSOD; VISCERAL FAT;

ANTHROPOMETRY; CELL PROLIFERATION; GENE EXPRESSION; MAMMALS; MOLECULAR WEIGHT; PATHOLOGY; TISSUE;

PLANTS (BOTANY);

CRYPTOXANTHIN; XANTHOPHYLL;

ANIMAL; ARTICLE; CHEMISTRY; CITRUS; DIABETES MELLITUS; DRUG EFFECT; FRUIT; GENE EXPRESSION PROFILING; INTRAABDOMINAL FAT; MALE; MOUSE; OBESITY; ORGAN SIZE; PATHOLOGY;

ANIMALS; CITRUS; DIABETES MELLITUS; FRUIT; GENE EXPRESSION PROFILING; INTRA-ABDOMINAL FAT; MALE; MICE; OBESITY; ORGAN SIZE; XANTHOPHYLLS;

EID: 83055196925     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf202821u     Document Type: Article

References (39)

1. Smith, T. A. Carotenoids and cancer: prevention and potential therapy Br. J. Biomed. Sci. 1998, 55, 268-275
2. Young, A. J.; Lowe, G. M. Antioxidant and prooxidant properties of carotenoids Arch. Biochem. Biophys. 2001, 385, 20-27
3. Mangels, A. R.; Holden, J. M.; Beecher, G. R.; Forman, M. R.; Lanza, E. Carotenoid content of fruits and vegetables: an evaluation of analytic data J. Am. Diet. Assoc. 1993, 93, 284-296
4. Sugiura, M.; Kato, M.; Matsumoto, H.; Nagao, A.; Yano, M. Serum concentration of β-cryptoxanthin in Japan reflects the frequency of Satsuma mandarin (Citrus unshiu Marc.) consumption J. Health Sci. 2002, 48, 350-353
5. Sugiura, M.; Matsumoto, H.; Kato, M.; Ikoma, Y.; Yano, M.; Nagao, A. Multiple linear regression analysis of the seasonal changes in the serum concentration of β-cryptoxanthin J. Nutr. Sci. Vitaminol. 2004, 50, 196-202
6. Bramlev, P. V. Is lycopene beneficial to human health? Phytochemistry 2000, 54, 233-236
7. Cooney, R. V.; Bertram, J. S.; Hankin, J. H.; Kolonel, L. N.; Miyake, A.; Billings, K.; Bourne, W. Relationship between dietary, serum, and tissue levels of carotenoids Cancer Lett. 1991, 61, 81-87
8. Glise, D.; Riondel, J.; Favier, A. Comparative distribution of β-carotene and lycopene after intraperitoneal administration in mice In Vivo 1998, 12, 447-454
9. Kaplan, L. A.; Lau, J. M.; Stein, E. A. Carotenoid composition, concentration, and relationships in various human organs Clin. Physiol. Biochem. 1990, 8, 1-10
10. Nair, P. P.; Lohani, A.; Norkus, E. P.; Feagins, H.; Bhagavan, H. N. Uptake and distribution of carotenoids, retinal, and tocopherols in human colonic epithelial cells in vivo Cancer Epidemiol. Biomarkers Prev. 1996, 5, 913-916
11. Sugiura, M.; Nakamura, M.; Ikoma, Y.; Yano, M.; Ogawa, K.; Matsumoto, H.; Kato, M.; Ohshima, M.; Nagao, A. High serum carotenoids are inversely associated with serum γ-glutamyltransferase in alcohol drinkers within normal liver function J. Epidemiol. 2005, 15, 180-186
12. Sugiura, M.; Nakamura, M.; Ikoma, Y.; Yano, M.; Ogawa, K.; Matsumoto, H.; Kato, M.; Ohshima, M.; Nagao, A. Serum carotenoid concentrations are inversely associated with serum aminotransferases in hyperglycemic subjects Diabetes Res. Clin. Practice 2006, 71, 82-91
13. Nishino, H.; Tokuda, H.; Murakoshi, M.; Satomi, Y.; Masuda, M.; Onozuka, M.; Yamaguchi, S.; Takayasu, J.; Tsuruta, J.; Okuda, M.; Khachik, F.; Narisawa, T.; Takastuka, N.; Yano, M. Cancer prevention by natural carotenoids Biofactors 2000, 13, 89-94
14. Rauscher, R.; Edenharfer, R.; Platt, K. L. In vitro antimutagenic and in vivo anticlasogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids Mutat. Res. 1998, 413, 129-142
15. Tanaka, T.; Kohno, H.; Murakami, M.; Shimada, R.; Kagami, S.; Sumida, T.; Azuma., Y.; Ogawa, H. Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats my mandarin juices rich in β-cryptoxanthin and hesperidin Int. J. Cancer 2000, 88, 146-150
16. Uchiyama, S.; Yamaguchi, M. Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats Int. J. Mol. Med. 2006, 17, 15-20
17. Sugiura, M.; Nakamura, M.; Ogawa, K.; Ikoma, Y.; Ando, F.; Yano, M. Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids Osteoporos. Int. 2008, 19, 211-219
18. Sugiura, M.; Nakamura, M.; Ogawa, K.; Ikoma, Y.; Ando, F.; Shimokata, H.; Yano, M. Dietary patterns of antioxidant vitamin and carotenoid intake associated with bone mineral density: findings from post-menopausal Japanese female subjects Osteoporos. Int. 2011, 22, 143-152
19. Sugiura, M.; Nakamura, M.; Ikoma, Y.; Yano, M.; Ogawa, K.; Matsumoto, H.; Kato, M.; Ohshima, M.; Nagao, A. The homeostasis model assessment-insulin resistance index is inversely associated with serum carotenoids in non-diabetic subjects J. Epidemiol. 2006, 16, 71-78
20. Sugiura, M.; Ogawa, K.; Yano, M. Effect of chronic administration of fruit extract (Citrus unshiu Marc.) on glucose tolerance in GK rats, a model of type 2 diabetes Biosci., Biotechnol., Biochem. 2006, 70, 293-295
21. Sugiura, M.; Matsumoto, H.; Kato, M.; Ikoma, Y.; Yano, M.; Nagao, A. Seasonal changes in the relationship between serum concentration of β-cryptoxanthin and serum lipid levels J. Nutr. Sci. Vitaminol. (Tokyo) 2004, 50, 410-415
22. Tsuchida, T.; Minagawa, K; Mukai, K.; Mizuno, Y.; Mashiko, K.; Minagawa, K. The comparative study of β-cryptoxanthin derived from Satsuma mandarin for fat of human body Jpn. Pharmacol. Ther. 2008, 36, 247-253
23. Hirayama, I.; Yi, Z.; Izumi, S.; Arai, I.; Suzuki, W.; Nagamachi, Y.; Kuwano, H.; Takeuchi, T.; Izumi, T. Genetic analysis of obese diabetes in the TSOD mouse Diabetes 1999, 48, 1183-1191
24. Suzuki, W.; Iizuka, S.; Tabuchi, M.; Funo, S.; Yanagisawa, T.; Kimura, M.; Sato, T.; Endo, T.; Kawamura, H. A new mouse model of spontaneous diabetes derived from ddY strain Exp. Anim. 1999, 48, 181-189
25. Huang, D. W.; Sherman, B. T.; Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat. Protoc. 2009, 4, 44-57
26. Kanehisa, M.; Goto, S.; Furumichi, M.; Tanabe, M.; Hirakawa, M. KEGG for representation and analysis of molecular networks involving diseases and drugs Nucleic Acids Res. 2010, 38, D355-D360
27. Hertzel, A. V.; Smith, L. A.; Berg, A. H.; Cline, G. W.; Shulman, G. I.; Scherer, P. E.; Bernlohr, D. A. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice Am. J. Physiol. Endocrinol. Metab. 2006, 290, 814-823
28. Choi, B. H.; Kim, Y. H.; Ahn, I. S.; Ha, J. H.; Byun, J. M.; Do, M. S. The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling Nutr. Res. Pract. 2009, 3, 84-88
29. Ajuwon, K. M.; Spurlock, M. E. Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288, 1220-1225
30. Rabe, K.; Lehrke, M.; Parhofer, K. G.; Broedl, U. C. Adipokines and insulin resistance Mol. Med. 2008, 14, 741-751
31. Tang, Q. Q.; Otto, T. C.; Lane, M. D. Mitotic clonal expansion: a synchronous process required for adipogenesis Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 44-49
32. Okamoto, Y.; Folco, E. J.; Minami, M.; Wara, A. K.; Feinberg, M. W.; Sukhova, G. K.; Colvin, R. A.; Kihara, S.; Funahashi, T.; Luster, A. D.; Libby, P. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis Circ. Res. 2008, 102, 218-225
33. Issemann, I.; Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 1990, 347, 645-650
34. Chawla, A.; Schwarz, E. J.; Dimaculangan, D. D.; Lazar, M. A. Peroxisome proliferator-activated receptor (PPAR) γ: adipose-predominant expression and induction early in adipocyte differentiation Endocrinology 1994, 135, 798-800
35. Berger, J.; Wagner, J. A. Physiological and therapeutic roles of peroxisome proliferator-activated receptors Diabetes Technol. Ther. 2002, 4, 163-174
36. Gosset, P.; Charbonnier, A. S.; Delerive, P.; Fontaine, J.; Staels, B.; Pestel, J.; Tonnel, A. B.; Trottein, F. Peroxisome proliferator-activated receptor γ activators affect the maturation of human monocyte-derived dendritic cells Eur. J. Immunol. 2001, 31, 2857-2865
37. Shirakura, Y.; Takayanagi, K.; Mukai, K.; Tanabe, H.; Inoue, M. β-Cryptoxanthin suppresses the adipogenesis of 3T3-L1 cells via RAR activation. J. Nut. Sci. Vitaminol. 2011, in press.
38. Mourier, A.; Gautier, J. F.; De Kerviler, E.; Bigard, A. X.; Villette, J. M.; Garnier, J. P.; Duvallet, A.; Guezennec, C. Y.; Cathelineau, G. Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM: effects of branched-chain amino acid supplements Diabetes Care 1997, 20, 385-391
39. Yoon, M. The role of PPARα in lipid metabolism and obesity: focusing on the effect of estrogen on PPARα actions Pharmacol. Res. 2009, 60, 151-159